C A N C E R

Question 1

Why is cholecystectomy recommended for those with porcelain gallbladder?

Answer 1

11-33% of this patient population will eventually develop gallbladder CA (mostly adenoma).

Question 2

Genetics of lynch syndrome

Answer 2

AD inherited cancer susceptibility caused by ag ermline mutation in one of DNA mismatch repair genes.

Question 3

Women with lynch syndrome have increased risk of which cancers?

Answer 3

27-71% of endometrial cancer and 3-14% risk of ovarian cancer.

Question 4

Endometrical cance screening in asymptomatic women with LYnch syndrome

Answer 4

Annual endometrial sampling starting at age 30-35 or 5-10 yrs prior to earliest age of Lynch-associated cancer of any kind in the family

Question 5

Lydia cell tumor

Answer 5

Most common testicular sex cord stream tumor, which may occur in all age groups, including young children. Lydia cells are principal source of testosterone and are capable of estrogen production, due to markedly increased aromatase expression. Estrogen production is markedly increased in tumorous growth, with secondary inhibition of LH and FSH levels. Endocrine mx found in 20-30%, most common being gynecomastia, but in prepubertal cases, precocious puberty is common

Question 6

Choriocarcinoma characteristic lab finding

Answer 6

Germ cell tumor characterized by increased serum beta-HCG concentrion

Question 7

Teratoma characteristic lab abnormalities

Answer 7

Elevation in AFP or beta-hCG indicating coexistence of other germ cell tumor components.