Cancer

Question 1

Prevalent toxicities BCDMN

IP

VT

BMS

Answer 1

• Bleomycin, busulfan, carmustine, lomustine
• Cisplatin, carboplatin: nephro/ototox
• Doxorubicin and other anthracyclines: cardiotoxic
• MTX: Mucositis
• Nitrosoureas (lomustine, carmustine: hemorragic cystitis
• Vinc and taxanes: peripheral neuropathy
• Bone marrow suppression (BMS)

Question 2

What are the age ranges for breast cancer screenings?

Answer 2

40-44

45-54

>=55

Question 3

Diarrhea 3 drugs

Answer 3

Fluorouracil, capecitabine, irinotecan

I Flu to CAPE cod and RAN TO THE CAN

Question 4

Mucositis

4 main meds and this class that ends in what?

Answer 4

Fluorouracil

capecitabine

irinotecan

MTX

TKIs end in nib

Question 5

Neuropathy

3 classes

3 drugs

2

3

Answer 5

Vinca alkaloids, Vinecristine, vinblastine, vinorelbine

Platinums: cisplatin, oxaliplatin

taxanes: Paclitaxel, docetaxel, cabazitaxel

Question 6

When should a 43 yo female get a mammogram?

Answer 6

Annual mammograms are optional

Question 7

Nausea and Vomiting

What 3 drugs cause N/V the most?

Answer 7

Cyclophosphamide, cisplatin. ifosfamide

Question 8

Thromboembolic risk

Answer 8

SERMS and aromatase inhibitors (anastrozole, letrozole)

SERMS: Tamoxifen

Question 9

Lung cancer age range for screening?

Answer 9

55-74

Question 10

Myelosuppression

Most chemo drugs do but what three dont?

Answer 10

Almost all expect Bleomycin, aspariginase, and vinctristine

Question 11

Hemorragic cystitis

2 drugs and specific dosing

Answer 11

Ifosfamide: all doses

Cyclophosphamide: hgiher doses> 1 gram/m2V

Question 12

When should a 47 yo get a mammogram?

Answer 12

Begin yearly mammograms

Question 13

WHen should a 57 yo F get mammograms?

Answer 13

q 2 years or continue annually

Question 14

Cardio toxicities

2 categories

1 in one cat

2 in the other

Answer 14

Anthracyclines cardiomyopathy

arsenic trioxide, TKIs ending in nib: QT prolongation

Question 15

Constipation

Answer 15

Vinecristine

Question 16

What is the criteria for getting a annual CT scan of the chest?

Answer 16

• In good health
• Have at least a 30 pack-year smoking history
• Still smoking or quit smoking within the past 15 years

Question 17

Hepatotoxicity

Specific class and 3 within

Answer 17

Antiandrorgens (bocalutamide, flutamide, nilutamide)

Question 18

Lifetime cumulative dose is 450-550 mg/m2 what is the drug and the reason?

Answer 18

Doxorubicin reason is cardiotoxicity

Question 19

Single dose is capped at 2 mg what is the drug and the reason?

Answer 19

Vincristine and Neuropathy

Question 20

Nephrotoxicity 2

Answer 20

Cisplatin, and MTX

Question 21

When should a 47 year old pt get a colonoscopy?

Multi targeted DNA stool test?

Answer 21

Every 10 years

Stool every 3 years

Fecal occult blood test every year

Flexible sigmoidalscopy every 5 years

Question 22

Dose per cycle is not to exceed 100 mg/m2

Answer 22

Cisplatin and nephrotox

Question 23

Pulmonary toxicities

4

Answer 23

Bleomycin, busulfan, carmustine, lamustine

Question 24

Lifetime cumulative dose is 400 units what is the reason and drug?

Answer 24

Bleomycin reason is pulmonary toxicity

Question 25

What four chemo drugs commonly cause pulmonary fibrosis?

Answer 25

Bleomycin, Busulfran, Carmustine, Lamustine

Question 26

What two drugs are nephro and ototoxic

Answer 26

Cisplatin, ototoxic

Question 27

Cardio toxicity

Answer 27

Doxorubicin, and anthracyclines

Question 28

Methotrexate

Answer 28

Mucositis

Question 29

Hemorhagic cystitis

Answer 29

Nitrosuruea Carmustine, Lamustine Ifosfamide, Cyclophosphamide

Question 30

Peripheral neuropathy

Answer 30

Vincas, Taxanes

Question 31

What adjunctive medication is used for cisplatin and what does it prevent?

Answer 31

Amifostine (Ethyol)

Question 32

What adjunctive medications are used for doxorubicin and what does it prevent?

Answer 32

Dextrazoxane (Zinecard) To prevent cardiomyopathy Dextrazoxane (Totect) to treat extravasation

Question 33

What is given with fluorouracil adn what does it do?

Answer 33

Leucovorin to enhance efficacy

Question 34

What is the antidote for fluorouracil and capecitabine?

Answer 34

Uridine triacetate

Question 35

What is added to ifosfamide and what is it for?

Answer 35

Mesna to prevent hemorrhagic cystitis

Question 36

What can you do with cisplatin and ifosfamide?

Answer 36

Cisplatin to prevent nephrotoxicity Ifosfamide to prevent cystitis