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GI Micro > Campylobacter > Flashcards

Flashcards in Campylobacter Deck (15)
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1

T or F. Is the most common bacterial GI infection in developed nations.

T

2

How many cells are needed for infection?

Only a few hundred

3

What animals are the reservoirs?

Sheep, cattle, chickens, wild birds, and dogs

4

What are the most common sources?

1. Undercooked poultry
2. Unpasteurized milk
3. Contaminated water

5

Shape?

Thin, spiral Gram Negative rods. "Gull-winged" appearance.

6

Oxygen requirements?

Microaerophilic

7

How long is the incubation period?

1 week

8

What other pathology can an infection mimic?

Appendicitis

9

Clinical presentation?

1. Fever, appendicitis-like lower abdominal pain
2. Watery diarrhea that progresses to dysentery w/ blood and pus

10

Is the most common antecedent to what syndrome? Why does this occur?

Guillain-Barre syndrome. Cross-reactive antibodies to C. jejuni's lipooligosaccharides and myelin (molecular mimicry).

11

What's the usual course of the infection?

Self-limiting w/ resolution in 3-7 days

12

Diagnosis?

Culture on media containing abx preventing growth of resident bowel flora

13

Treatment for prolonged infections?

Erythromycin (also fluoroquinolones but resistance increasing)

14

What class of abx is it resistant to?

Beta-lactams

15

Why are C. jejuni infections self-limiting while H. pylori infections can last for decades?

Campylobacter works in lower GI tract where there's a good mechanical clearance process (aka shitting). H. pylori makes its own suitable environment and able to establish infection for a long period of time.