Broad overview Flashcards
(23 cards)
what molecule breaks apart the hinge region of Igs
papain
what are the main neutralizing Igs
G and A
what are the main opsonizing Igs
G
what are the main polymeric Igs
A(2) and M(5)
what Igs mediate the ADCC system
G
What is the function of the ADCC system
identification and destruction of tumor cells and virally infected cells–IgG minds receptors on the surfaces of these cells and attracts NKCs which destroy the target cell via induced apoptosis
What composes the B cell receptor
The immunoglobin and Ig(alpha) and Ig(beta)
What do Ig(alpha) and (beta) do for B cells
they activate signaling molecules
where do VJ/V(D)J rearrangement occur
continuously in the bone marrow
on what level does VJ/V(D)J rearrangement occur, DNA, RNA, or protein?
RNA
What proteins are required for VJ/V(D)J recombination
Rag-1 and Rag-2
What does the AID protein mediate
CSR and SHM
on what level do CSR and SHM cause changes
genetic
what produced IL-1 and TNF and what are their function
dendritic cells which have been activated. They cause the endothelial cells in the immediate area to become sticky allowing circulating lymphocytes to extravassate to the site of infection
what is CRP and what is it’s significance
it is produced by dendritic cells and is a quantitative indicator of disease activity
what is the function of IFN alpha and beta
both are antiviral proteins
what does IL-6 do
makes you sick; increases your WBC count
what does IL-12 do
activates T cells and NKCs
what does IL-10 do
decreases the immune response
where is the MHC gene located
p arm of chromosome 6
what are the MHC I proteins
A, B, and C
What are the MHC II proteins
DP, DQ, and DR
where is beta-2-microglobulin found
on MHC Is
