Cardiac

Question 1

What is an inotrope?

Answer 1

Changes the force of contractility

Question 2

What is a chronotrope?

Answer 2

Changes the heart rate

Question 3

What would you use to treat sepsis?

Answer 3

Inotropes

Question 4

Is adrenaline/noradrenaline a Beta 1, alpha 1, beta 2 adrenoceptor agonist or antagonist?

Answer 4

Agonist

Question 5

What effect does adrenaline/noradrenaline have on beta 1 adrenoceptors?

Answer 5

Increase heart rate

Increase contractility

Question 6

What effect does an agonist have on alpha 1 adrenoceptors?

Answer 6

Vasoconstriction

Question 7

What are the down sides to adrenaline/ noradrenaline as a treatment?

Answer 7

They aren’t selective

Question 8

What is Dopamine?

Answer 8

A Beta 1 selective adrenoceptor agonist

Question 9

What effect does dobutamine have? And when would you use it?

Answer 9

Increases heart rate and contractility

Acute heart failure, surgical shock, sepsis

Question 10

What drug is common heart failure treatment?

Answer 10

Digoxin

Question 11

Is Digoxin a inotrope or chronotrope?

Answer 11

Inotrope

Question 12

How does Digoxin work?

Answer 12

Stops ATPase = increase Ca in cell = inotrope

Question 13

What is angina?

Answer 13

Lack of oxygen to heart

Question 14

What would you use in acute angina?

Answer 14

GTN

Question 15

What is an issue with GTN?

Answer 15

Tolerance

Question 16

What would you use as a prophylaxis for angina?

Answer 16

Beta blocker 
(propranolol non selective)
Atenolol beta 1 selective

Question 17

In what condition should beta blockers not be used?

Answer 17

Asthma

Question 18

What are examples of calcium channel entry blockers for angina?

Answer 18

Amlodipine, diltiazem, verapamil

Question 19

Where are Beta 1 adrenoceptors?

Answer 19

Heart

Kidney

Question 20

Where are Beta 2 adrenoceptors?

Answer 20

Lung
Skeletal muscle
GI tract

Question 21

Where are Beta 3 adrenoceptors?

Answer 21

Bladder