Cardio Not Included

Question 1

GWAS asthma - 2 genes

Answer 1

GSDMB
IL33

Question 2

SMART?

Answer 2

Single inhaler management and reliever therapy
Single combination therapy to deliver inhaled corticosteroids and a quick-acting LABA to patients (bronchodilator)
Encourages use of preventative inhaled corticosteroids

Question 3

Dupilumab?

Answer 3

anti-IL4Rα Ab, shared receptor for IL-4 and IL-13
Fewer asthma attacks and improved lung function

Question 4

PCSK9 inhibitors?

Answer 4

LDL enters hepatocytes via LDLR

PCSK9 degrades LDLRs

PCSK9 inhibitors now used to supplement statins

PCSK9-deficient humans are protected from cardiovascular disease

Question 5

ABCA1 ABCG1 Cholesterol export pumps?

Answer 5

Export selective to Apolipoprotein A as interactor (found on HDL)
Export to HDL is reverse cholesterol transport
Removes cholesterol from arteries and initiates return to the liver