Lung / Skin / Brain Flashcards
(13 cards)
1
Q
Stage I or Stage II treatment NSCLC
A
- Surgical mx if medically fit
- Stereotactic radiotherapy if not medically fit
2
Q
Adjuvant therapy for stage II to IIIa NSCLC
A
- Platinum based CTx
- Immunotherapy
3
Q
Stage III non-resectable NSCLC
A
- Chemoradiotherapy
- Immunotherapy
4
Q
EGFR mutation targeted therapy
A
- Osimertinib - current standard of care 1st line
- Cetuximab
5
Q
ALK gene rearrangement targeted therapy
A
- Alectinib
6
Q
ROS-1 targeted therapy
A
- Entrectinib
7
Q
Limited SCLC Mx
A
- Cisplatin and etoposide 2x cycles
- RTx with further 2 cycles
- Prophylactic brain RTx
8
Q
Extensive SCLC Mx
A
- Atezozlimab (PDL-1)
- Cis/carboplatin with etoposide 4x cycles
- Brain RTx if brain mets
9
Q
Mesothelioma Mx
A
1st line - ipilimumab and nivolumab or CTx (cisplatin with pemtrexed)
10
Q
CTLA-4 Immunotherapy
A
Ipilimumab
11
Q
Metastatic melanoma (BRAF-Wildtype)
A
PD inhibitor
12
Q
Metastatic melanoma (BRAF-Mutant)
A
MEK inhibitor + BRAF inhibitor
13
Q
Microsatelliete instability
A
Carry better prognosis
More mucinous
Display more lymphocytic invasion
More often proximal
