C2 - antiepileptics Flashcards Preview

Pharmacology Colloquium 3 > C2 - antiepileptics > Flashcards

Flashcards in C2 - antiepileptics Deck (15):
1

Zolmitriptane

A: triptane
B: agonist of serotonin R 5HT1D and 5HT1B
-> intracranial vasoconstriction
-> anti-inflammatory
C: migraine

2

Carbamazepine

A: antiepileptic, CYP-450 inductor (drug interactions)
B: inhibits uptake&release of Norepinephrine
blocks Na+ channels
-> reduce excitement of neurons
C: epilepsy: grand mal, partial/facial
manic episodes of bipolar disease

3

Phenobarbital

A: Antiepileptic, Barbiturate, sedative, CYP-450 inductor(drug interactions)
B: direct activation of GABA R
C: isomnia, epilepsy 2nd line for grand mal

4

Valproic acid

A: antiepileptic
B: increases levels of GABA in brain (Na+ and Ca2+ blocker)
C: epilepsy: grand mal, partial/facial, petite mal
manic episodes of bipolar disease
-> very teratogenic!

5

Gabapentine

A: Antiepileptic (new)
B: GABA analogue
C: epilepsy: partial/facial

6

Pregabaline

A: antiepileptic (new)
B: acting like GABA,
blocking glutamate,
Inhibits Ca2+ influx on presynaptic neuron
-> analgetic, anxiolytic, sedative
C: partial/facial epilepsy, neuralgia, anxiety

7

Lamotrigine

A: antiepileptic (new)
B: delays release of Glutamic acid and blocks Na+ channels
-> anticonvulsive
C: epilepsy: grand mal, partial/facial, petite mal
prophylaxis of depressive episodes in bipolar disease

8

Ethosuximide

A: antiepileptic, succimide
B: blocking Ca2+ channels
C: petit mal epilepsy

9

Trihexyphenidyl

A: antiparkinson, anticholinergic
B: anticholinergic, blocks muscarinic R
C: 1st line for tremor, also against side effects of anispychotics (extrapiramidal side effects)

10

Selegiline

A: Aniparkinson, MAO-inhibitor
B: inhibits MAO-B irreversible
and blocks dopamin degeneration
C: symptomatic treatment of parkinson
adjunctive therapy for patients with decreased response to levodopa-carbidopa
mono therapy in newly diagnosed parkinson

11

Levodopa/Benzerazid

Levodopa:
A: antiparkinson
B: crosses blood brain barrier (BBB) and converts to dopamin

Benzerazid:
A: decarboxylase inhibitor
B: decarboxylase is converting levodopa into dopamine. We need dopamine in CNS against parkinson BUT NOT in periphery (it causes side effects in periphery). Benzerazid does NOT cross BBB, thus it lets levodopa time to cross the BBB without being converted to dopamine too early (in periphery)
C: 1st line symptomatic treatment of early parkinson (most effective!)
1st line tremor treatment
idiopathic parkinson

12

Pramiracetam

A: nootropic drug, GABA derivative
B: imitate metabolic effects of GABA & normalize impaired cerebral function
C: cerebrovascular insufficiency,
improves memory & learning, cognitive impairment (especially in elderly), atherosclerosis of cerebral BV

13

Piracetam

A: nootropic drug, GABA derivative
B: imitate metabolic effects of GABA & normalize impaired cerebral function
increases cellular metabolism and oxygen supply of brain tissue
C: cerebrovascular insufficiency,
improves memory & learning, cognitive impairment (especially in elderly), atherosclerosis of cerebral BV

14

Phenibute

A: nootropic drug
B: GABA-B agonist (not GABA-A like benzodiazepines)
-> anxiolytic, neuroleptic
C: anxiety and insomnia in soviet union, dietary supplement (= increasing cell metabolism) in EU

15

Memantine

A: NMDA-antagonist
B: non-competitive NMDA-R antagonist (glutamate R excitation is reason for Alzheimer)
C: symptomatic treatment of medium-severe Alzheimer