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Flashcards in CARCINOGENICITY Deck (11):
1

list the conditions/dz caused by Ochratoxin A (OTA)

  • balkan endermic nephropathy
  • urinary tract tumors(UTT)

2

what is karyomegally

  • end stage renal failure
  • it means increase in size og nuclues of tissue cells

3

cs of karyomegally 

  • urinary loss of proteins
  • glucose,
  • GGT
  • serum:
    • decreaed cholesterole,
    • protein
  • progressive tubulo-interstitial nephropathy
  • tubular atrophy
  • periglobular atrophy
  • cortical cysts

4

pathological marker in OTA toxicity

karyomegally in proximal tubular cells

5

acute toxicity testing

  • single dose of LD50

6

90 days rodent assay determines.................

NOAEL

7

NOAEL PROVIDES THE BASIS FOR ................

ADI

8

9

WHAT IS THE USE OF ADI

  • PROVIDES THE BASIS FOR ACCEPTABLE RESIDURE LEVELS IN FOOD,
    • MRL (VMP)= IN EDIBLE TISSUE OF ANIMALS (MILK,TISSUE)
    • ML=MAXIMUM (PERMISSIBLE) LEVELS→CONTAMINANTS→ALL FOOD

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