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Flashcards in Bugs and drugs Deck (33):
1

Gram + cocci

Staphylococcus
Streptococcus
Enterococcus

2

Gram - cocci

Neisseria gonorrhea

3

Gram - bacilli

E. coli
Pseudomonas

4

Gram + anaerobic bacilli

Clostridia

5

Gram - anaerobic bacilli

Bacteroides

6

Atypical

Chlamydia

Mycoplasma

7

Which cell wall synthesis inhibitors are absorbed PO?

PCN -V
Oxacillin
Dicloxacillin
Amoxicillin
Ampicillin
___________________
All cephalosporins except
- Cefazolin (1st)
- Cefoxitin (2nd)
- Ceftriaxone (3rd)
____________________
Vanc when treating C.Diff

8

Which cell wall synthesis inhibitors are administered IV?

PCN-G
Methicillin
Ticarcillin
Piperacillin (PIP-TAZO)
___________________
3 of the Cephalosporins:
- Cefazolin (1st)
- Cefoxitin (2nd)
- Ceftriaxone (3rd)
___________________
Carbapenems
_____________
Vanc except for C. Diff

Pa-pa-sa-sa-va!

9

Which protein synthesis inhibitors are absorbed PO?

All the protein synthesis inhibitors except:
Streptogamins
AGs

10

Which protein synthesis inhibitors are administered IV?

Streptogamins
AGs

11

Which inhibitor of DNA fxn are absorbed PO?

FQ
- Cip, Levo, Mox

Nitrofurantoin
Metronidazole

12

Sulfonamides are absorbed PO or administered IV?

PO

13

Drugs that distribute to CSF

PCN (if tissue is inflammed)
Ceftriaxone (3rd gen ceph)
Carbapenams
___________
Chloramphenicol
Metronidazole
Sulfonamides

14

Drugs that distribute to urine

AG
FQ
- (Cip, Levo)
NF

15

Drugs that distribute to bone

Clindamycin
Metrinidazole

16

Drugs that distribute to lungs

Macrolides (ACE)
FQ
- Levo, Mox

17

Drugs that distribute to bone (Bad)

TCN

18

Drugs that distribute to teeth (Bad)

TCN

19

Drugs that distribute to kidney (Bad)

AGs

20

Drugs that contribute to 8th nerve damage (Bad)

AGs

21

Drugs that distribute to fetus (Bad)

Cephalosporins
Macrolides (ACE)
TCN
______________
Sulfonamides

22

Drugs that are eliminated Non-renally can cause what 3 negative side effects?

1. drug-drug interactions,
2. genetic polymorphisms in metabolizing enzymes, ]
3. potential for hepatotoxicity:

23

List Drugs that are eliminated Non-renally

D - oxycyclin
Q - uinolones (mox)
C - lindamycin
R - rifampin
I - soniazid
M - etronidazole
E - rythromycin like drugs (ery and Azi are biliary excretion)
S - ulfonamides

24

Which DQCRIME drugs are inhibitors of P450?

Quinolones
Erythromycin

25

Which DQCRIME drugs are inducers of P450?

Rifampin

26

Metronidazole and Erythromycin like drugs are at risk for DDI, but via different mechanisms. Explain

Metronidazole: drug-drug interaction with alcohol due to inhibition of aldehyde metabolism (Antabuse reaction)

Erythromycin-like: drug-drug interactions due to inhibition of P450 (Clar-Ery not Azi)

27

Renally excreted drugs

PCN
Cephalosporins
Carbapenams
Vanc
_________
AGs
FQ (Cip, levo)

28

-Cidal drugs

All the CW synth inhibitors
___________________
Oxazolidinones for strep
Streptogamin (whn used synergistically w/ quinupristen)
AGs
____________
All inhibitors of DNA fxn

29

- Static drugs

Macrolides (ACE)
Clindamycin
Chloremphenicol
Oxazolidinones
TCN

- Basically All protein synthesis inhibitors except:
Oxazolidinones for strep
Streptogamin (whn used synergistically w/ quinupristen)
AGs

30

Which Protein synthesis inhibitors inhibit the 30s subunit?

TCN
AGs

31

Narrow spectrum drugs list

PCN
VANC
AGs

32

Extended spectrum drug list

Extended spectrum PCN
Anti-pseudomonal (PIP/Tazo)
Cephalosporin
Carbapenam (wide spectrum)
_____________
Macrolides
FQ

33

Broad spectrum drug list

Chloramphenicol
TCN
Sulfonamides