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NAVLE > Cancer > Flashcards

Cancer Flashcards

1
Q

Breaks strands of DNA

A

Alkylating agents

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2
Q

Cyclophosphamide
Melphalan
Chlorambucil
Lomustine

A

Alkylating agents

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3
Q

Interfers with topoisomerase

A

Anti-tumor abx

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4
Q

Anthracycline (Doxoubicin)

Epirubicin

A

Anti-tumor abx

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5
Q

Inhibits mitosis

A

Mitotic inhibitors

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6
Q

Vincristine
Vinblastine
Paclitaxel

A

Mitotic inhibitors
First 2 are plant alkaloids
Last inhibits disassembly of DNA

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7
Q

Cross linked DNA

A

Platinum drugs

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8
Q

Carboplatin

A

Platinum drug

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9
Q

Incorporates into DNA during transcription and translation specifically works on S-phase

A

Anti-metabolites

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10
Q

Methotrexate
Cystosine
5-flurouricil
6-mercaptopurine

A

Anti-metabolites

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11
Q

Inhibits cell signaling for cell proliferation

A

Tyrosine Kinase Inhibitors

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12
Q

Toceranib

Mastitinib

A

TKIs

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13
Q

What drug would you use to treat TVT?

A

Vincristine

Rapidly dividing tumor

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14
Q

What drug would you use to treat leukemia?

A

Hydroxyurea

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15
Q

What drug would you use to treat osteosarcs?

A

Carboplatin

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16
Q

What drug would you use to treat non-osteo sarcomas?

A

Doxorubicin

17
Q

What is the COP protocol and what is the benefit of it?

A

Cyclophosphamide
Vincristine
Pred

Designed to have lower toxicity and fewer side effects

18
Q

What is the COP protocol for?

A

Cancer with poor survival=palliative tx

19
Q

What is the CHOP protocol?

A

Cyclophosphamide
Doxorubicin
Vincristine
Pred

High toxicity and severe side effects

NAVLE (7 decks)

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