breast

Question 1

lobular strome lesions

Answer 1

arising biphasiccc

fibroadenoma
phyllodes tumor

Question 2

msot common benig tumor of breatd

Answer 2

fibroadenoma

Question 3

phyllodes tumor

Answer 3

leaf like
more older
more cellualr

Question 4

large duct and lactiinferous sinuss

Answer 4

duct ectasia
recurrent subareolar abscess–>abscessing mastitis
solitary ductal papilloma
pagets disease: maligint

Question 5

non neoplastic lesions

Answer 5

inflammatory lesions
-duct ectasia–>periductal mastitis(stapylococus form baby), abscess

reactive lesions: fat necrosis, granulomas aroung foreigb ody

dysplastic chnages: fibrocystic disease

Question 6

fibrocystic diseas of breast
-general clinical and wh

Answer 6

-palpabe
-irr mensturatuin+pain
-uknown
-fertile women: 25-50y
-heterogenous aperance

Question 7

micro of fibrocystic diases

Answer 7

non-prolif chnages
- cyst, dilation of fucts
-stromal fibrosis
-apocrine mtaplasia

prolif cgnages wihtout atypia
-hyperplasia without atypia
-adneosis

prolif w atypia
-atypical hyperplasia
-scelorsing adenosis

Question 8

adenosis

Answer 8

-^nr of small ducts
-galndular acini or intralobular strome
-PRESERVED cell layers=2=secretory and myoepi
-basically laobules enlarged and more glands than usual!!!!

maybe palpabe
PRESERVED architercture
ass w fibrosis
types: florid, sceloring, microglandular, tubular

Question 9

radical scar/complex sclerosinglesion

Answer 9

-satr like
-FIBROELASTOSIS and epi hyperplaisa
-pseudoinfiltartion

maybe palpable
<1cm=radical svar
>1cm=complex scleroisng
MYEEPI STILL PRESENT=BENING

Question 10

bening epi tumor

Answer 10

PAPILLOMA: MOST BENING TRULY EPI
ADENOMA: VERY RARE

Question 11

Maligntn epi tumor

Answer 11

1. non invasive
   -DCIS
   -LCIS
2. inavsive
   -DIC-most frequent
   -LIC
   -OTHERS

Question 12

evolution of breast carcinoma

Answer 12

normal–>hyperlasia

aytypical hyperplasia–>DCIS–>inasive cnacer

Question 13

bening epi prolif

Answer 13

adenosis, adenoma

Question 14

papilalry lesions

Answer 14

papilloma, papillary carcinoma, subtypes

Question 15

precursor lesions

Answer 15

DCIS
lobular neoplasia-LCIS, ALH

Question 16

invasive carcinoma

Answer 16

invasive carcinoma of no special type -NST:MOST FREQUENT TYPE
invasive lobular carcinoma-LIC…..

Question 17

ductal carcinoma

Answer 17

within ducts
-small medium sized
-^nr of CELL LAYERS IN DUCTS >3

classificaiton
1. usual-no atypia
2. columanr lesion\flat epi atypia
3. atypical

Question 18

atypical ducatl hyperplasia ADH

Answer 18

-neoplastic intraductal lesions
-<2-3mm
-mayeb multicentric, microcalcificaiton
-NO MASS
-her1, p53
-pre&post menopausel women, BOTH BREAST

Question 19

Lobular hyperplasia

Answer 19

-prolif of discohesive cells in lobualr(Acinar part of TDLU
-ONLY ATYPICAL
-mutlicentric
40-50y , incident
-NO MASS

Question 20

Non invasice BC - CIS

Answer 20

-duct/lobular units
-INASION OFTHORUGH BM–>STROMA

EX
DCIS: comedo, solid , cribrifomr, papi, micropappi
LCIS: multicentric

Question 21

DCIS/intraductal

Answer 21

-Preinvasive, intact BM
-non invasive prolif of cohesive cells
-mayeb palpable+discharge+necrois!!!!!!!!!
-recurrency

comedo: cental necrosis
cribriform: fenestartion/openign

Question 22

LCIS

Answer 22

-prolif of tumor cells within lobar part
-must fill or distend lobular unit
-not identifiable

Question 23

breast caricnoma

Answer 23

most cdoommon female malignt tymor
20-75 y

risk factors
1. sporadic form-unkown
2. familair
3. hereditary: BRCA1 AND BRCA2

Question 24

clinical BC

Answer 24

tecture chneg
dimpling
lymph discharge
bloody discharge
redness/rash
lump in armpit
nipple inversion
lump

UPPER LR QUADRANT MOSLTYY–>CENTRAL–>LOWER LAT–

Question 25

Rsik factor of BC

Answer 25

hormonal genetic abnormalitis of oncogene and tumor supresor gene -HER2, C-MYC, TP53 geo other: white, fibrocystic disease w atypical prolif, previous BC, nulliparity, early menstuaiton and late menopause, hormonal, tumor of oavry, obestiy,

Question 26

moleculr classificaiton of BC

Answer 26

1. CA with luminal diff of type 1-LUMINAL a - ER/PR+, her2-(low prolif) 2. LUMINAL B -er+, her2++++ 3. HER2++, Ca -ER-----, HER2+ 4. trople neg---- 4a. basaloid ca 4b. normal breast like

Question 27

pagets disease

Answer 27

-eczematoid chnages of nipple Pagets cells: large pale -underlying DCIS OR Invasive carcinoma

Question 28

inflammatory carcinoma

Answer 28

-high grade macro: enlarged, edematous, erythmetous breast, rapid growth, soft consistency, ornage plae skin micro: -angioinvasion to lymoatics agrrssiev and bad