C: 1-4 Flashcards
Disinfection vs Sterilization
Disinfection; reduce amount of potential pathogenes
Sterilization: Removal. complete elimination
Disinfectant is on non living surface
Antidecptic on living surface
Antiseptics, etc.
Ethanol+isopropanol: Denature proteins( The second is more effective but also more dangerous)
Povidone iodine is Halogen: on skin
H2O2: Mouth wash, wounds
Chlorhexidone: Hospital scrub rutine. Ototoxicity!!
Octenidin
Invert soaps
TB drugs and CYP450
IIIIsoniazid inhibits
Rifampin enhances
RIPE SE
It’s shit of a disease so the drugs are super powerful! Shit to liver
זה חרא של מחלה אז התרופות סופר חזקות! חרא לכבד
hepatotoxicity
Rifampin- orange! nephro
Isoniazid- B6 defici. –> neuropathy, lupus, G6PD, metabolic acidosis
Pyrazinamide- dont give in pregnancy
Ethambutol- visual. E for Eye
More mycobacteria drugs
Streotomycin
Kanamycin
Cycloserine D-ala…
Leprosy Tx.
MOA
SE
Dapsone
Inhibit folic acid synthesis
Can also be given to AIDS pneumonia
G6PD
Methemoglobinemia
Acyclovir/val-
MOA
Usage
SE
Guanine analog Lacks -OH group at 3' end Monophosph. by viral enzyme Acyc- HSV Val- VZV V for V
Nephro and CNS
Gancyclovir
MOA
Usage
SE
Guanosine. 3Xphosp. by Kinase (UL97)
CMV
Bone marrow
Cidofovir
MOA
Usage
SE
Cytidine analog
CMV, HSV, HPV
CCCC
Nephro. Give with probenecid
Foscernat
MOA
Usage
SE
DNA/RNA pol inhib.
CMV for Gancyclovir resistant
Nephro and CNS
Pneumocyctic jirovecy tx.
Foscernat with Pentamidine
Influenza drug
MOA
Usage
SE
Oseltamivire
Neuroamenidase inhib.
GI
Anti RSV
Palivizumab- Anti fusion protein
Ribavirin- Like Guanisine. Can cause hemolytic anemia
General info on Direct acting antivirals
2-3 agents for 12-16 weeks for Hep. C
DAA
Protease inhib: Paritaprevir, Grazoprevir
Nucleoside polym. inhib: Sofosbuvir
NNPI: Dasabuvir
NS5A ibhib: Velpatsavir, Elbasavir
Traditional hepatitis Tx.
INFa- JAK STAT. Pegylated. CNS, Flu, Lupus
Entacavir- Guanosine analog
Tenofovir- Nucleotide. Nephrotoxicity
Malaria drugs
Chloroquine
Mefloquine is prophylaxis. vivid dreams
Quinine and Artesunate for severe infections
Lumefantrine causes QT prolongation
Atovaquone/Proguanil
Primaquinetreats liver phase of vivax/ovale and causes hemolysis in G6PD
Parazites and Helminths drugs
Metronidazole for parazites
Rest for helminths
Mebendazole inhibit microtubule and is teratogenic
Ivermactin (GABA)
Niclosamide is oxidative phosph. for Taenia
Antifungi
Ampho.B and Nystatin interacts with Ergosterol cause hypotension, Phlebitis, nephro, CNS
Azoles inhibit Ergosterol synthesis
Azole
C-FIV
Clotrimazole- topical! clothing is on top!
Fluconazole- BBB! meningitis…
Itraconazole- for dimorphic
Voriconazole- aspergillus. vortex! visual bad!!
More antifungi
Flucytosine –> 5FU inhibit Thymedilate synthase. give in meningitis with Ampho.B
Capsofungin- for cell wall. Candida.
Terbinafine- inhibits Squelane epoxidase. topical. for onychomycosis
Anti HIV drugs
NRTI
Ziduvodine
Lamivudine
Abacavir
Tenofovir
Which NRTI is the most toxic and why?
Ziduvodine
Bone marrow suppression
NNRTI
Etravirine
אתרע מזלו לא להיות NRTI
Do not require activation via phosphorylation
