C4 - Antidepressants/ ADD malarky Flashcards Preview

Pharmacology Colloquium 3 > C4 - Antidepressants/ ADD malarky > Flashcards

Flashcards in C4 - Antidepressants/ ADD malarky Deck (15):
1

Amitriptyline

A. Antidepressant/ SSNRI/ tricyclic
B. Neurotransmitters (NE/ serotonin) reuptake inhibitor increases concentration of neurotransmitter in CNS
block muscarinic R -> dry mouth
block alpha2 adrenogenic R
C. Depression
co-analgesic

2

Nortriptyline

A. Antidepressant/ TCA/ tricyclic / thymeretic (=psychomotor activating effect)
B. Neurotransmitter reuptake inhibitor increases concentration of neurotransmitters in CNS.
block muscarinic R -> dry mouth
block alpha2 adrenogenic R
C. Depression
co-analgesic

3

Paroxetine

A. Antidepressant/ SSRI
B. Little or no affinity for alpha adrenergic histamine or cholinergic receptor
C. Depression/ OCD

4

Escitalopram

A. Antidepressant/ SSRI
B. S-enantiomer of racemic citalopram inhibits the reuptake of serotonin with little or no effect on NE or dopamine re-uptake
C. Major depressive disorder.

5

Sertraline

A. Antidepressant/ SSRI
B. Selective serotonin re-uptake inhibitor little or no affinity for alpha adrenergic histamine or cholinergic inhibitor
C. Major depressive disorder

6

Mirtazapine

A. Anti-depressant/ Alpha2 antagonist/ sedative / tricyclic
B. Tetracycline structure different from SSRI, TCAs and MAOI through its central pre-synaptic alpha2 and adrenergic antagonistic effects. Stimulates NE and serotonin release, potent antagonists of 5HT2/3 and histamine H1
C. add-on medication (together with duloxetine, ventaxafine) for resistant depression treatment
Depression/ Post traumatic stress disorder

7

Duloxetine

A. Anti-depressant, SNIRS
B. Exact mechanism is unknown but serotonin and NE reuptake inhibitor
C. Major depressive disorder.
co-analgesic

8

Ventaxafine

A. Antidepressant
B. Inhibits the reuptake of both serotonin and NE with a potency greater for 5HT3 than NE reuptake process
C. Major depressive disorder

9

Bupropione

A. Antidepressant of aminoketone groups
B. Dopamine uptake inhibitor
(i) Selectively inhibits the neuronal re-uptake of dopamine NE and serotonin action on dopaminergic systems are more significant.
(ii) The increase in NE may attentuate nicotine withdrawal symptoms and increases in dopamine at neuronal site may reduce nicotine cravings and the urge to smoke
C. depression, smoking cessation

10

Agomelatine

A. Anti-depressant
B. Agonist at melatonin receptor MT1/ 2
Antagonist for serotonin 5ht 2 receptors
C. Major depressive disorder.

11

Methyl-Phenidate

A. Dopamine uptake inhibitor/ Amphetamine
B. Blocks NE and dopamine
(i) Blocks dopamine uptake in central adrenergic neurons by blocking dopamine transport or carrier proteins
(ii) Acts as a brain stem arousal system and the cerebral cortex and causes increased sympathomimetic activity in the CNS
C. ADD/ ADHD

12

Atomoxetine

A. SNRI
B. Inhibition of NE transporter increases NE concentration in the prefrontal cortex.
C. ADHD

13

Caffeine

A. Psycho-analeptic
B. Stimulation of the cerebral cortex, breathing, circulation dilation of BV, diuresis
C. Fatigue

14

Baclofenam

A. Muscle relaxant
B. Stimulation of GABA R supresses spinal reflex
C. Muscular and spinal spasms of muscular contractions.

15

Tolperisone

A. Muscle relaxant
B. Inhibition of Na+ and Ca++ channels suppresses spinal reflex
C. Spasms after stroke.