C. Diff Infectin o

Question 1

What is the most common HCA infection in the us

Answer 1

C.diff

Question 2

What types of toxins are A and B in c. Diff

Answer 2

A: Enterotoxins
B: cytotoxin

Question 3

Causes of c. Diff

Answer 3

Acquired exogenously
Bacteria carried in stool
Exposure to anti microbial agents-then toxin- then inadequate immune response

Question 4

Risk factors for c. Diff

Answer 4

Age, severity of underlying issues, GI sx, rectal thermometers, enteral tube feed, antacid treatment, antibiotics

Question 5

S/s of c diff

Answer 5

Diarrhea
Fever, ABD pain, leukocytosis
A dynamic illeus: high risk for toxic megacolon and sepsis
Fulminant cdiff: hypotension, shock

Question 6

Diagnosis and treatment of c diff include ABX taper

Answer 6

Diarrhea >3/24h for >2 days
Positive stool culture
D/C ABX
Hydration
Oral vanco or difficid
125mg po q6h x10days — 125 mg po BID x7 days — 125mg po qd x7 days — 125mg po qd q2-3 days x2-8 days

Question 7

Treatment for fulminant c diff

Answer 7

Oral Vanco 500mg po q6 plus Flagyl 500mg IV q8h
Consider vanco enema
May need fecal transplant