Cardiac Flashcards

(81 cards)

1
Q

Preload

A

The amount of blood returning to the RIGHT side of the heart and the muscle stretch that the volume causes. ANP is released when we have this stretch

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2
Q

Afterload

A

The pressure in the aorta and peripheral arteries that the left ventricle has to pump against to get blood out

This pressure is referred to as resistance

With hypertension there is even more resistance to pump against thats why HTN can eventually lead to HF and pulmonary edema, because high afterload decreases cardiac output and decreases the forward flow, in addition to wearing out your heart.

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3
Q

Stroke volume

A

The volume of blood pumped out of the ventricles with each beat

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4
Q

Cardiac Output

A

Tissue perfusion is dependent on an adequate cardiac output. Cardiac output changes according to the body’s needs

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5
Q

Factors that affect Cardiac Output

A

Heart rate and arrhythmia’s such as A.fib, Tachycardia and Bradycardia.

Blood Loss = Less volume, Less pressure (less perfusion). More volume, more pressure.

Ineffective contractility due to MI, cardiac muscle disease , medication

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6
Q

Angiotensin- converting Enzyme (ACE) Inhibitors

A
Captopril (Capoten),
Enalapril (Vasotec),
Lisinopril (Zestril, Prinivil),
Moexipril (Univasc),
Ramipril (Altace)

Commonly used for Heart failure, HTN and MI

PO/IV
1-2 hours/ 15-30 minutes

Interactions: Hyperkalemia can result if takein in combination with potassium sparing diuretics or eating salt substances

MoA:Suppress the Renin Angiotensin System (RAS). Prevents the conversion of Angiotensin I to Angiotensin II. This results in arterial dilation (decreasing the afterload) and increased stroke volume. ACE inhibitors block aldosterone so the client loses sodium and water and retains potassium. ACE inhibitors improve lung function by increasing alveolar-capillaries membrane diffusing capacity and pulmonary function in patients with HF.

Advantages: Effective in treating heart failure

Disadvantages: African Americans and older adults do not respond to ACE inhibitors with the desired reduction in blood pressure without the addition of a diuretic

Side effects: Dizziness
Hyperkalemia
Hypermagnesemia
Fatigue
Headache
Dry, nonproductive cough

Adverse effects: Angioedema, Orthostatic hypotension

Interventions:
Monitor BP and HR.
Monitor potassium and magnesium levels.
Initiate safety precautions.

Education:
Rise slowly from lying or sitting to standing position.
Safety precautions.
Can be administered with food (EXCEPT: Moexipril)
Do not use salt substitutes with potassium.

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7
Q

Angiotensin 2 Receptor Blockers (ARBS) - Decrease After load

A

Losartan (Cozaar),
Olmesartan (Benicar),
Valsartan (Diovan)

Common Uses: HTN and HF

PO/ 2 Hours

Intercations: MAOIs, alcohol,
diuretics may increase
hypotensive effects.
ACE inhibitors and
ASA may increase
hyperkalemia and renal
dysfunction

MoA: Prevent the release of aldosterone. They act on the renin-angiotensin system (RAS). ARBS block angiotensin II from the
angiotensin I receptors found in tissue. Potent vasodilator. Decreases peripheral resistance. Decrease the workload of the heart by decreasing afterload. This will increase cardiac output and keep blood moving forward out of the heart.

Advantages: Do not cause the constant, irritating dry
cough that ACE inhibitors do.

Disadvantages:Less effective for treating hypertension in
African-American clients.

Side Effects: Headache
Dizziness
Drowsiness
GI complaints
Fatigue
Adverse Effects:
Orthostatic hypotension
Hypoglycemia
Hyperkalemia
Renal dysfunction
Angioedema

Interventions: Monitor BP and Heart rate, AST, ALT, BUN and creatinine.

Education:
Rise slowly from lying and sitting position to standing position.
Safety precautions.
Can be taken on empty or full stomach.
Do not use salt substitutes.
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8
Q

Antianginal/ Nitrates

A

Nitroglycerin - Decreases the preload and Afterload

Common use: Angina, MU and pulmonary Edema

Contraindications: 
Pre-existing Hypertension
Head trauma
Increased ICP
Pericardial tamponade
SL - 1 every 5 min. up to 3 doses. (1 - 3 minutes)
Tablet - 20 - 30 mins
Spray
Ointment: 20 - 60 mins
Transdermal- 30 - 60 mins

Interactions: Enhance hypotensive effects: Beta blockers, Calcium channel blockers, Vasodilators, Alcohol, Erectile dysfunction meds
May antagonize effects of
Heparin: IV nitroglycerin

MoA: Acts directly on the smooth muscle of venous and arterial blood vessels, causing relaxation and dilation. Dilates coronary arteries. Sublingual administration rapidly absorbs into the internal jugular vein and right atrium. IV nitroglycerin vasodilates the client to decrease afterload which increases cardiac output, so that more blood can be pumped forward

Advantages:
Decreases preload, afterload, and workload of the heart
Increases blood flow to heart muscle
Reduces myocardial oxygen demand

Side Effects: 
Headache Faintness/Syncope
Nausea/vomiting Dizziness
Flushing Palpitations
Diaphoresis Tolerance
Contact dermatitis with topical
ADVERSE EFFECTS:
Hypotension
Reflex Tachycardia
Paradoxical Bradycardia
Circulatory Collapse
Interventions: 
Monitor Blood pressure.
Do not leave client until BP stabilizes.
Assess cardiac output.
Evaluate pain relief.
Safety precautions.
Maintain adequate hydration.
IV: Use a pump; hold for systolic BP < 100

Education:
Activate EMS if pain unrelieved after taking 1 tab SL or spray.
Do not swallow SL nitro.
Keep in dark, glass bottle.
Do not mix medications in bottle with nitroglycerin.
Do not open bottle frequently.
Keep dry and cool.
May or may not burn or fizz in mouth.
Renew every 3-5 months; 2 years of spray.

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9
Q

Antidysrhythmic Class 3 /Amiodarone

A
Commonly used when V-fib and pulseless V-tach
are resistant to a
vasopressor and
defibrillation.
Fast arrhythmias.
Contraindications:
Cardiogenic shock
2nd degree heart block
3rd degree heart block
Iodine allergy

IV/PO/Rapid

Interactions: MAOIs-hyperpyretic crisis, seizures.

MoA: Prolongs duration of action potential and refractory period to decrease heart rate. Decreases peripheral vascular resistance and
increases PR and QT intervals. First antiarrhythmic of choice.

Advantages:
Very little negative inotropic activity making it advantageous for use in clients with heart failure.

Disadvantages:
Potentially serious side effects requiring careful monitoring. Has lots of iodine in it - can affect thyroid function.

Side Effects: 
Photophobia
Weakness
Skin discoloration
Tremors
Impaired thinking/reactions
Adverse Effects:
Hypotension Bradycardia
Difficulty breathing Wheezing
Chest pain Light-headed
Vision loss Jaundice

Interventions:
IV: Continuous ECG monitoring and BP monitoring
PO: Assess BP lying, standing. If systolic BP drops 20 mmHg, hold.
Monitor Hepatic studies: AST, ALT, bilirubin.

Education:
Do not skip a dose or discontinue abruptly.
Do not take with grapefruit juice.
Use sunscreen or stay out of sun to prevent burns.
Dark glasses may be needed for photophobia.

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10
Q

Lidocaine

A

Common Uses:
Frequent PVCs
Ventricular tachycardia
Alternative antiarrhythmic agent to amiodarone in the treatment of cardiac
arrest secondary to VF or pulseless VT resistant to CPR, cardioversion (after 2 to 3 shocks) and a vasopressor (epinephrine)

Contraindications: Adam-Stokes Syndrome and Heart block

IV/ 45 to 90 seconds

Interactions:
Lidocaine toxicity
– cimetidine, beta
blockers. Increase
lidocaine effects – barbiturates, ciprofloxacin

MoA:Decreases irritability of the heart muscle. Increases electrical stimulation threshold of ventricles, which stabilizes cardiac
membrane and decreases automaticity.

Side Effects: 
Headache
Dizziness
Drowsiness
Blurred vision
Phlebitis
Adverse:
Heart block Seizures
CNS depression
Respiratory depression
Malignant hyperthermia
Lidocaine toxicity

Interventions:
Administer IVP at a rate of 25-50 mg/minute. Monitor lidocaine blood levels.
Continuous ECG monitoring. Observe for prolonged PR interval and QRS
complex.
Have resuscitative equipment readily available.
Watch for malignant hyperthermia: tachypnea, tachycardia, changes in BP,
increased temperature.
Monitor for signs of toxicity (hearing impairment, muscle twitching, confusion,
seizures).

Education:
About the use of lidocaine.
Report signs of toxicity (hearing impairment,
muscle twitching, confusion)

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11
Q

Lidocaine Toxicity

A

Lidocaine toxicity (and all local anesthetic toxicity) can cause circumoral numbness, facial tingling, restlessness, vertigo, tinnitus, slurred speech, and tonic-clonic seizures. Local anesthetics are actually CNS depressants, thus tonic-clonic seizures are thought to be caused by depression of inhibitory pathways.

Circumoral and/or tongue numbness.
Metallic taste.
Lightheadedness.
Dizziness.
Visual and auditory disturbances (difficulty focusing and tinnitus)
Disorientation.
Drowsiness.
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12
Q

Beta blockers

A
RATE CONTROL 
Atenolol (Tenormin)
Metoprolol
(Lopressor)
Propranolol (Inderal)
Carvedilol (Coreg)

Commonly used for HTN, Angina, dysrhythimias, MI, migraines, Tachycardia due to stage fright

Contraindications:
2nd and 3rd degree heart Block, Cardiogenic Shock, Hypotension, AHF, Sinus Bradycardia

PO/IV

Interactions: Digitalis worsens bradycardia.
Other antihypertensives and
alcohol worsen HTN.
NSAIDS, Licorice, ma-haung,
ephedra decrease effect
of beta blockers causing
hypertension.
Black cohosh, Hawthorn,
Parsley, Goldenseal increase
hypotensive effect.

MoA: Blocks beta receptor cells (catecholamines) to decrease vascular resistance, decrease BP, decrease HR, decrease myocardial
contractility, decrease workload of the heart, decrease cardiac output, decrease renin release.

Advantages: Well tolerated in low doses

Side Effects: 
Blurred vision Mental changes
Nasal stuffiness Photosensitivity
Sexual dysfunction Fatigue
Weakness Dizziness
Lethargy Nausea/ Vomiting
Diarrhea Headache
Depression Insomnia  
Adverse Effects: 
Bradycardia
Hypotension
2nd &amp; 3rd degree Heart block
Thrombocytopenia
Bronchospasm
Wheezing

Interventions:
Monitor for increased BUN, Creatinine, AST, LDH, Glucose.
Do not discontinue abruptly: Rebound HTN, angina, dysrhythmias, MI
can result.
Monitor BP & pulse.
Hold for HR < 60 / min.

Education:
Teach how to take radial pulse and BP.
Rise slowly to prevent postural hypotension.
May cause sexual dysfunction.
Report constipation: Eat foods high in fiber

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13
Q

Calcium Channel Blockers

A
RATE CONTROL 
Amlodipine
(Norvasc), Diltiazem
(Cardizem),
Ranolazine (Ranexa)

Common Uses: Angina, HTN, Dysrhythmias, Migraines and Raynauds Disease

Contraindications: Heart Block, Hypotension, Severe Heart Failure

PO (10 - 30 mins )/ IV (3mins)

Interactions:
Increased levels of digitalis,
theophylline.
Decreased effects of lithium.
Increased hypotensive
effects with grapefruit juice

MoA: Blocks the calcium channel in the vascular smooth muscle cells. This causes vasodilation of the arterial system to decrease arterial resistance and decrease blood pressure. This decreases afterload, which decreases the workload of the heart. These medications dilate the coronary arteries so more oxygen reaches the heart muscle

Advantages: Decreases afterload and increases
oxygen to the heart muscle.
Decreases BP better in African
Americans than drugs in other categories
Disadvantages: Need to reduce dose with known liver disease

Side Effects: 
GI upset
 Ankle edema
Dermatitis 
Flushing
Headache 
Dizziness
Adverse Effects: 
Bradycardia
Reflex Tachycardia
Heart Block
Hypotension
Dyspnea
Wheezing

Interventions:
Taper dose: Do not discontinue abruptly.
Monitor BP, HR – Notify PHCP for HR < 50 or Systolic BP < 90.
Monitor for increased AST, ALT, Alk phosphatase, BUN, Creatinine, and cholesterol.

Education: Do not stop taking abruptly. Rise slowly.
Increase fluids and fiber to counteract constipation.
Teach how to take pulse and BP.
Avoid hazardous activities until dizziness is no longer a
problem.
Avoid grapefruit products.
Report chest pain, palpitations, irregular heart rate, swelling of extremities, tremor

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14
Q

Digoxin

A

RATE CONTROL

Used in heart failure and atrial fibrillation

Contraindicated in Ventricular dysrhythmias and Heart blocks

PO/IV

Interactions: Loop diuretics can cause hypokalemia and dig toxicity.
Ginseng may elevate digoxin
levels
St John’s wort decreases
absorption of digoxin.
Decrease dig absorption with
antacids. 

MoA: Promotes increased force of cardiac contraction, cardiac output, and tissue perfusion. Decreases ventricular rate. So heart
contraction is stronger, heart rate slows down. This allows more blood to be ejected out of the ventricles in a forward
direction

DIGOXIN TOXICITY IS VERY BAD - elderly are prone to same

Side Effects: Headache and Dizziness

Adverse Effects:
Dig toxicity: anorexia, n/v, weird arrhythmias,
vision changes.
Heart block

Interventions:
Monitor Digoxin level (Normal 0.5-2 ng/mL)
Monitor potassium (Low K+ can increase risk for dig toxicity)
Monitor apical pulse. Hold dig for HR < 60 bpm in adults.
Administer IV dose slowly over 5 minutes.
Monitor for signs of dig toxicity: anorexia, nausea/vomiting, weird
arrhythmias, vision changes.
Antidote: Digoxin immune Fab (Digibind)

Education: Teach client how to take pulse, Signs of Dig Toxicity

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15
Q

Norepinephrine

A

Used in Shock and acute hypotension

Contraindicated in Tachy dsyrhythmias, Pheochromocytoma, Hypovolemia

IV

Interactions: Increase pressor effect with tricyclics, MAOIs.
Decreased norepinephrine action with alpha blockers

MoA: Potent vasoconstrictor action (alpha-adrenergic effect). It is used in shock states, often when drugs such as dopamine and
dobutamine have failed to produce adequate blood pressure. Causes increased contractility and heart rate by acting on beta receptors of the heart.

Disadvantages:
Has potential to impair cardiac performance and decrease organ and tissue perfusion.

Side Effects: 
Headache Anxiety
Dizziness Insomnia
Tremor Palpitations
Nausea/vomiting
Adverse Effects: 
Myocardial ischemia/Dysrhythmias
Impaired organ perfusion
Tissue necrosis with extravasation.
Cerebral hemorrhage
Anaphylaxis

Interventions:
Correct hypovolemia prior to use.
Continuous cardiac monitoring.
Precise blood pressure monitoring and HR every 2-3 min.
Taper drug slowly as abrupt discontinuation can result in severe hypotension.
Monitor IV site for extravasation frequently. If extravasation occurs,
inject with phentolamine.
I&O

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16
Q

Direct Acting Vasodilators

A

DECREASE AFTERLOAD

Hydralazine
(Apresoline)
Nitroprusside
(Nipride)

Common Uses: Hypertension
Hypertensive crisis
Severe heart failure
Acute MI with
hypertension and
persistent chest pain and
/or left ventricular failure

Contraindications: Systemic Lupus, Severe Tachycardia with heart failure

PO/IV
Interactions: Increase antihypertensive
effects: ACE inhibitors,
vasodilators, diuretics,
alcohol, MAOIs, tricyclic
antidepressants,
hawthorn.

MoA: Relaxes smooth muscles of the blood vessels, mainly arteries, causing vasodilation. Promotes an increase in blood flow to the
brain and kidneys

Advantages: Nitroprusside is a potent vasodilator that
rapidly decreases BP in hypertensive crisis.

Disadvantages: Adverse effects eliminate use of these drugs as drug of choice

Side Effects: Headache
Dizziness
Hyperglycemia
Sodium and water retention
Peripheral edema

Adverse Effects:
Reflex tachycardia
Hypotension
Rebound hypertension

Interventions:
Monitor vital signs, I&O, glucose.
Daily weight
Nitroprusside: Monitor BP frequently with continuous cardiac monitoring.

Education:
Purpose of medication
Safety precautions
Move slowly from lying or sitting to standing position.

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17
Q

Hypertensive Crisis

A

A hypertensive crisis is a severe increase in blood pressure that can lead to a stroke. Extremely high blood pressure — a top number (systolic pressure) of 180 millimeters of mercury (mm Hg) or higher or a bottom number (diastolic pressure) of 120 mm Hg or higher — can damage blood vessels.

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18
Q

Direct Vasodilators/ Nesiritide

A

Acute Treatment of heart failure in clients with dyspnea at rest or minimal activity

Contraindications: Valvular Stenosis, Cardiomyopathy, Pericardial tamponade

IV/ 15 mins

MoA: A B-type natriuretic peptide, which is normally produced by the ventricular myocardium. It relaxes and dilates blood vessels,
lowering blood pressure.

Advantages: Useful for clients decompensating from acute heart failure

Disadvantages: For short term IV use only: up to 48 hours. Nephrotoxic.

Side Effects:
Headache
Dizziness
Nausea/Vomiting

Adverse Effects: 
Hypotension
Irregular HR
Chest pain
Fever
Unusual weakness
Interventions: 
Monitor creatinine level
Monitor vital signs, hourly urine output
ECG monitoring
Daily weight
Monitor for allergic reaction (rash, pruritus, laryngeal edema, wheezing)
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19
Q

Oxygen

A
Common use: 
Hypoxemia
Severe anemia
Carbon monoxide
poisoning
Shock
Heart failure

Route: NC Face Mask, Non rebreather, ET, CPAP/biPAP

MoA:
Inadequate oxygenation produces hypoxemia and significant physiologic changes to all body systems, therefor oxygen is a
first-line drug for all emergency situations. Oxygen also acts as a potent pulmonary vasodilator and is beneficial for clients in
heart failure.

Disadvantage: An FiO2 above 50% for a prolonged
period can lead to oxygen toxicity and detrimental effects to the pulmonary
system

Side Effects: Dry or bloody nose
Skin irritation
Morning headaches
Fatigue
ET: mucus plugs, tracheal injury, infection, ET
misplacement

Adverse Effects: Oxygen Toxicity

Interventions:
Make sure that the client’s airway and breathing are adequate to
promote optimal oxygenation and ventilation.
Monitor pulse oximetry. Optimal oxygen saturation is at or above
94%.
Notify primary healthcare provider for oxygen saturation less than
90%.

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20
Q

Dobutamine

A

SHOCK

Contraindications: Aortic Stenosis

IV (1 -2 mins)

Interactions: Increased pressor effect and dysrhythmias with tricyclics, MAOIs.

MoA: The beta1 effects enhance the force of myocardial contraction (positive inotropic effect) and increasing heart rate (positive
chronotropic effect). The beta 2 effects produce mild vasodilation

Advantages: BP is elevated only through the increase in cardiac output

Side Effects: 
Headache Nausea
Tremors Anxiety
Dizziness Fatigue
Palpitations
Adverse Effects: 
Myocardial ischemia
Tachycardia Dysrhythmias
Hypotension Hypertension
Hypokalemia 

Interventions:
Correct hypovolemia prior to use.
Usual IV dose is 2-20 mcg/kg/min. Administer via electronic infusion
pump for precision. Taper gradually to avoid clinical deterioration.
Continuous cardiac and blood pressure monitoring.
I&O
Monitor vital signs
Assess for signs of myocardial ischemia.
Continuous ECG monitoring

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21
Q

Epinephrine

A

Used for Cardiac arrest, Asystole, V fib, Acute asthmatic attacks , Anaphylaxis

Contraindications: Closed Angle Galucoma

IVP / Rapid
Do not use with
MAOIs or tricyclics –
hypertensive crisis may
occur.

MoA: Vasoconstriction effects: epinephrine binds directly to alpha-1 adrenergic receptors of the blood vessels (arteries and veins)
causing direct vasoconstriction, thus, improving perfusion pressure to the brain and heart.
Cardiac Output: epinephrine also binds to beta-1-adrenergic receptors of the heart. This indirectly improves cardiac output by
increasing heart rate, heart muscle contractility, and conductivity through the AV node

Used to simulate the heart muscle

Side Effects:
Tremors Palpitations
Headache Hypertension
Dizziness Nausea/Vomiting

Adverse effects:
Cerebral hemorrhage
bronchospasms

Interventions:
Elevate extremity for 10-20 seconds to facilitate drug delivery to the
central circulation.
Auscultate lungs
Monitor pulse, BP, respirations.
Continuous cardiac monitoring
Do not administer in same IV site as Sodium Bicarbonate

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22
Q

Loop Diuretics

A

Furosemide (Lasix)
Bumetanide (Bumex)
Torsemide (Demadex)

Heart Failure
Renal Failure
Hepatic disease
Hypertension
Hypercalcemia (increases
renal excretion of calcium)
FVE
Contraindications: 
Hypovolemia
Anuria
Severe electrolyte
imbalances
Hepatic coma
PO/IV
Interactions: Increase ototoxicity
with aminoglycosides.
Increase bleeding
with anticoagulants.
Increase digoxin
toxicity with digoxin
and hypokalemia

MoA: Causes diuresis, but also will cause vasodilation to trap blood out in the arms and legs which reduces preload and afterload.

Advantages: Rapidly removes fluid to help clients in acute
heart failure or pulmonary edema.

Disadvantages: Potassium-wasting Should not be used if a thiazide could alleviate body fluid excess

Side Effects: 
Nausea Diarrhea
Vertigo Constipation
Weakness Headache
Electrolyte imbalances
Abdominal cramping
Constipation
Adverse Effects: 
Severe dehydration 
Gout
Marked hypotension
Hyperglycemia
Hearing loss
Renal failure
Thrombocytopenia 

Interventions:
Assess vital signs, UOP, electrolytes.
Daily weight
Monitor potassium levels. Observe for signs of hypokalemia.
Monitor digoxin levels if taking digoxin.
Administer IV dose over 1-2 minutes to prevent hypotension and ototoxicity

Education:
Advise to take in the morning and not in the evening to
prevent sleep disturbance and nocturia.
Rise slowly from lying or sitting to standing.
Take with food to avoid nausea.
Eat foods high in potassium.

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23
Q

Pathophysiology of decrease Cardiac Output

A

Lack of proper perfusion.

Brain: Decreased LOC
Heart: Increased Pain
Lungs: Sound Wet and SOB
Skin: Cool and Clammy
Kidneys: UO goes DOWN
Pulses: Decreased/ Thready 

Arrthymias are no big deal until they affect CO
Pulseless V TACH, V FIB and A-systole

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24
Q

Coronary Artery Disease

A

Most common type of Cardiovascular disease. Includes Chronic stable angina and Acute Coronary Syndrome.

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25
Chronic Stable Angina: Patho and treatment
Intermittent decreased blood flow to heart that leads to ischemia. This ischemia can lead to temporary pain/pressure in the chest because of the low perfusion due to exertion. Relieved by Rest and nitro Treatment: Nitro Beta blockers ( for prevention of Angina) - Decreases contractility, decreases CO thus decreasing workload of the heart. Calcium Channel Blockers ( prevention of angina) - decreases the afterload through vasodilation and increases oxygen to the heart muscle ASA: Antiplatelet.
26
Chronic Angina: Client Education and Teaching
``` Rest frequently Avoid Overeating Avoid excess caffeine of any drugs that increase HR Wait 2 hours after eating to excercise Dress warmly in cold weather ( any temperature extreme can precipitate an attack) Take Nitro prophylactically Smoking Cessation Lose Weight Avoid isometric exercise Reduce Stress ``` DO EVERYTHING YOU CAN TO DECREASE THE WORKLOAD OF THE HEART
27
Cardiac Catheterization: Pre and Post Procedure
Pre procedure: Ask if allergic to Iodine/contrast or Shellfish CHECK THAT KIDNEY FUNCTION because dye is excreted through the kidneys Acetylcytsteine is given pre- procedure if client has kidney problems. It protects the kidneys . HOT SHOT Palpitations are normal Post Procedure Monitor Vital Signs Watch the puncture site for bleeding and Hematoma formation Assess Pulselessness, Pallor, Pain, Paresthesia and Paralysis, extremely distal from puncture site, as well as circulation and vascular check Bed rest, Flat, Extremely straight for 4 -6 horus Major complication is hemorrhage report Pain ASAP If the client is on metformin, you must hold this med for 48 hours post procedure. We are worried about blood sugar impacting the kidneys.
28
Acute Coronary Syndrome ( MI, Unstable Angina) : Patho and Signs and Symptoms
Decreased Blood flow to the myocardium leads to both iscehmia and necrosis SIgns and Symptoms : Pain that is crushing, with pressure radiating to left arm and left jaw, N/V or pain between the shoulder blades Cold/clammy/ drop in BP and pulse Cardiac Output drops ECG changes Vomiting ( stimulates the vagus nerve which lowers the heart rate) PVC's because of hypoxia in the heart In women, they usually present with GI signs and symptoms, epigastric discomfort or pain between shoulders, an aching jaw or choking sensation. In the elderly and Diabetic, there will be behavioural changes, less or no pain, fainting and SHORTNESS OF BREATH
29
CPK-MB
Cardiac specific isoenzyme Increased with damage to cardiac cells Elevates within 3 - 6 hours and peaks in 12 to 24 hours
30
Troponin
Cardiac Biomarker with high specificity to myocardial damage Elevates within 3 to 4 hours and remains high for up to 3 weeks
31
Myoglobin
Increased within 1 hour and peaks in 12 hours. Negative results are a good thing
32
Major Arrhythmias
Pulseless V. Tach, V.Fib and Asystole put the client at risk for sudden death Priority treatment V. Fib is DEFIB If the first shock doesn't work and the client remains in V-Fib, what is the first vasopressor we give? Epinephrine Amiordarone is an anti-arrhythmic and is used when V.Fib and pulseless VT are resistant to treatment and also for fast arrhythmias ( not a vasopressor)
33
If the first shock doesn't work and the client remains in V-Fib, what is the first vasopressor we give?
Epinephrine
34
What anti-arrhythmic drugs are commonly given to prevent a second episode of V-Fib?
Amiodarone or Lidocaine. Hypotension is an important side effect of amiodarone so watch BP as it can lead to further arrthymias because of decreased perfusion.
35
What are the first signs of lidocaine toxicity?
any CNS changes
36
Treatment for ACS
Oxygen, Aspirin, Nitro and Morphine Head up position ( decreases workload on the heart and increases effectiveness/CO) Thrombolytics Dissolves the clot that is blocking blood flow to the heart muscle --> decreases the size of the infarction Medications: alteplase, tenecteplasem reteplase and streptokinase Should be administered within 6 to 8 hours TIME IS BRAIN ( within three hours for a stroke client) Major complication: bleeding Obtain a good health/bleeding histroy ABSOLUTE CONTRAINDICATIONS: Intracranial neoplasm, intracranial bleed, suspected aortic dissection or internal bleeding, reent surgery, stroke, pregnant and ulcers During and after admin, we take bleeding precautions Follow-up therapy: Anti platelets are another important factor of thrombolytic therapy
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Bleeding precautions
For anticoagulants, antithrombotics and Tylenol overdose / liver disease or damage Watch for bleeding gums, hematuria and black stools. use electric razor, soft toothbrush, no IM's. Draw blood when starting IV's, decrease the number of puncture sites. NO ABG's
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PCI (Percutaneous Coronary Intervention)
Includes all interventions such as angioplasty and stents Major complication of an angioplasty is an MI. The patient may bleed from the cath site or they could reocclude; If there is chest pain after the procedure, They must go to the cath lab to fix this as they are reoccluding. Antiplatelets are on BOARD : ASA, Clopidogrel, Abciximab and Eptifibatide ( last two given to clients who have been stented to keep artery open and those waiting to go to the cath lab)
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Coronary Artery Bypass Graft ( CABG)
Can be scheduled or emergency procedure Used with multiple vessel disease or left main coronary artery occlusion The LEFT main coronary artery supplies the entire left ventricle. Occlusion = death.
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CARDIAC REHAB
Smoking cessation Stepped care plan Diet changes : less fat, sugar and cholesterol No isometric exercises- increases the workload of the heart No Valsalva Maneouver No straining, suppositorys or docusate ( Use Stool softener) Sex can be resumed when client is able to walk up a flight of stairs - 1 week to 10 days. Safest time is the morning, when the client is well rested The best excercise is walking. S/s of heart failure (Weight gain, Ankle Edema, SOB and Confusion) - pt is at increased risk after MI
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Heart Failure Causes + Types
HF is a complication that can result from problems such as cardiomyopathy, valvular heart disease, endo-carditis, acute MI and HTN ``` Types: Left Sided: blood going back in towards the lungs Pulmonary congestion Dyspnea Cough Blood tinged frothy sputum Restlessness Tachycardia S-3 Orthopnea Nocturnal dyspnea ``` Right Sided Failure: Blood going backward into body systems. Can be caused by pulmonary embolism - hypoxia and pulmonary HTN increase the workload on the right side of the heart leading the R HF. COPD in the end stages is always hypoxic because the right side if failing from pulmonary edema/HTN ``` Distended Neck veins Edema Enlarged Organs Weight gain Ascites FVE ```
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Heart Failure Diagnosis
B-type natriuretic peptide Secreted by ventricular tissues in the heart when ventricular volume and pressures in the heart are increased Sensitive indicator Can be positive for heart failure when the CXR does not indicate a problem If pt is on nesiritide, turn it off 2 hours prior to drawing a BNP CXR Enlarged heart, pulmonary infiltrates (fluid) at lung bases Echocardiogram: Looks at the pumping action or ejection fraction of the heart. An ECG can also give you info on backflow and valve disease
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Treatment of HF - ACE, ARBS and Digoxin + Nursing considerations
ACE inhibitors DOC for HF results in arterial dilation and increased stroke volume Monitor for hyperkalemia because it blocks aldosterone, which usually excretes potassium ARBS Decrease arterial resistance and cause decreased BP Monitor for hyperkalemia because it blocks aldosterone, which usually excretes potassium Both these drugs decreases the workload on the heart by prevent vasoconstriction (decreasing the afterload) This will increase the cardiac output and keep blood moving forward out of the heart. Digoxin Monitor for toxicity, especially in the elderly. Used when client is in sinus rhythm or a.fib and has accompanying chronic HF Often given in combination with ACE inhibitor, ARBS, Beta blockers or diuretics Contractions are stronger, HR decreases Increasing Cardiac Output and Kidney perfusion Nursing considerations Normal dig level = 0.5 - 2 ng/ml You know dig is working because CO goes up Before giving, take apical pulse for one minute monitor electrolytes - Hypokalemia + digoxin = toxicity
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Digoxin Toxicity
Early signs: Anorexia, nausea, vomiting Late: weird arrhythmias and vision changes Any electrolyte imbalance can promote toxicity
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Treatment of HF - Diuretics
Diuresis is a GOOD thing for this client because they can't handle the fluid. Diuretics will decrease the preload Give in the morning, because client will be peeing all day. At night, this will increase their risk for falls.
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Treatment of HF - non-pharmacological interventions
Low sodium diet Decreases fluid retention and helps decrease the preload Watch salt substitutes as they can contain excessive potassium Elevate head of the bed Weigh Daily and report gain of 4.4 lb ( 1-2 kg) Fluid retention - think heart problems 1st Report signs and symptoms of recurring failure
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Pacemakers
Your natural pacemaker is the SA node - it sends out impulses that make the heart beat If your heart rate drops to 60 or below, cardiac output can decrease, thus decreasing perfusion to organs such as brain and showing decreased CO symptoms Pace makers are used for symptomatic bradycardia They can be temporary ( invasive or non-invasive) or permanent. Most are on demand but you can also see fixed. Always worry if it drops below set rate Any pace maker will maintain a certain minimal heart tate depending on the set rate A demand pacemaker kicks in only when the client needs it OK for rate to increase, but never decrease
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Post procedure care for permanent pace -makers
Monitor the incision Most common complication is electrode displacement Monitor ECG for changes Immobilize arm - avoid extension Assisted passive range of motion to prevent frozen shoulder Keep client from raising the arm higher than shoulder height pt teaching : Check pulse daily - ID card or bracelet - avoid electromagnetic fields and MRI's Signs and symptoms of Malfunction Loss of Capture - no contraction following stimuli ( can affect CO) Failure to sense - pacemaker fires at inappropriate times LOOK FOR DECREASED CO S/S
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Pulmonary Edema: Risks, Patho and S/S
Who is at risk? Any one receiving IV fluids very quickly, The very young and very old and any person who has a history of heart or kidney disease Fluid is backed up into the lungs, the heart is unable to move the volume forward. Usually occurs at night when the client goes to bed. ``` Signs/Symptoms Sudden Onset Breathless Restless/anxious Productive cough ( pink frothy sputum) ```
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Pulmonary Edema Treatment
Priority nursing action is to administer high flow oxygen. Monitor SPO2 and titrate to keep above 90% Meds: Furosemide : causes diuresis and vasodilation which traps more blood out in the arms and legs and reduces preload 40mg IVP over 1-2 minutes to prevent otoxicity Bumetanide: can be given IV push or as a continuous IV infusion to provide rapid fluid removal 1-2mg IVP over 1-2 minutes Nitro: Vasodilation to decrease afterload = increased CO because the heart is pumping against less pressure and more blood can move forward Morphine: 2mg IV push for vasodilation to decrease preload and afterload Nesiritide: IV infusion - short term therapy, not for more than 48 hours, vasodilates veins and arteries and has a diuretic effect Upright Position; Legs down. Improves CO because gravity helps pumping. promotes pooling of blood in lower extremities
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Cardiac Tamponade: Patho and Signs and Symptoms
Blood, Fluids or exudates hae leaked intp the pericardial sac resulting in compression of the heart. This can occur in an MVA, Right ventricular biopsy, an MI, pericarditis or hemorrhage post CABG ``` Decreased CO Increased CVP because of the pressure BP dropping because CO bottoming out Heart sounds will be muffled or distant Neck veins will be distended Pressures in all four chambers are the same Narrowed pulse pressure Shock Paradoxical pulses Dypsnea Increased pulse ```
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Cardiac Tamponade : Treatment
Pericadiocentesis to remove fluid from around the heart | Surgery
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Arterial disorders
If you have atherosclerosis in one place, you have it everywhere It is a medical emergency if you have an acute arterial occlusion Client will report numbness and pain. Extremity will be cold. No palpable pulses, More symptomatic in lower extremities Intermittent claudication - hallmark sign for arterial problems coldness numbness, decreased peripheral pulses, atrophy, bruit, thick and brittle nails and ulcerations Pain at rest means SEVER obstruction Treatment: Since arterial blood is having problems getting to the tissue, if you elevate the extremity, the pain would increase. WE DANGLE ARTERIES. Usually treated with angioplasty or endarterectomy
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Infective endocarditis
S/s - Fever, malaise, murmur, weight loss, splinter hemorrhage and Oslar nodes Splinter hemorrhages are tiny clots that run vertically under the finger nails. Oslers Nodes are painful subQ lesions thaat occur in the palms, soles and pads. Risk factos include: Mechanical heart valve replacement, IV drug use, dental procedures, rheumatic fever and immunosuppression
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Paradoxal Pulse
Pulse stops when client takes a deep breath
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Thromboangittis obliterans
Characterized by inflammation and thrombosis of the vessels of the hands and feet. It is strongly associated with smoking. Usually treated with vasodilators and sometimes bypass surgery. Ulceration is a common complication.
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Corrigan's Pulse
A pulse that is forceful and then suddenly collapses. It is usually found in patients with aortic regurgitation, a condition caused by a leaky aortic valve. The left ventricle of the heart ejects blood under high pressure into the aorta.
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Risk Factors for Primary HTN
High salt and fat intake, obesity, stress, alcohol consumption, inactivity, caffeine and vitamin D deficiency Primary HTN does not have any identifiable causes
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Mitral stenosis
is a narrowing of the mitral valve opening that blocks (obstructs) blood flow from the left atrium to the left ventricle. Mitral stenosis usually results from rheumatic fever, but infants can be born with the condition. Mitral stenosis does not cause symptoms unless it is severe. Does not cause syncope
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Aortic stenosis
Narrowing of the aortic valve. This causes reduced cardiac output and increased left ventricle pressure. Syncope is the hallmark
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Aortic Regurgitation
``` also known as aortic regurgitation (AR), is the leaking of the aortic valve of the heart that causes blood to flow in the reverse direction during ventricular diastole, from the aorta into the left ventricle. Does not cause syncope. Symptoms: chest pain or tightness that increases with exercise and subsides when you're at rest. fatigue. heart palpitations. shortness of breath. difficulty breathing when lying down. weakness. fainting. swollen ankles and feet. ```
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Anticoagulants - Heparin sodium, warfarin (Coumadin), Enoxaparin (Lovenox), dabigatran etexilate (Pradaxa)
``` DVT Pulmonary embolisms Thromboembolic complications Prevention of clot formation Dialysis Open heart surgery DIC Atrial fibrillation with embolization ``` Contraindicated if bleeding SUBQ/IV Interactions: Increase heparin action with oral anticoagulants, salicylates, NSAIDS, penicillin, SSRIs. Decrease heparin action with digoxin, tetracyclines, antihistamines, cardiac glycosides, nicotine, nitroglycerin. Increase bleeding risk with garlic, ginger, ginkgo, green tea. MoA: Prevents conversion of fibrinogen to fibrin and prothrombin to thrombin by enhancing inhibitory effects of antithrombin III. Disadvantages: Does not dissolve clots that are already present ``` Side Effects: Injection site reactions Fever Chills Headache Rash ``` ``` Adverse Effects: Hemorrhage Hypotension Thrombocytopenia Anaphylaxis ``` Interventions: Monitor aPTT (Activated Partial Thromboplastin Time) Heparin dosage is adjusted to keep the aPTT between 1.5 and 2.5 times the normal control level. Have antidote Protamine Sulfate readily available. Monitor for bleeding. Do not massage SubQ injection. ``` Client Eduction: Purpose of medication. Avoid OTC preparations. Bleeding precautions. Carry ID identifying product ``` A typical aPTT value is 30 to 40 seconds. If you get the test because you're taking heparin, you'd want your PTT results to be more like 120 to 140 seconds, and your aPTT to be 60 to 80 seconds.
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``` Antiplatelets: Acetylsalicylic acid (Aspirin), Clopidogrel (Plavix), Abciximab (ReoPro IV), Dipyridamole (Persantine), Eptifibatide (Integrilin), Ticlopidine (Ticlid), Tirofiban (Aggrastat), Anagrelide HCL (Agrylin) ```
``` Common Uses: Decrease platelet aggregation Arterial thrombi Thrombotic stroke TIA’s Post-MI thrombi Prevents re-occlusion post stent ``` PO/IV Interactions: Increased bleeding when taken with Dong quai, feverfew, garlic, and ginkgo biloba. Advantages: Long-term, low-dose ASA therapy has been found to be both an effective and inexpensive treatment for suppressing platelet aggregation. Side Effects: GI complaints Tinnitus Dizziness Adverse Effects: Serious Bleeding episodes Thrombocytopenia Agranulocytosis Interventions: Monitor for bleeding Safety precautions Bleeding precautions Education: Teach bleeding precautions. Notify health care provider if surgery is scheduled while on antiplatelet medication. It should be discontinued at least 7 days prior to surgery
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Hematopoietic Agent : Erythropoietin Stimulating Agents (ESAs): Epoetin alfa (Procrit), Darbepoetin alfa (Aranesp)
``` Anemia associated with: Chronic renal failure, HIV, and Chemotherapy Reduce need for blood transfusions in surgical clients. ``` Contrainducations: Uncontrolled hypertension Hypersensitivity to human albumin ``` SubQ/IV Interactions: Anticoagulants: need for an increase in heparin during hemodialysis Mechanism ``` MoA: Erythropoietin is one factor controlling the rate of red blood cell production. Side Effects: Hypertension Flushing Headache Seizures Fever Bone pain ``` Adverse Effects: Seizures Hypertensive encephalopathy CHF DVT ``` Interventions: Monitor hemoglobin. Target hemoglobin should never exceed 12g/dL Monitor Blood Pressure. Only use one dose per vial Do not shake solution, it can cause the glycoprotein to denature. 2g/dl. Monitor for seizures Client Education: Teach patient or family how to take blood pressure. Teach patient to avoid hazardous activity during treatment. Teach patients with renal disease to include high iron and low potassium foods in their diet: meat, dark green leafy vegetables, eggs and enriched breads.
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Hematopoietic Agent : Folic Acid, Vitamin B9 | (Folate) Folacin
Megaloblastic anemia Pregnancy Contraindications: Hypersensitivity Other types of Anemias ``` PO/SubQ Interactions: Estrogens, glucocorticoids, Hydantoin increase the need for folic acid. ``` MoA: Folic acid is needed for erythropoiesis to increase RBCs, WBCs and platelet formation needed in megablastic anemia and is necessary for DNA and RNA synthesis ``` Side Effects: Allergic bronchospasm Pruritus Rash General malaise Erythema ``` ``` Adverse Effects: Confusion Depression Excitability, irritability Anaphylaxis ``` Interventions: Monitor Hgb, Hct and reticulocyte count; and folate levels: 6 – 15mcg/mL baseline, throughout treatment Identify products taking that cause increase folic acid use: alcohol, oral contraceptives, estrogens, glucocorticoids. ``` Education: Teach foods high in folic acid: bran, yeast, dried beans, nuts, fruit, fresh vegetables, asparagus. Take as prescribed, do not double up Advise that urine may become dark ```
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Hematopoietic Agent: Vitamin B12 (Cyanocobalamin) Anacobin, Nascobal, Cobex
``` Vitamin B12 Deficiency, pernicious Anemia, Vitamin B12 malabsorption ``` ``` Contraindications: Optic nerve atrophy (Leber’s disease) Pregnancy and breastfeeding Cobalt Allergy ``` IM/SubQ/Nasal/Sublingual/PO ``` Interactions: Cimetidine, colchicine, chloramphenicol, aminoglycosides, anticonvulsants and potassium products cause a decreased absorption ``` ``` Side Effects: Fever Diarrhea Pruritus Flushing/itching Pain at injection site ``` ``` Adverse Effects: Cardiac failure Thrombosis Optic nerve atrophy Pulmonary edema Hypokalemia ``` Interventions Monitor potassium levels. Monitor CBC for increase in RBC, Hemoglobin. Monitor for CHF or pulmonary edema in cardiac patients Education: Life-long treatment is required for pernicious anemia. Teach foods high in B12 such as: egg yolks, fish, organ meats, dairy products, clams, and oysters.
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Immunotherapy : Interleukin-2 (IL-2), | Interferon-alfa
``` Leukemia Melanoma Non-Hodgkin’s lymphoma AIDS related Kaposi sarcoma ``` SubQ/IM MoA: Has antiviral, antiproliferative, and immune-modulatory effects, which means that these drugs inhibit intracellular replication of DNA, interferes with tumor cell growth, and enhances natural killer cell activity. Advantages: Can improve resistance to invading microorganisms and reduce cell proliferation. ``` Side Effects: Flulike syndrome Nausea/Vomiting Diarrhea Anorexia Xerostomia Taste alterations Poor concentration ``` ``` Adverse Effects: Seizures Transient aphasia Psychoses Suicidal ideation Cyanosis Orthostatic hypotension Thrombocytopenia ``` Interventions: Keep prefilled syringes in the refrigerator. Do not freeze or shake. Protect from light. Obtain baseline CBC and liver function tests. Education: Keep prefilled syringes in the refrigerator. Do not freeze or shake. Protect from light. Notify prescriber of adverse effects.
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Plasminogen Inactivators/Anti-fibrolytic Agents : Aminocaproic acid (Amicar)
Excessive bleeding from hyperfibrinolysis Contraindications: Disseminated intravascular coagulation (DIC) ``` IV/PO/1 hour Interactions: Factor IX complex: increased risk of thrombosis ``` MoA: Promotes clot formation by inhibiting plasminogen activators. Advantages: Antidote for thrombolytic therapy with excessive bleeding ``` Side Effects: Edema Headache Malaise Nausea/Vomiting Diarrhea Abdominal pain ``` ``` Adverse Effects: Uncommon and generally mild. Rare: Thrombophlebitis Orthostatic hypotension. ``` Interventions: Monitor bleeding episode. Continuous cardiac monitoring – Looking for signs of re-occlusion Monitor for signs of M
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``` Thrombolytics : Tenecteplase (TNKase), Reteplase (Retavase), Alteplase (tPA), Streptokinase, Urokinase ```
Acute MI Thrombolic stroke Pulmonary embolism DVT ``` Contraindications: Intracranial neoplasm Intracranial bleed Suspected aortic dissection Internal bleeding ``` ``` IV/5-10 mins Interactions: Increased bleeding when taken with oral anticoagulants, NSAIDs, ginkgo, garlic, ginger, green tea. Decreased effects when taken with nitroglycerin. ``` MoA: Promotes the fibrinolytic mechanism (converting plasminogen to plasmin, which destroys the fibrin in the blood clot). The thrombus disintegrates when a thrombolytic drug is administered within 4 hours after an acute MI. Necrosis is prevented or minimized. Advantages: Dissolves clot within 4 hours after an acute MI. Disadvantages; Risk for Hemorrhage ``` Side Effects: Bleeding Nausea Vomiting Fever ``` ``` Adverse Effects: Hemorrhage Anemia Bronchospasms Anaphylaxis Reperfusion anemias MI Stoke ``` Interventions: Check baseline vital signs and baseline CBC, PT, INR. Obtain medical and drug history. Bleeding history. Have Amicar readily available – Antidote. Continuous cardiac monitoring. Continuously monitor for hemorrhage for 24 hours. Initiate bleeding precautions Avoid venipuncture/arterial sticks Education: Explain thrombolytic treatment. Advise to report lightheadedness, dizziness, palpitations, nausea, pruritus, or urticaria. Avoid use of aspirin or NSAIDS for pain or discomfort.
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Normal PT and therapeutic PT
11 - 12 seconds Should be 1.5 to 2.5 the normal when on Coumadin. (15.5 - 35 seconds)
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INR and therapeutic INR
0.9 - 1.2 Should be 2 .0 - 3.0 when on Coumadin for Afib and 2.5 -3.5 for a valve
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Normal aPTT
30 to 40 seconds When on Heparin, should be 45 to 100 seconds
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Non-pharmacological ways to decrease preload
Increase HOB Dangle legs Low Salt diet
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Locations of Heart Sounds
Aortic: 2nd intercostal space to right of sternal border Pulmonic: 2nd ICS to left of sternal border Erbs: 3rd ICS to the left of sternal border Tricuspid : 5th ICS to the lower left sternal border Mitral : Apex, PMI and 5th ICS at MCL
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Sickle cell crisis
A sickle cell crisis is pain that can begin suddenly and last several hours to several days. It happens when sickled red blood cells block small blood vessels that carry blood to your bones. You might have pain in your back, knees, legs, arms, chest or stomach. The pain can be throbbing, sharp, dull or stabbing ``` Stroke. A stroke can occur if sickle cells block blood flow to an area of your brain Acute chest syndrome Pulmonary hypertension Organ damage Blindness Leg ulcers Gallstones Priapism ```
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Third Degree Heart Block
This client is experiencing third-degree atrioventricular (AV) block, or complete heart block, which involves complete inhibition of impulse conduction from the atria to the ventricles, usually at the AV node or bundle of His. The atrial and ventricular rhythms are regular but unrelated to each other. A complete heart block results in bradycardia, decreased cardiac output, syncope, and possibly heart failure/shock. The client is typically symptomatic and requires immediate treatment with transcutaneous pacing until a permanent pacemaker can be inserted. Atropine, dopamine, and epinephrine can be used to increase heart rate and blood pressure until temporary pacing is available.
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Milrinone
Milrinone (Primacor) is a phosphodiesterase-3 inhibitor given via IV infusion to increase contractility and promote vasodilation. Milrinone, an inotropic agent, is often prescribed to clients with heart failure unresponsive to other pharmacologic therapies. The medication is usually infused over 48-72 hours in a hospital setting; however, home infusion through a central line is becoming more common as a palliative measure for end-stage heart failure. Milrinone infusion requires central venous access (eg, peripherally inserted central catheter) as the medication is a vesicant and can cause extravasation if infused through a peripheral IV line. The home health nurse should perform the following: Ensure that an infusion pump is used to control the rate, and instruct the family on basic troubleshooting (Option 4). Evaluate medication effectiveness and possible side effects. Monitor the central line insertion site for infection. Change the central line dressing as prescribed (Option 3). Monitor daily weight (Option 1). Monitor blood pressure for possible hypotension (Option 2). Implement safety precautions as hypotension increases the client's risk of falling. A client may receive a milrinone infusion in the home for palliative treatment of end-stage heart failure. The infusion is set up via an infusion pump and infused through a central line. The client and family should be instructed on basic pump troubleshooting as well as the importance of measuring daily weight and blood pressure.
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BNP normal Value
<100 pg/ml
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Trop normal Value
<0.01
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CK normal Value
20-215 U/L
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C-reactive protein normal Value
<8mg/L