bone mineral drugs

Question 1

abnormalities in bone mineralization can lead to

Answer 1

tetany, muscle weakness,osteoporosis, infantile osteoporosis (loss of hameopoetic cacpacity), coma

Question 2

hormonal regulators of bone mineral homeostasis

Answer 2

pth, calcitonnin, estrogen, vit d, glucocorticoid

Question 3

non hormonal regulators of bone mineral homeostasis

Answer 3

bisphosphanates, fluoride, calcimimetics

Question 4

pth moa

Answer 4

it binds to osetoblasts causing the release of rank lingand which binds to rank ligand receptor on osteoclasts. this causes thier activation—release of enzymes—increase in bone resorption
2. increases ca and mg reabsorption in kidneys
3. stimulates 1-alpha hydroxylase enzyme that proces 1,25 dihydrocholecalciferol from 25 cholecalciferol.
4. causes secretion of po4

Question 5

pth does bone resorption at what levels

Answer 5

high conce present continously

Question 6

at low and intermittent levels, pth’s fucntion?

Answer 6

increases bone formation through gf like igf1

Question 7

synthetic recombitant pth thats used in osetoporosis?

Answer 7

1,34 teriparatide

Question 8

indications for teriparatide

Answer 8

osetoporosis, verebral and non-vertrebral fractures

Question 9

se of teriparatide

Answer 9

high cost, need for daily sc injections, dizziness, leg cramps

Question 10

contraindications for teriparatide

Answer 10

pagets disease, hypercalcemia

Question 11

diag use of teriparatide

Answer 11

inj of teriparatide increases blood calcium levels. if not, then it is pseudohypoparathyroidism.

Question 12

m

Answer 12

l

Question 13

calcitonnin moa

Answer 13

inhibits the receptors on the osteoclastic cells thus osteoblastic activity increases in comparison

Question 14

calcitonnin synthetic form

Answer 14

salmon calcitonnin

Question 15

calcitonnin uses

Answer 15

pagets disease
osteoporosis
Hyperparathyroidism, hypervitaminosis D,
osteolytic bony metastasis and hypercalcaemia of malignancy;

Question 16

se of calcitonnin

Answer 16

Nausea, flushing and tingling of fingers Bad taste, flu-like symptoms, allergic reactions and joint pain a

Question 17

calcitonnin route

Answer 17

im, sc, nasal spray

Question 18

calcitonnin effectiveness in post meanopausal women

Answer 18

bpns, hrt are more effective. this is only given when other drugs cannot be given
or when women are postmenopausal for 5 years with osteoporosis

Question 19

se of nasal spray use of calcitonnin

Answer 19

rhinitis,
epistaxis,
nasal ulceration and
headache are produced frequently