Cancers and other immune conditions Flashcards
What is the most common childhood malignancy?
ALL
What are some symptoms that a child with leukemia might present with?
Anorexia, bone pain, fever, pancytopenia, easy bruising, HSM
A greenish, soft tissue tumor on the skin or spinal cord is called? What is the underlying cause?
Chloroma
AML
Children who receive chemotherapy for leukemia are at an increased risk for?
Tumor lysis syndrome
What lab abnormalities are associated with tumor lysis syndrome?
elevated potassium and phosphorus
Low uric acid and calcium
What are the consequences of untreated tumor lysis syndrome?
ARF, arrhythmias, and death
Neuroblastoma’s are associated with?
NF1, Hirschsprung, N-myc oncogene
By the time neuroblastomas are found there is usually a metastasis present. What are the most common metastases?
- Abdominal masses and hepatomegaly
- Thoracic tumors and horner syndrome
- Cervical cord compression with myoclonus
Neuroblastomas would have this urinary finding?
increased urinary catecholamines
What is the anatomical rule with wilm’s tumors?
They do not cross midline
Beckwith-Widemann syndrome presents with what three symptoms?
- hemihypertrophy
- macroglossia
- visceromegaly
Kawasaki Disease is common in what ancestry?
Asian
Describe the acute, subacute, and chronic processes of Kawasaki Disease?
Acute: five days of high fever, BL conjunctivitis, erythematous pharynx, strawberry tongue, truncal rash, desquamating palms and soles, UL and painful cervical lymphadenopathy
Subacute: Thrombocytopenia, elevated ESR, coronary artery aneurysms
Chronic: last until ESR returns to baseline and the aneurysm is in the clear
What is the treatment for Kawasaki Disease?
Aspirin and IVIG
