Skin cancer and Alopecia Treatments Flashcards
(27 cards)
What 2 drugs can treat Basal/Squamous cell carcinomas?
Vismodegib
Sonidegib
What 2 drugs can treat Basal/Squamous cell carcinomas?
Vismodegib
Sonidegib
MOA for Vismodegib and Sonidegib?
Inhibits hedgehog pathway
These drugs inhibit the hedgehog pathway to treat basal/squamous cell carcinomas
Vesmodegib
Sonidegib
What 2 drugs can treat Melanoma?
Dacarbazine
Vemurafenib
What 2 drugs can treat Melanoma?
Dacarbazine
Vemurafenib
Conventional chemo treatment for Melanoma?
Dacarbazine
Dacarbazine treats?
Melanoma
- conventional chemo treatment
MOA for Vemurafenib
Inhibits MAP kinase pathway = apoptosis
What drug for Melanoma inhibits the MAP kinase pathway to cause apoptosis?
Vemurafenib
First line of treatment for Alopecia (male and female)?
Minoxidil
MOA for Minoxidil
Vasodilates due to K+ channel opening
What does Minoxidil cause?
Increased growth phase
Reduced rest phase
Enlargement of follicles
First line of treatment for Alopecia (male and female)?
Minoxidil
This drug causes vasodilation due to K+ channel opening
Minoxidil
What other drugs are available to treat Alopecia besides Minoxidil?
Finasteride
Spironolactone
Flutamide
MOA for Finasteride
Inhibits Dihydroxytestosterone (DHT)
Adverse effects of Finasteride
Sexual dysfunction – due to (-) DHT
What is an androgen partial agonist to treat female hair loss?
Spironolactone
What drug to treat Alopecia inhibits DHT?
Finasteride
What is Alopecia Areata?
Immune mediated inflammatory disorder that causes non-scarring hair loss from many locations
What is Alopecia Areata?
Immune mediated inflammatory disorder that causes non-scarring hair loss from many locations
What is the topical treatment for Alopecia Areata?
Diphenylcyclopropenone (DPCP)
What is the topical treatment for Alopecia Areata?
Diphenylcyclopropenone (DPCP)
