Cardio Protdctive Drugs

Question 1

Name 6 classes if cardio protective drugs?

Answer 1

Anti platelets
Ace inhibitors
Arbs
Beta blockers
Statins
SGL T2

Question 2

What is the mode of action for Atorvastatin?

Answer 2

Liquid modifying drug. Inhibits Hmg COA enzyme used to make cholesterol

Question 3

Clopidogrel- what is the mode of action

Answer 3

Clopidogrel Prevents platelet aggregation by binding to adenosine phosphate receptors. So reducing clot formation.

Question 4

What are anti platelets for?

Answer 4

To treat acute coronary syndrome

To prevent occlusion of coronary artery stents

Prevent secondary thrombotic arterial events

Question 5

Aspirin- what is the mode of action?

Answer 5

Aspirin inhibits the COX-1 enzyme, reducing thromboxane A₂ (TXA₂) production. Thromboxane A₂ promotes platelet aggregation, so its inhibition prevents platelets from clumping together, thereby reducing clot formation (antithrombotic effect)

Question 6

Pros of aspirin

Answer 6

Can be used with other anti platelets.

1st line use in acute settings.

Multi purpose use.

Question 7

Cons of Aspirin

Answer 7

GI bleed

Overdose

Hypersensitivity- bronchospasm.

Question 8

What’s the mode of action for an ARB- losartan

Answer 8

Losartan acts as an antagonist by blocking angiotensin II at the AT₁ receptor. This prevents vasoconstriction and promotes vasodilation, lowering blood pressure.

Additionally, it reduces aldosterone secretion, leading to decreased sodium and water retention.

Question 9

What are the pros of losartan

Answer 9

No cough
Slows ckd
Reduce vascular resistance.

Question 10

What are cons of losartan?

Answer 10

Risk of renal failure
Initial risk hypotension.

Question 11

What is the mode of action of Beta Blockers.

Answer 11

Beta Blockers are antagonists

The drugs attaches to the adreno receptors blocking the effect of adrenaline and noradrenaline.

Reducing heart rate and blood pressure.

Question 12

Where are the beta receptors?

Answer 12

Beta 1 heart muscles and kidneys

Beta 2. Mainly in lungs, GI tract liver

Beta 3. Fat cells and bladder.

Question 13

Name a BI antagonist?

Answer 13

Bisoprolol

Question 14

Name a non cardio selective beta blocker and mode of action.

Answer 14

Labetalol.

Alpha and beta blocker.

Reduces and blocks adrenaline and noradrenaline by binding to alpha receptor sites. Blood vessels relax