Bugs and drugs

Question 1

Gram + cocci

Answer 1

Staphylococcus
Streptococcus
Enterococcus

Question 2

Gram - cocci

Answer 2

Neisseria gonorrhea

Question 3

Gram - bacilli

Answer 3

E. coli

Pseudomonas

Question 4

Gram + anaerobic bacilli

Answer 4

Clostridia

Question 5

Gram - anaerobic bacilli

Answer 5

Bacteroides

Question 6

Atypical

Answer 6

Chlamydia

Mycoplasma

Question 7

Which cell wall synthesis inhibitors are absorbed PO?

Answer 7

PCN -V
Oxacillin
Dicloxacillin
Amoxicillin
Ampicillin
\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_
All cephalosporins except
- Cefazolin (1st)
- Cefoxitin (2nd)
- Ceftriaxone (3rd)
\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_
Vanc when treating C.Diff

Question 8

Which cell wall synthesis inhibitors are administered IV?

Answer 8

PCN-G
Methicillin
Ticarcillin
Piperacillin (PIP-TAZO)
\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_
3 of the Cephalosporins:
- Cefazolin (1st)
- Cefoxitin (2nd)
- Ceftriaxone (3rd)
\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_
Carbapenems
\_\_\_\_\_\_\_\_\_\_\_\_\_
Vanc except for C. Diff

Pa-pa-sa-sa-va!

Question 9

Which protein synthesis inhibitors are absorbed PO?

Answer 9

All the protein synthesis inhibitors except:
Streptogamins
AGs

Question 10

Which protein synthesis inhibitors are administered IV?

Answer 10

Streptogamins

AGs

Question 11

Which inhibitor of DNA fxn are absorbed PO?

Answer 11

FQ
- Cip, Levo, Mox

Nitrofurantoin
Metronidazole

Question 12

Sulfonamides are absorbed PO or administered IV?

Answer 12

PO

Question 13

Drugs that distribute to CSF

Answer 13

PCN (if tissue is inflammed)
Ceftriaxone (3rd gen ceph)
Carbapenams
\_\_\_\_\_\_\_\_\_\_\_
Chloramphenicol
Metronidazole
Sulfonamides

Question 14

Drugs that distribute to urine

Answer 14

AG
FQ
- (Cip, Levo)
NF

Question 15

Drugs that distribute to bone

Answer 15

Clindamycin

Metrinidazole

Question 16

Drugs that distribute to lungs

Answer 16

Macrolides (ACE)
FQ
- Levo, Mox

Question 17

Drugs that distribute to bone (Bad)

Answer 17

TCN

Question 18

Drugs that distribute to teeth (Bad)

Answer 18

TCN

Question 19

Drugs that distribute to kidney (Bad)

Answer 19

AGs

Question 20

Drugs that contribute to 8th nerve damage (Bad)

Answer 20

AGs

Question 21

Drugs that distribute to fetus (Bad)

Answer 21

Cephalosporins
Macrolides (ACE)
TCN
\_\_\_\_\_\_\_\_\_\_\_\_\_\_
Sulfonamides

Question 22

Drugs that are eliminated Non-renally can cause what 3 negative side effects?

Answer 22

1. drug-drug interactions,
2. genetic polymorphisms in metabolizing enzymes, ]
3. potential for hepatotoxicity:

Question 23

List Drugs that are eliminated Non-renally

Answer 23

D - oxycyclin
Q - uinolones (mox)
C - lindamycin
R - rifampin
I - soniazid
M - etronidazole
E - rythromycin like drugs (ery and Azi are biliary excretion)
S - ulfonamides

Question 24

Which DQCRIME drugs are inhibitors of P450?

Answer 24

Quinolones

Erythromycin

Question 25

Which DQCRIME drugs are inducers of P450?

Answer 25

Rifampin

Question 26

Metronidazole and Erythromycin like drugs are at risk for DDI, but via different mechanisms. Explain

Answer 26

Metronidazole: drug-drug interaction with alcohol due to inhibition of aldehyde metabolism (Antabuse reaction) Erythromycin-like: drug-drug interactions due to inhibition of P450 (Clar-Ery not Azi)

Question 27

Renally excreted drugs

Answer 27

``` PCN Cephalosporins Carbapenams Vanc _________ AGs FQ (Cip, levo) ```

Question 28

-Cidal drugs

Answer 28

``` All the CW synth inhibitors ___________________ Oxazolidinones for strep Streptogamin (whn used synergistically w/ quinupristen) AGs ____________ All inhibitors of DNA fxn ```

Question 29

- Static drugs

Answer 29

``` Macrolides (ACE) Clindamycin Chloremphenicol Oxazolidinones TCN ``` - Basically All protein synthesis inhibitors except: Oxazolidinones for strep Streptogamin (whn used synergistically w/ quinupristen) AGs

Question 30

Which Protein synthesis inhibitors inhibit the 30s subunit?

Answer 30

TCN | AGs

Question 31

Narrow spectrum drugs list

Answer 31

PCN VANC AGs

Question 32

Extended spectrum drug list

Answer 32

``` Extended spectrum PCN Anti-pseudomonal (PIP/Tazo) Cephalosporin Carbapenam (wide spectrum) _____________ Macrolides FQ ```

Question 33

Broad spectrum drug list

Answer 33

Chloramphenicol TCN Sulfonamides