Breast & Endometrial Ca Flashcards Preview

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Flashcards in Breast & Endometrial Ca Deck (13)
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1

Anastrozole

Aromatase inhib (cyp19A1) nonsteroidal

Cataracts!

2

Exmestane

Aromatase inhib (cyp19A1) steroidal

IRREVERSIBLE inhibitor

3

Letrozole

Aromatase inhib (cyp19A1) nonsteroidal

Cataracts!

4

Raloxifene

SERM

Relax! no endometrial Ca.
(you still get stroke risk)

5

Tamoxifen

SERM - Endometrial Ca risk!
stroke risk

6

Toremifene

SERM (QT prolongation!)

7

Fulvestrant

SERD
perimenipausal symptoms
CatX! Retinal degradation! DVT/PE!

8

Goserelin

GnRH agonist
bone density loss
causes initial flare in disease (FSH/LH surge)

9

Pertuzumab

HER2/neu inhib (binds dimerization domain)

alopecia

BBW preg

10

Traztuzumab

HER2/neu inhib (binds extracellular domain)

weight GAIN, URTI, rash

BBW cardiomyopathy, infusion rxn, pregnancy, ARDS, hepatotoxicity

11

Lapatinib

TKI vs HER1/2

BBW: liver disease, QT prolongation

12

Everolimus

mTOR inhibitor
BBW: infection, secondary malignancy

13

all tripple negative brca

give phosphamide & something else