Urinary Incontinence or Retention Flashcards Preview

Repro Pharm CBD > Urinary Incontinence or Retention > Flashcards

Flashcards in Urinary Incontinence or Retention Deck (11)
Loading flashcards...
1

Darifenacin

M3 selective anticolinergic

2

Oxybutynin

nonselective muscarinic anticolinergic

3

Solifenacin

nonselective muscarinic anticolinergic

high oral bioavailability, 60 hr t1/2

4

Trospium

nonselective muscarinic anticolinergic

80% renal excretion
poor bioavailability

5

Mirabegron

beta3 specific agonist. relaxes bladder.

gigantic half life

6

Neostigmine

acetylcholinesterase inhibitor - poor bioavialability

inactivated by acetylcholinesterases

renally excreted

short T1/2 (<1 hr)

7

Location of M3 receptors

detrusor parasympathetics (ACh) (contracts)

8

Location of Beta3 receptors

detrusor sympathetics (NA, hypogastric nerve). contraction - voiding.

9

Location of Alpha1 receptors

Urethra (sympathetic)

10

location of nicotinic receptor & function

external urethral sphincter - volitional control M3/M2

11

Location of M2 receptor & opposed by?

bladder (&other places) opposed by beta receptor

M2 decreases contraction - retention