Cancer Oncogenes and tumour suppressor genes Flashcards Preview

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Flashcards in Cancer Oncogenes and tumour suppressor genes Deck (3)
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1

Examples of oncogenes

EGFR, Her-2
SOS
ERK
Ras
c-Myc
cyclin D1
Raf

2

Examples of tumour suppressor genes

p53 (only one allele needs to be defective so shows oncogenic nature but is TSG as it inhbits proliferation)
APC
Fas receptor
PTEN
BRCA1
pRB
CIP/KIP family eg p27KIP1

3

Tumour suppressor gene definition

Genes involved in