Endo Added

Question 1

Immunology of T1DM?

Answer 1

Primary step is the presentation of auto-antigen to autoreactive CD4+ T lymphocytes
CD4+ cells activate CD8+ T lymphocytes
CD8+ cells travel to islets and lyse beta-cells expressing auto-antigen
Exacerbated by release of pro-inflammatory cytokines
Underpinned also, by defects in regulatory T-cells that fail to supress autoimmunity

Question 2

Osilidrostat MOA?

Answer 2

Blocks 17a-hydroxylase and 11b-hydroxylase