Myeloproliferative Disorders Flashcards by Diarratou Kaba

Q

Polycythemia vera

A

Increased RBC/Hb/Hct/uric acid

Hypercellular BM

JAK 2 mutation

Phlebotomy, myelosuppression

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Q

Essential thrombocythemia

A

Increased platelets, giant megakarycotyes

Splenomegaly

JAK2, CAL4, MPL mutation

Myelosuppression, platelet pheresis

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Q

Myelofibrosis

A

Increased fibroblasts

Fibrotic BM, massive splenomegaly, teardrop cells

JAK2, CALR mutation

Jakafi = Jak2 inhibitor, splenectomy

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Q

CML

A

Increased granulocytic precursor

Ph chromosome - BCR-ABL

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Q

Myeloproliferative Disorders

A

Can progress to AML

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