Breast / Gynae Flashcards by Manisha M

Q

PARP Inhibitor Indication

A

BRCA 1 and 2 mutations

How well did you know this?

1

Not at all

2

3

4

5

Perfectly

Q

Side effects of aromatase inhibitors (anastrozole)

A

MSK pain / stiffness
OP / fractures
CVD
Hyperchol

Hot flushes
sexual dysfunction

How well did you know this?

1

Not at all

2

3

4

5

Perfectly

Q

Side effects of SERMs (tamoxifen)

A

PE/VTE
Endometrial ca
Fatty liver
Eye problems - cataracts

Hot flushes
sexual dysfunction

How well did you know this?

1

Not at all

2

3

4

5

Perfectly

Q

PALB2 gene increases risk of ___ cancer

A

1) Breast
2) Ovarian
3) Pancreatic

How well did you know this?

1

Not at all

2

3

4

5

Perfectly

Q

CDK4/6 Inhibitor works in which part of the cell cycle

A

G1 to S

How well did you know this?

1

Not at all

2

3

4

5

Perfectly

Q

Which targeted therapy options increase efficacy of anti oesotrogen therapy (ER+ met breast ca)

A

mTOR inhibitors
CDK 4/6 inhibitors

How well did you know this?

1

Not at all

2

3

4

5

Perfectly