Cardiac Failure Flashcards

1
Q

Define Cardiac Failure

A

Inability of cardiac output to meet body’s demands despite NORMAL venous pressures

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2
Q

How can cardiac failure be classified by output?

A

Low output: Decreased output
High output: Increased demand

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3
Q

Which 5 conditions predispose to left heart failure?

A
IHD
HTN
Cardiomyopathy 
Aortic valve disease  
Mitral regurgitation
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4
Q

Which 7 conditions predispose to right heart failure?

A

Secondary to left heart failure (congestive cardiac failure)
Infarction
Cardiomyopathy
Pulmonary HTN/ embolus/ valve disease
Chronic lung disease
Tricuspid regurgitation
Constrictive pericarditis/ pericardial tamponade

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5
Q

Which 4 conditions predispose to biventricular failure?

A

Arrhythmia
Cardiomyopathy (dilated or restrictive)
Myocarditis
Drug toxicity e.g. Taxanes

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6
Q

Which 6 conditions predispose to high output cardiac failure?

A
Anaemia  
Beri beri 
Pregnancy  
Paget's disease  
Hyperthyroidism 
Arteriovenous malformation
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7
Q

Describe the epidemiology of cardiac failure

A

10% of >65 yrs

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8
Q

List 4 presenting symptoms of left heart failure

A

Dyspnoea (NYHA)
Orthopnoea
Paroxysmal nocturnal dyspnoea
Fatigue

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9
Q

What causes the presenting symptoms in left heart failure?

A

Pulmonary congestion

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10
Q

List 3 additional presenting symptoms in acute left ventricular failure

A

Wheeze
Cough
Pink frothy sputum

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11
Q

List 6 presenting symptoms in right heart failure

A
Swollen ankles  
Fatigue  
Increased weight (due to oedema)  
Reduced exercise tolerance  
Anorexia 
Nausea
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12
Q

What are 6 signs of left heart failure?

A
Tachycardia 
Tachypnoea 
Displaced apex beat  
Bilateral basal crackles  
S3 gallop (rapid ventricular filling)  
Pansystolic murmur (due to functional MR)
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13
Q

What are 5 additional signs in acute left ventricular failure?

A
Cyanosis  
Peripheral shutdown  
Pulsus alternans  
Wheeze (cardiac asthma)  
Fine crackles throughout lung
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14
Q

What are 5 signs in right heart failure?

A
Raised JVP 
Hepatomegaly  
Ascites  
Ankle/sacral pitting oedema  
Signs of functional tricuspid regurgitation
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15
Q

What bloods would be taken in cardiac failure?

A
FBC 
U+Es 
LFTs 
CRP 
Glucose  
TFTs
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16
Q

What bloods must also be taken in acute left ventricular failure?

A
ABG  
Troponin 
BNP 
Raised plasma BNP suggests cardiac failure  
Low plasma BNP excludes cardiac failure
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17
Q

What is seen on a CXR in acute LV failure?

A
Alveolar oedema (bats wing shadowing)
Kerley B lines 
Cardiomegaly 
Upper lobe Diversion/ Dilated prominent upper lobe veins 
Pleural Effusion
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18
Q

What may be seen on an ECG in cardiac failure?

A

Normal
Ischaemic changes (pathological q waves, t wave inversion)
Arrhythmia or LV hypertrophy

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19
Q

What end diastolic pressures would you measure using a Swan-Ganz Catheter in cardiac failure ?

A
RA
RV
Pulmonary artery
Pulmonary wedge
LV
20
Q

What is the management plan for all patients with acute heart failure?

A

IV loop diuretics e.g Furosemide/ Bumetanide
+/- O2: 94-98%

21
Q

When should nitrates be given in management of acute heart failure?

A

If concomitant myocardial ischaemia, severe HTN, AR or MR

22
Q

What is indicated in patients with acute heart failure and respiratory failure?

A

Continuous positive airway pressure (CPAP)

23
Q

How does CPAP benefit patients in acute heart failure?

A

Increases intrathoracic pressure which reduces venous return to the heart + lowers preload
Also decreases afterload by decreasing pressure difference between LV + extra thoracic arteries

These pressure changes increase stroke volume + promote movement of fluid from interstitial fluid compartment into the intravascular fluid compartment reducing oedema + alleviating dyspnoea

24
Q

How should patients with acute heart failure and hypotension/ cardiogenic shock be managed?

A

Inotropes e.g. Dobutamine
If severe LV dysfunction + potentially reversible cause of cardiogenic shock

Vasopressors e.g. Norepinephrine
If insufficient response to inotropes + evidence of end-organ hypoperfusion

Mechanical circulatory assistance: intra-aortic balloon counter pulsation or ventricular assist devices

25
What is the first line management for chronic heart failure?
ACEi + BB Start one drug at a time
26
Which beta-blockers are licensed for use in chronic HF?
Bisoprolol Carvedilol Nebivolol
27
What is second line management of chronic heart failure? What needs to be monitored and why?
Aldosterone antagonist e.g. Spironolactone/ Eplerenone Monitor K+ as ACEi + aldosterone antagonists can cause hyperkalaemia
28
What drug can be used second line in management of chronic heart failure with reduced ejection fraction?
SGLT-2 inhibitors: dapagliflozin, empagliflozin, canagliflozin Reduce glucose reabsorption + increase urinary glucose excretion
29
What third line therapy can be initiated by a specialist for chronic HF?
Ivabradine Sacubitril-valsartan Digoxin Hydralazine + Nitrate Cardiac resynchronisation therapy
30
What is the criteria for using ivabradine?
Sinus rhythm >75 bpm Left ventricular fraction <35%
31
What is the criteria for using sacubitril valsartan?
LV fraction <35% Symptomatic on ACEi/ ARBs Must have ACEi/ ARB washout period
32
What is the purpose of digoxin in heart failure? When in particular is it indicated?
Symptomatic relief due to inotropic properties Strongly indicated if coexistent AF
33
In which patients is hydralazine and nitrate particularly indicated?
Afro-caribbean
34
What is the indication for cardiac resynchronisation therapy?
Widened QRS (LBBB)
35
What non-cardiac treatment should be offered in chronic heart failure?
Annual influenza vaccine One-off pneumococcal vaccine
36
When treating chronic heart failure what else must you do?
TREAT THE CAUSE (e.g. HTN) TREAT EXACERBATING FACTORS (e.g. anaemia)
37
What must be avoided when treating patients with heart failure?
Drugs that could adversely affect them due to systolic dysfunction: NSAIDs Non-dihydropyridine CCBs e.g. Diltiazem, Verapamil
38
List 3 possible complications of heart failure
Respiratory failure Cardiogenic shock Death
39
What is the prognosis for heart failure?
50% with cardiac failure die within 2 years
40
What conservative management advice is used for chronic heart failure?
Stop smoking Stop drinking alcohol Decrease salt intake Optimise weight + nutrition
41
Describe left heart failure
Dysfunction associated with LV
42
Describe right heart failure
Dysfunction associated with the RV | Often a result of left-sided failure.
43
How can heart failure be classified by time course?
Acute: Rapid onset Chronic: Slow onset
44
What are the 2 types of left heart failure?
Systolic: LV loses its ability to contract normally Diastolic: LV loses its ability to relax normally
45
Why perform an echocardiogram in cardiac failure?
To assess ventricular contraction. If LV ejection fraction < 40%: systolic dysfunction. Diastolic dysfunction: reduced compliance leading to a restrictive filling defect.
46
When are nitrates particularly indicated in acute cardiac failure?
Severe HTN Concurrent myocardial ischaemia/ regurgitant aortic/ mitral valve disease
47
What is the MOA of nitrates that benefits patients in acute cardiac failure?
Dilate coronary arteries, enhancing blood flow to myocardium Vasodilatory effects reduce preload + afterload