Cancers Flashcards
(18 cards)
AML
CD13, CD33, CD34, CD117, DLA-DR, MPO
Greater than 20% blasts
Good = NMP1
Bad = C-MYC
APL
CD33, MPO
DIC if not treated with ATRA
t(15:17) PML-RARA
Auer rods
ALL
General = CD34, TdT
Greater than 20% blasts
Normocytic anemia, thrombocytopenia, and lytic bone lesions
B-ALL
CD34, TdT, CD10, CD19, CD22, CD79a
Most common childhood malignancy
Good: t(12:21), hyperdiploidy
Bad: t(9:22) t(1:19), hypodiploidy
T-ALL
CD34, TdT, CD2, CD3, CD7
NOTCH pathway
Mediastinal masses
CML
CD13, CD33
t(9:22) BCR-ABL Philadelphia chromosome
Mature clones
Left shift leukocytosis, eosinophilia, BASOPHILIA, normocytic anemia, thrombocytosis, hepatosplenomegaly
CLL/SLL
CD5, CD19, CD23
BCL2 overexpression
Good: 13q deletion, mutated IgVH
Bad: 17p deletion, unmated IgVH
Disease of elderly, lymphadenopathy, cytopenias
CLL = leukemic, SLL = lymphoma
Burkitt Lymphoma
CD10, Ki-67
t(8:14), C-MYC
Associated with EBV, starry sky
Follicular Lymphoma
CD10, CD19, CD20, BCL2
t(14:18), BCL2 expression
Indolent
Mantle Cell Lymphoma
CD5, cyclin D1
t(11:14), associated with GI tract symptoms
Marginal Zone Lymphoma (MALT)
CD19, CD20, CD22
Associated with H. pylori
DLBCL
CD20
Possible double hit - C-MYC & BCL2 (bad)
Aggressive, most common NHL
ATLL
CD4
Cloverleaf, flower nucleus
Splenomegaly, lymphadenopathy, skin lesions, lytic bone disease
B-PLL
CD20, Ig
Hairy Cell Leukemia
CD11c, CD25, CD103, FMC7, TRAP
Cytopenia, hairy cell, marrow fibrosis - dry tap
LGLL
CD2, CD3, CD5, CD7
T cell or NK cell origin
Mycosis Fungoides
CD3, CD4, CD8
T cell lymphoma of skin, cerebriform nuclei
Can progress Sezary syndrome
Hodgkin’s Lymphoma
CD30, CD15
Reed-Sternberg cells
Lymphadenopathy, B symptoms
