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SBL > Cancer Pharmacology - Natural Products > Flashcards

Cancer Pharmacology - Natural Products Flashcards

(22 cards)

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1
Q

What are 2 Vinca Alkaloids?

A

Vinblastine

Vincristine

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2
Q

What are 2 Vinca Alkaloids?

A

Vinblastine

Vincristine

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3
Q

Vinblastine and Vincristine act during which cell cycle phase?

A

M phase

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4
Q

MOA for Vinca Alkaloids (Vinblastine and Vincristine)

A

Binds to beta-tubulin to (-) microtubule assembly

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5
Q

Adverse effects of Vinca Alkaloids (Vinblastine and Vincristine)?

A

Alopecia

Bone marrow suppression

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6
Q

Vinblastine major side effect?

A

Myelosuppression

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7
Q

Vincristine major side effect?

A

Neurological toxicities

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8
Q

What is 2 Taxanes?

A

Paclitaxel

Carbazitaxel

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9
Q

What is 2 Taxanes?

A

Paclitaxel

Carbazitaxel

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10
Q

Paclitaxel acts during which cell cycle phase?

A

M phase

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11
Q

MOA for Paclitaxel (taxane)

A

Binds to beta-tubulin and (+) microtubule assembly

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12
Q

Adverse effects of Paclitaxel?

A

Hypersensitivity reactions to hands/toes and changes in taste

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13
Q

What is 1 Camptothecin?

A

Topotecan

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14
Q

What is 1 Camptothecin?

A

Topotecan

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15
Q

MOA for Topotecan

A

(-) Topoisomerase 1

= DNA damage and cell death

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16
Q

Adverse effect of Topotecan?

17
Q

What can treat the adverse side effect of Topotecan?

Study These Flashcards
A
  • Diarrhea

= Atropine

18
Q

What is 1 Epipodophyllotoxin?

19
Q

What is 1 Epipodophyllotoxin?

20
Q

MOA for Ectoposide?

Study These Flashcards
A

(-) Topoisomerase 2

= DNA damage

21
Q

P-Glycoprotein often confers resistance to natural product chemotherapeutics. What Taxane can avoid this?

Study These Flashcards
A

Carbazitaxel (taxane)

22
Q

P-Glycoprotein often confers resistance to natural product chemotherapeutics. What drug can avoid this?

Study These Flashcards
A

Carbazitaxel (taxane)

SBL (48 decks)

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