Breast ca Flashcards Preview

Medical oncology > Breast ca > Flashcards

Flashcards in Breast ca Deck (8):
1

WLE + radiotx

Equivalent to mastectomy

2

Chemotherapy for breast ca

Anthracyclines /taxanes

3

Gonadotoxic

Cylophosphamide

4

Beware interaction between tamoxifen and CYP2D6

SSRI, SNRI

5

Traztuzumab is always given with chemotherapy

Idiosyncratic cardiotoxicity, but mostly reversible
No CNS penetration --> cerebral mets often sanctuary site

6

trastuzumab/emtansine

Antibody drug conjugate for targeted delivery to cell
Thrombocytopenia MAIN side effect

7

+ve axillary LN is the worst prognostic factor

followed by triple negative

8

BRCA are TSG (DNA repair gene)

AD with variable penetrance
Prostate and pancreatic cancer also have association