Cancer Drugs

Question 1

Antimetabolites (Pyrimidine syn)

Answer 1

Methotrexate–>DHFR
5-FU–> pyri. analong—> inhibits thymidylate synthase
Hydroxyurea—> Ribonucleotide reductase–> no deoxy pyrimi.

S phase

Question 2

Antimetabolite (Purine syn)

Answer 2

Azathioprine + 6-mercaptopurine—>HGPRT

Mycophenolate mofetil—> no GMP

S phase

Question 3

Antimetabolite (DNA pol. inhibitors

Answer 3

Cladribine–>Purine analog
Cytarabine—>pyrimidine analog
Gemcitabine –>pyrimidine analog

-bine ending

S phase

Question 4

Alkylating Agents

Answer 4

Cyclophosphamide
Nitrosoureas (-mustin/streptozotozin)
Busulfan

all cause DNA strand crosslinking

Question 5

Platins

Answer 5

All cause DNA crosslinking
contain platinum

Cisplatin
Carboplatin
Oxaliplatin

Question 6

Cytotoxic Drugs

Answer 6

Bleomycin–>free radical gen.–>dmg’s DNA
Doxorubicin–> free radical gen. + DNA intercalation (G-C)
Actinomycin D–> DNA Intercalation (A-T)

Question 7

Common toxicities of anthracyclines

Answer 7

Dilated cardiomyopathy

Question 8

Common toxicities of bleomycin

Answer 8

Pulmonary toxicities

Question 9

Common toxicities of cisplatin

Answer 9

Nephrotoxicity
ototoxicity
peripheral neuropathy

Question 10

Common toxicities of Cyclophosphamide

Answer 10

Hemorrhagic cystitis
Renal cancer

Question 11

Common toxicities of paclitaxel

Answer 11

Peripheral neuropathy

Question 12

Common toxicities of vincristine/vinblastine

Answer 12

Peripheral neuropathy

Question 13

What drugs inhibit vit K carboxylation

Answer 13

Warfarin

Question 14

What drugs increase antithrombin III activity

Answer 14

Heparin

Question 15

What drugs directly bing to factor Xa

Answer 15

Apixaban
Rivaroxaban

Question 16

What does the med PCC stand for

Answer 16

Prothrombin complex concentration

Question 17

What reverses Heparin

Answer 17

protamine sulfate

Question 18

What reverses walfarin

Answer 18

PCC and Vit K injection

Question 19

What reverses apixaban

Answer 19

Andexanet (Modified Factor Xa) and PCC

Question 20

Rituximab MOA

Answer 20

MOA: Targets CD20 on B-cells, inducing cell lysis.

Question 21

Cetuximab MOA

Answer 21

MOA: EGFR-targeting monoclonal antibody.

Question 22

Bevacizumab

Answer 22

MOA: Inhibits VEGF, preventing angiogenesis.

Question 23

Alemtuzumab

Answer 23

MOA: Targets CD52 on B and T lymphocytes, depleting immune cells.

Question 24

Trastuzumab

Answer 24

MOA: Binds HER2/neu receptor, preventing receptor activation.
treats breast cancer

cardiotoxic

Question 25

Erlotinib

Answer 25

MOA: EGFR tyrosine kinase inhibitor.

Question 26

Sunitinib

Answer 26

MOA: Inhibits multiple receptor tyrosine kinases, including VEGFR, PDGFR, and c-Kit.

Question 27

Sorafenib

Answer 27

MOA: Inhibits RAF, VEGFR, and PDGFR, interfering with tumor growth and angiogenesis.

Question 28

Vemurafenib

Answer 28

MOA: Inhibits BRAF V600E mutation in melanoma.

Question 29

what treats hairy cell leukemia

Answer 29

Cladribine

Question 30

What treats APL

Answer 30

ATRA

Question 31

what treats CML

Answer 31

imatib

Question 32

What treats follicular lymphoma

Answer 32

rituximab

Question 33

What type of vasculitis present with recurrent oral and genital ulcers, uveitis and POSITIVE pathergy test?

Answer 33

Behcets syndrome