Buzzwords

Question 1

Brushfield spots in the iris

Answer 1

Down syndrome

Question 2

Single palmar crease

Answer 2

Down syndrome

Question 3

Barr body

Answer 3

Klinefelter

Question 4

Gynecomastia

Answer 4

Klinefelter

Question 5

Silver-white scaly lesion

Answer 5

Psoriasis

Question 6

Neutrophils in the stratum corneum

Answer 6

Psoriasis

Question 7

multiple minute bleeding points

Answer 7

Psoriasis

Question 8

edema between keratinocytes

Answer 8

eczema

Question 9

Undulant epidermal hyperplasia

Answer 9

verrucae (common to both forms)

Question 10

Blue-gray elastic fibers

Answer 10

actinic keratosis

Question 11

Keratin pearls

Answer 11

squamous cell carcinoma

Question 12

elevated serum creatine kinase

Answer 12

muscular dystrophy

Question 13

dystrophin

Answer 13

Duchenne or Becker muscular dystrophy

Question 14

pseudohypertrophy of calves

Answer 14

Duchenne or Becker muscular dystrophy

Question 15

red granular stuff in sarcoplasm (ragged red fibers)

Answer 15

mitochondrial myopathy

Question 16

para-crystalline “parking lot inclusions” in the cristae of mitochondria

Answer 16

mitochondrial myopathy

Question 17

PAX3-FKHR gene fusion

Answer 17

rhabdomyosarcoma

Question 18

its worse to be a man

Answer 18

melanoma

Question 19

tadpole and strap cells

Answer 19

rhabdomyosarcoma

Question 20

a1 or a2 type 1 collagen mutation

Answer 20

osteogenesis imperfecta

Question 21

Blue sclera

Answer 21

Osteogenesis imperfecta TYPE 1!

Question 22

Point mutation (gain of function) in FGFR3

Answer 22

Achondroplasia

Question 23

Increased osteoclasts

Answer 23

Type 1 (postmenopausal) osteoporosis

Question 24

Dowager’s hump

Answer 24

aka kyphosis. Osteoporosis

Question 25

Decreased osteoblasts

Answer 25

Type 2 (senile) osteoporosis

Question 26

diffuse pain, aspirin doesn't help

Answer 26

osteoblastoma

Question 27

aspirin helps

Answer 27

osteoid osteoma

Question 28

central radiolucent nidus, rim of sclerotic bone

Answer 28

osteoid osteoma or osteoblastoma

Question 29

elevated serum alkaline phosphatase

Answer 29

osteosarcoma

Question 30

lifted periosteum --> Codman Triangle

Answer 30

osteosarcoma

Question 31

monosodium urate crystals

Answer 31

gout

Question 32

intraparenchymal vessel rupture

Answer 32

intracerebral hemorrhage

Question 33

berry aneurysm

Answer 33

subarachnoid hemorrhage

Question 34

middle meningeal artery rupture

Answer 34

epidural hematoma

Question 35

kicked in the side of the head

Answer 35

epidural hematoma

Question 36

fusiform and lenticular

Answer 36

epidural hematoma

Question 37

stroke from hypertension

Answer 37

intracerebral hemorrhage

Question 38

Pseudo-palisade arrangement of tumor cells

Answer 38

Glioblastoma multiforme

Question 39

whorled pattern of concentrically arranged spindle cells

Answer 39

meningioma

Question 40

psammoma bodies

Answer 40

meningioma

Question 41

gamma globulin in CSF

Answer 41

MS

Question 42

SORL-1

Answer 42

Late onset Alzheimer's

Question 43

E2

Answer 43

good

Question 44

E4

Answer 44

bad (Alzheimer's)

Question 45

Presinilin-1

Answer 45

Early onset Alzheimer's

Question 46

beta-amyloid

Answer 46

Alzheimer's

Question 47

tau protein

Answer 47

neurofibrillary tangle - Alzheimer's

Question 48

you get hit in the head, you think you are ok, then you die

Answer 48

epidural hematoma

Question 49

2/3 have mutated RB gene, many also have mutated p53

Answer 49

osteosarcoma

Question 50

acute hypocorticism

Answer 50

Waterhouse-Friderichsen syndrome (complication of bacterial meningitis)

Question 51

HPV 2, 4

Answer 51

verruca vulgaris

Question 52

HPV 3, 10

Answer 52

verruca plana

Question 53

mitotic figures above the basal layer

Answer 53

psoriasis

Question 54

thin or absent stratum granulosum

Answer 54

psoriasis

Question 55

neutrophils in stratum corneum

Answer 55

psoriasis