Brugia malayi/ Timori Flashcards
(30 cards)
What is the common name for Brugia malayi?
Malayan filaria
What is the habitat of Brugia malayi adult worms and microfilariae in humans?
Adult worms: Lymph nodes, Lymphatic vessels; Microfilariae: Blood
What is the mode of transmission for Brugia malayi?
Skin penetration (via mosquito bites)
What is the infective stage of Brugia malayi?
L3 larvae (transmitted by mosquito bites)
What is the diagnostic stage of Brugia malayi?
Microfilariae
Name the biological vectors (intermediate hosts) for Brugia malayi.
Mosquitos (Mansonia, Anopheles, Aedes)
Similar to W. bancrofti only smaller in size.
Brugia malayi
Sheathed; 2 terminal nuclei at tip of tail, separate from the rest of body nuclei; Tail is tapered with a significant gap between the terminal & subterminal nuclei.
Brugia malayi microfilariae
What type of periodicity do Brugia malayi microfilariae exhibit?
Nocturnal periodicity
What is the term for the disease caused by Brugia malayi?
Malayan filariasis
How does the course of brugian filariasis typically differ from Wuchereria bancrofti infection?
The course of brugian filariasis is usually restricted to the legs; no chyluria & involvement of male genitalia.
What are the common laboratory diagnostic methods for Brugia malayi?
Detection of microfilariae; PCR; DNA probes.
What is the drug of choice for treating Brugia malayi infection?
Diethylcarbamazine (DEC)
What is a specific prophylactic measure mentioned for controlling Mansonia vectors in India?
Removal of aquatic plants (water lettuce) since larval Mansonia vectors obtain oxygen from the roots of these plants.
In which geographical regions is Brugia malayi commonly found?
India, Far East, & Southeast Asia.
What is the common name for Brugia timori?
Timori filaria
What is the habitat of Brugia timori in humans?
Lymphatics of man
What is the mode of transmission for Brugia timori?
Skin penetration (via mosquito bites)
What is the infective stage of Brugia timori?
L3 larvae (transmitted by mosquito bites)
What is the diagnostic stage of Brugia timori?
Microfilariae
What is the definitive host for Brugia timori?
Man
What is the intermediate host for Brugia timori?
Anopheles barbirostris
What are the general characteristics of Brugia timori adult worms compared to W. bancrofti?
Similar to W. bancrofti only smaller in size.
Describe the key morphological features of Brugia timori microfilariae, especially the cephalic space and tail nuclei.
Longer cephalic space; sheath that does not stain with Giemsa; large number of single-file nuclei towards the tail; tail is tapered with a significant gap between the terminal & subterminal nuclei.
