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Flashcards in cancers Deck (19):
1

CML

myeloproliferative disorder

pluripotent stem cell

9:22, BCR-ABL - Ph22, P210

imatinibi

basophila

chronic - accelerated (10-20% blasts) - blast crisis (AML or ALL)

2

PV

JAK2 (crhom 9)

ruxolitinib

hypervisc syndrome with decreased EPO

prolif phase - spent phase - post poly myelofibroisis - AML(2%)

3

primary myelofibrosis

megakaryocyte cancer

JAK2, calreticulin, MPL

tear drop RBC

treat with ruxolitinib

4

essential thormbocytosis

megakaryocyte cnacer

JAK2, calreticulin, MPL

erythromelagia = hands and feet = red

5

mastocytosis

C-Kit mutation

uticaria pigmentosa

6

AML

t(15:17) = promyolcytic leukemia = ATRA, risk of DIC

auer rods = myeloid blasts

IP: CD34+, 13+, 33+, 117+, TdT-

 

7

ALL

childhood

bone pain

may or may not see blasts in blood

TdT+, SIg-

t(9:22)-Ph+, t(4:11), t(12;21)

hyperdiploidy (51-65) = good prog

8

CLL/SLL

post germ center memory B cell 

smudge cells

CD19+, 20+, 5+, 10-, SiG+

mutated IgVh gene = good prog

treat when symptomatic

transformations: richer (diffsue large B cell lymphoma), polymorphocytic (larger cells in circ)

9

Hairy cell

 

post germ center B cells

fried egg, reticulin fibrosis

CD 19+, 20+, 5-, 10-, SIg+

CD11c+, 25+, 103+, annexin A+

BRAF mutation

spleen involvemnt always 

10

follicular lymphoma

germ center B cells

t(14:18) = overexpress BCL2

no tingible body macs

CD 19+, 20+, 5-, 10+, SIg+

11

Diffuse large B cell lymphoma

centroblasts (in GC) or extrafolliuclalr B lymphoblasts (more aggressive)

extranodal presentation

aggressive

CD 19+, 20+, 5-, 10+/- (could be the same as follicular lymphoma but can tell by morphology)

 

12

plasma cell myeloma

CRAB (inc Ca, renal probl (bence jones prot), anemia, bone lesions

rouleaux formation

paraprotien

autologous SC transplant

MGUS - 1% transform each year 

13

Burkit lymphoma

early GC b cell

endemic, sporadic (US), HIV assoicated 

EBV association

tingible body macs = starry sky pattern 

t(8;14), t(2:8), t(8:22)

C-MYC 

CD 19+, 20+, 5-, 10+, SIg+, TdT- (tells you its not ALL or AML)

fastest growing

14

mantle cell lymphma 

 

pre GC B cell (naive B cell)

CD 19+, 20+, 5+, 10-, SIg+, 

cyclin D1+

t(11:14)

15

mycosis fungiodes

T cell neo

patch-plaque- nodule

pautrer microabscesses

sezary syndrome - circulating lymphoid cells in blood

cerebraform nuc on smear 

16

adult T cell lekumia/lymphoma

HTLV1 DNA test to diag

flower nuc on smear

17

anaplastic large T cell lymphoma

CD30+

t(2:5)

multilobated nucs in horse shoe

18

Hodgkin lymphoma

young adults

reed stern cells (owl eyes)

A symptoms (LAD, splenomegaly), B symptoms (fever, night sweats, weight loss)

CD 15+, 30+, 20-, Ig-

NF-kB acitavtion

nodular sclerosis (fibrous tissue), mixed cellularity (no fib), lymphocyte depletion, lymphocyte rich (rare)

19