Bone Mineral Storage

Question 1

Bone is a store of …. and ….. for the body

Answer 1

Calcium & Phosphate

Question 2

Calcium is bound to bone by ….

Answer 2

OSTEONECTIN

Question 3

Calcitnonin
. produced by what
. what impact does it have on blood calcium levels - how

Answer 3

Calcitonin
. secreted by thyroid
. reduces blood calcium levels by inhibiting osteoclast activity

Question 4

What is the purpose of calcitrol

Answer 4

Calcitrol is used to release calcium from bone by inducing release of RANKL from osteoblasts which activates osteoclasts so bone is degraded

Question 5

State the function of osteonectin

Answer 5

Calcium is bound to bone by osteonectin

Question 6

Compare & contrast calcitonin & calcitrol

Answer 6

Calcitrol is used to release calcium from bone by inducing release of RANKL from osteoblasts which activates osteoclasts so bone is degraded

Calcitonin is secreted by the thyroid and reduces blood calcium levels inhibiting osteoclast activity

Question 7

Effect of parathryoid hormone on blood calcium levels? Why?

Answer 7

Parathyroid hormone stimulates osteoclasts so increases blood calcium levels