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Flashcards in Medications Deck (18):
1

What is the mechanism of unfractionated heparin

AT-3 activator
Inhibits thrombin (2a), 3, 10a

2

Mechanism of fondaparinux (Atrixtra)

Indirect 10a inhibitor (via AT-3)

3

Direct 10a inhibitors

Rivaroxaban (Xarelto)
Apixaban (Eliquis)
Edoxaban (Savaysa)

4

Mechanism of dabigatraban (Pradaxa), Argatroban

Direct 2a (thrombin) inhibitor

5

Mechanism of TXA

Lysine synthetic
Inhibits activation of plasminogen -> plasmin
Prevents fibrinolysis (breakdown of Factor 1a - fibrin)

6

N-containing bisphosphonate mechanism

GTPase formation via farnesyl pyrophosphate synthase

7

Denosumab mechanism

Binds + inhibits RANKL
Inhibits osteoclast function

8

Mechanism of LMW heparin

Inhibits factor Xa

9

What abx inhibits 30S subunit

Tetracycline, aminoglycoside

10

Cephalosporin MOA

Prevent peptidoglycan cross-linkage in cell wall synthesis

11

Glycopeptide MOA (Vancomycin)

Prevent addition of cell wall subunits

12

Rifampin MOA

RNA polymerase

13

What do corticosteroids do

Inhibit phospoholipase A2
Prevent arachidonic acid formation

14

Benefits of LMWH vs unfractionated heparin

Longer half life (3-18 hrs vs 1)
Selectively targets Xa
Lower HIT risk
Similar risk of bleeding to Coumadin

15

What does glucosamine do

Acts as substrate for proteoglycan synthesis

16

Mechanism of Botox

Competitive inhibitor of PRE-SYNAPTIC ACh receptors

17

Contraindications to Teriparatide

Paget's
Previous mets

Risk of secondary osteosarcoma

18

Drugs that worsen osteoporosis

Anti-epileptics
Prednisone
PPI
Heparin