Moar cancer stuff PCN and CHL Flashcards Preview

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Flashcards in Moar cancer stuff PCN and CHL Deck (18):
1

Types of plasma cell neoplasm (PCN)

1. MGUS
2. Plasmacytoma
3. Plasma cell myeloma (Multiple myeloma)

2

Types of CHL

1. Nodular sclerosis
2. Mixed cellularity
3. Lymphocyte rich
4. Lymphocyte depleted

3

Findings in MGUS

Monoclonal Ig in serum or urine
M protein < myeloma levels
no lytic bone lesions

- NO CRAB symptoms/PCM evidence

4

MGUS is a precursor to...?

plasma cell myeloma (mult. myeloma)

5

Pt population of:
1. MGUS
2. Plasmacytoma
3. Plasma cell myeloma (Multiple myeloma)

1. MGUS: >50 yr
2. Plasmacytoma: 5 yr old, Male (2/3)
3. Plasma cell myeloma (Multiple myeloma): >50 yrs

6

Types of plasma cytoma

1. plasmacytoma of bone
2. extraosseous plasmacytoma

7

plasmacytoma of bone findings

local tumor of bone w/ multiple myeloma like cells
no other lesions
No M protein (like MGUS and PCM)

8

extraosseous plasmacytoma findings

local mass lesions outside of bone/BM w/ 75% in upper resp. tract

9

Plasma cell myeloma findings

CRAB:
high Ca2+, renal insufficiency, anemia, bone lesion

M protein in serum or urine (mostly IgG)
Elevated creatinine
Rouleux on smear

10

Most frequent symptom of Plasma cell myeloma (multiple myeloma)

bone pain (back/extremities),

weakness/tired

11

CHL driven by?

Hodgkin Reed sternberg cells (RS or HRS),
which are B cell derived

12

Common markers of CHL
positive for? negative for?

CD15, CD30

Neg: CD19, CD20, CD45

13

Histo of CHL

multilobular nucleus
eosinophilic inclusions
large cytoplasms

14

Breakdown % of CHL

1. Nodular sclerosis
- 50-80%
2. Mixed cellularity
- 20-30%
3. Lymphocyte rich
- 5 %
4. Lymphocyte depleted
- 1%

15

Target population of:
1. Nodular sclerosis
2. Mixed cellularity

1. Nodular sclerosis:
- young adults, females
2. Mixed cellularity:
- Kids/elderly

16

EBV predominance in CHL:
1. Nodular sclerosis
2. Mixed cellularity
3. Lymphocyte rich
4. Lymphocyte depleted

1. Nodular sclerosis
- EBV in 10-25%
2. Mixed cellularity
- EBV in 75%
3. Lymphocyte rich
- no EBV
4. Lymphocyte depleted
- EBV + usually

17

Whichh CHL is found to have broad collagen bands?

Nodular sclerosis

18

Which CHL is found to have nodular growth pattern with residual germinal centers?

Lymphocyte rich