Cancer/Antifungals/Dermatology/Antivirals/Herbals Flashcards by Jayson Welker

Fluconazole

Diflucan

Renal Elimination
Good/Excellent CSF penetration
QT prolongation
CYP450 Inhibitor

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Itraconazole

Sporanox

Hepatic Elimination
Highly protein bound
Poor CSF penetration
QT prolongation
CYP450 Inhibitor

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Ketoconazole

Nizoral

Hepatic Elimination
Highly protein bound
Poor CSF penetration
Impotence, decreased libido, gynecomastia

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Voriconazole

Vfend

TOES
Hepatic Elimination
Good CSF penetration
Transient visual disturbances (30 minutes)
CYP450 Inhibitor

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Posaconazole

Noxafil

Take with high fat meal
Hepatic Elimination
Highly protein bound
Poor CSF penetration
QT Prolongation
CYP450 Inhibitor

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Isavuconazonium

Cresemba

Excellent oral absorption
Hepatic Elimination
Highly protein bound
Poor CSF penetration
QT Prolongation
Optic neuropathy
CYP450 Inhibitor/Inducer

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Caspofungin

Cancidas

Echinocandin

Fungicidal - Candida
Fungistatic - Aspergillus

Highly protein bound
Poor CSF penetration
DON’T INHIBIT/INDUCE CYP450

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Micafungin

Micamine

Echinocandin

Fungicidal - Candida
Fungistatic - Aspergillus

Highly protein bound
Poor CSF penetration
DON’T INHIBIT/INDUCE CYP450

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Anidulafungin

Eraxis

Echinocandin

Fungicidal - Candida
Fungistatic - Aspergillus

Highly protein bound
Poor CSF penetration
DON’T INHIBIT/INDUCE CYP450

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Amphotercin

Fungicidal against most fungal pathogens

Highly protein bound
Poor CSF penetration
Extensive tissue distribution (long 1/2 life)

Nephrotoxicity - lipid assoc. formulations have less

Glomerular = decreased GFR/renal blood flow, azotemia
Tubular = hypokalemia, hypomagnesemia

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Flucytosine

DON’T USE AS MONOTHERAPY

synergy with ampho B and azoles against yeasts

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Terbinafine

Lamisil

inhibits squalene epoxidase leading to accumulation of the sterol squalene, which is toxic to fungal cell

Hepatotoxicity
Inhibits CYP450

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Griseofulvin

Fungistatic

Administer with high fat foods

CYP450 Inducer

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Nystatin

Topical use only

Use: local candida infections

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Bacitracin

Antibacterial

used temporarily for decreasing colonization of staph

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Polymyxin B Sulfate and Neomycin

Antibacterial

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Mupirocin and Retapumulin

Antibacterial

Mupirocin: impetigo caused by S. aureus or group A beta-hemolytic strep, intranasal preparation for decreasing MRSA colonization

Retapumulin: Group A beta-hemolytic strep - S. aureus including MRSA

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Retinoic acid

Tretinoin

TERATOGENIC

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Adapalene

Differin

Retinoid derivative

TERATOGENIC

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Tazarotene

Tazorac

Retinoid derivative

TERATOGENIC

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Azelaic acid

Azelex

Retinoid derivative

TERATOGENIC

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Benzoyl peroxide

MOA: peeling and comedolytic effects

Can cause bleaching of hair and clothing

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Vinca Alkaloids

Vincristine
Vinblastine
Vinorelbine

Bind tubulin and disrupt microtubule assembly

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Taxanes

Study These Flashcards

Paclitaxel
Docetaxel
Cabazitaxel

Stabilization of microtubules

ADR - infusion reactions, peripheral neuropathy/edema, alopecia, myelosuppression

Epipodophyllotoxins

Etoposide Teniposide Inhibit Topoisomerase II

Camptothecins

Irinotecan Topotecan Inhibit Topoisomerase I

Folate antagonists

Methotrexate | Pemetrexed

Purine Analogues

``` Cladribine Mercaptopurine Fludarabine Pentostatin Thioguanine ```

Pyrimidine Analogues

Cytarabine Fluorouracil - adjusted for renal dysfunction (IV) Capecitabine - adjusted for renal dysfunction (Oral) Gemcitabine Decitabine Azacitidine

Nitrogen Mustards

Cyclophosphamide - hemorrhagic cystitis, methylene blue= antidote Ifosfamide - hemorrhagic cystitis, methylene blue= antidote Melphalan Bendamustine

Nitrosureas

Carmustine | Lomustine

Triazenes

Dacarbazine | Temozolomide

Platinum Agents

Cisplatin Carboplatin Oxaliplatin

Anthracyclines

``` Doxorubicin Daunorubicin Epirubicin Idarubicin Mitoxantrone ```

Abiraterone (Zytiga)

Androgen Synthesis Inhibitor highly lipid soluble - TAKE WITH HIGH FAT MEAL mineralocorticoid storm - blockade pushes synthesis towards production of aldosterone

Tamoxifen (Nolvadex)

Selective Estrogen Receptor Modulator (SERM) Endoxifen (tamoxifen active metabolite) is 1000x more potent so avoid concomitant use!

Aromatase Inhibitors

Anastrazole (Arimidex) Exemestane (Aromasin) Letrozole (Femara) ONLY USE IN POST-MENOPAUSAL WOMEN

LHRH Agonists

Goserelin (Zoladex) Leuprolide (Lupron) Triptorelin (Trelstar) causes initial surge in testosterone/estradiol production leading to negative feedback based inhibition of the hypothalamus which could worsen symptoms associated with disease

Monoclonal Antibodies

Receptor complex blockade Antibody-dependent cellular cytotoxicity (ADCC) Complement-dependent cytotoxicity (CDC) Antibody-dependent cellular phagocytosis (ADCP) Targeted delivery of cytotoxic molecules Targeted delivery of radiation

Cluster of Differentiation (CD) 20 Inhibitors

Rituximab (Rituxan) - oncology and non-oncology Ofatumumab (Azerra) - oncology only Obinutuzumab (Gazyva) - oncology only

Tyrosine Kinase Inhibitors

target intracellular components name ends in -mib or -nib

Checkpoint Inhibitors

PD1 - 2nd checkpoint turns off activated T-cells at site of action PD2 - 1st checkpoint turns off T-cell activation in the lymph nodes

Osteltamivir (Tamiflu)

Treatment - 75mg BID x5 Prevention - 75mg QD x7-10 ADR - vomiting AVOID LIVE VACCINES X 2 WEEKS

Zanamivir (Relenza)

Treatment - 10mg BID x5 Prevention - 10mg QD x10 ADR - bronchospasm/neuropsychiatric - AVOID IN ASTHMA/COPD

Peramivir (Rapivab)

600mg IV over 15 minutes

Adamantanes (Amantadine and Ramantadine)

no longer recommended by CDC due to high resistance

Triumeq

Dolutegravir/abacavir/lamivudine

Genvoya

Emtricitabine/tenofovir alafenamide fumarate (TAF) /elvitegravir/cobicistat TWF

Stribild

Emtricitabine/tenofovir diproxil fumarate (TDF) /elvitegravir/cobicistat TWF

Complera

emtricitabine/TDF/rilpivirine TWF - 390 calories

Odefsey

emtricitabine/TAF/rilpivirine TWF - 390 calories

Truvada

emtricitabine/TDF

Descovy

emtricitabine/TAF

Atripla

emtricitabine/TDF/efavirenz

Tivicay

dolutegravir

Prezista

darunavir

Harvoni

ledipasvir-sofosbuvir

Epclusa

sofosbuvir-velpatasvir

Sovaldi

sofosbuvir

Cancer/Antifungals/Dermatology/Antivirals/Herbals Flashcards

(59 cards)