Cardiology Flashcards

(47 cards)

1
Q

What are the causes of aortic stenosis?

A

Degenerative calcification
Rheumatic heart disease
Congenital bicuspid aortic valve

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2
Q

What are the signs of severity of aortic stenosis?

A
Plateau/Anacrotic slow rising pulse
Narrow pulse pressure
Length of systolic murmur
Loud S2
S4
LVF
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3
Q

What are the indications for surgery in Aortic Stenosis? (HK)

A

Symptoms of heart failure regardless of EF
Asymptomatic patients with Severe AS & EF<50%
Severe AS undergoing other cardiac surgery
Critical AS with valve are <0.7cm2

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4
Q

What are the types of surgery available in Aortic Stenosis?

A

> Surgerical Aortic Valve Replacement
- Surgical AVR indicated in patients who meet an indication for AVR with low-intermediate surgical risk
Transcatheter Aortic Valve Implantation
- TAVI indicated in patients who meet an indication for AVR who have a prohibitive surgical risk & predicted post-TAVI survival >12 months
- Contraindications to TAVI include i) Estimated life expectancy <1 year, ii)Inadequate annulus size, iii) Thrombus in LV, iv) Active endocarditis, v) Bicuspid aortic valve

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5
Q

What are the causes of Aortic Regurgitation?

A

> Acute
-Infective endocarditis
-Aortic root rupture or Dissecting aneurysm
-Trauma
-Prosthetic valve failure
Chronic
-Congenital bicuspid aortic valve
-Rheumatic heart disease
-Seronegative arthropathy (ankylosing spondylitis)
-Aortitis in seronegative arthropathies or tertiary syphilis

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6
Q

What are the signs of severity of Aortic Regurgitation?

A
  • Collapsing water hammer pulse
  • Wide pulse pressure
  • Length of decrescendo diastolic murmur
  • Soft S2
  • LVF
  • Austin Flint Murmur (low pitched rumbling mid diastolic murmur at apex)
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7
Q

What are the indications for surgery in Aortic Regurgitation?

A
  • Symptoms of heart failure regardless of EF
  • Asymptomatic patients with Severe AR & EF <50%
  • Severe AR undergoing other cardiac surgery
  • Aortic root dilatation >50mm
  • Reduction in exercise EF >5%
  • Concomitant angina
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8
Q

What are the causes of Mitral Stenosis?

A
  • Rheumatic heart disease
  • Post mitral valve repair for MR
  • Severe mitral annular calcification
  • Congenital
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9
Q

What are the signs of severity of MItral Stenosis?

A
  • Narrow pulse pressure
  • Length of rumbling mid diastolic murmur
  • Diastolic thrill at apex
  • Opening snap
  • Loud S1
  • Pulmonary hypertension
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10
Q

What are the indications for surgery in Mitral Stenosis?

A
  • Percutaneous Mitral Balloon Commisurotomy (PMBC) is recommended for symptomatic severe MS (MVA <1.5cm2) & favourable valve morphology
  • Mitral Valve Surgery is recommended for symptomatic severe MS (MVA <1.5cm2) who are not high risk for surgery & are not candidates for PMBC.
  • Mitral Valve Surgery is recommended for severe MS undergoing other cardiac surgery.
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11
Q

What are the causes of Mitral Regurgitation?

A
>Acute
-Infective endocarditis
-Trauma
-Myocardial infarction
>Chronic
-Rheumatic heart disease
-Papillary muscle dysfunction
-Connective tissue disease
-Mitral valve proplapse
-Degenerative disease
-Congenital
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12
Q

What are the signs of severity of Mitral Regurgitation?

A
  • Soft S1
  • S3
  • LVF, LVH
  • Pulmonary hypertension
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13
Q

What are the indications for surgery in Mitral Regurgitation?

A
  • Symptomatic Severe MR with LVEF >30%

- Chronic Severe MR undergoing other cardiac surgery

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14
Q

What are the causes of Tricuspid Regurgitation?

A
  • Functional TR secondary to RVF or Pulmonary HTN
  • Rheumatic heart disease
  • Infective endocarditis
  • Ebstein’s anomaly
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15
Q

What are the signs of severity of Tricuspid Regurgitation?

A
  • Soft S1
  • Elevated JVP with v waves
  • Pulsatile tender liver
  • Ascites
  • Peripheral oedema
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16
Q

What are the indications for surgery in Tricuspid Regurgitation?

A
  • Severe TR undergoing left sided valve surgery

- Symptomatic Severe TR unresponsive to medical therapy

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17
Q

What are the causes of:

i) Dominant ‘a’ wave
ii) Dominant ‘v’ wave
iii) Cannon ‘a’ wave
iv) Increased JVP

A

i) Dominant ‘a’ wave: TS, PS, Pulmonary HTN
ii) Dominant ‘v’ wave: TR
iii) Cannon ‘a’ wave: CHB
iv) Increased JVP: RVF, TR, Constrictive pericarditis

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18
Q

What are the causes of:

i) Anacrotic slow rising pulse
ii) Plateau slow rising pulse
iii) Collapsing water hammer pulse

A

i) Anacrotic slow rising pulse: AS
ii) Plateau slow rising pulse: AS
iii) Collapsing water hammer pulse: AR

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19
Q

What are the causes of:

i) Soft S1
ii) Loud S1
iii) Soft S2
iv) Loud S2
v) S3
vi) S4

A

i) Soft S1: MR, TR
ii) Loud S1: MS, TS
iii) Soft S2: AR, PR
iv) Loud S2: AS, PS
v) S3: AR, MR, VSD, PDA
vi) S4: AS, MS, PS, HOCM
* Heart sounds are soft in Regurgitation & Loud in stenosis. S3 due to regurgitation. S4 due to stenosis.

20
Q

What are the differential diagnoses for:

i) Pansystolic murmur
ii) Ejection systolic murmur
iii) Early diastolic murmur
iv) Mid-diastolic murmur
v) Continuous murmur

A

i) Pansystolic murmur: MR, TR, VSD
ii) Ejection systolic murmur: AS, PS, HOCM, ASD
iii) Early diastolic murmur: AR, PR
iv) Mid-diastolic murmur: MS, TS
v) Continuous murmur: PDA, AVF

21
Q

What is the effect of:

i) Inspiration
ii) Expiration
iii) Left lateral decubitus position
iv) Leaning forward & expiration
v) Valsalva manoeuvre

A

i) Inspiration: Increased right sided murmurs (T/P)
ii) Expiration: increases left sided murmurs (A/M)
iii) Left lateral decubitus position: Increases MS
iv) Leaning forward & expiration: Increases AR
v) Valsalva manoeuvre: Increases HOCM & MVP, Reduces AS

22
Q

What are the causes of Pulmonary Stenosis?

A
  • Congenital

- Carcinoid syndrome

23
Q

What are the signs of severity of Pulmonary Stenosis?

A
  • Length of systolic murmur
  • Loud S2
  • S4
  • RVF, Increased JVP
  • Peripheral cyanosis secondary to reduced cardiac output
24
Q

What are thet clinical findings of Hypertrophic Obstructive Cardiomyopathy?

A
  • Sharp jerky pulse
  • Double/triple apical impulse
  • Length of ESM over LLSE (increased with valsalva)
  • S4
  • MR murmur (pansystolic murmur radiating to axilla)
25
What are the ECG & TTE findings of HOCM?
- ECG: Interor & Lateral ST & T wave changes, Deep Q waves in Inferior & Lateral leads, LVH - TTE: MR, Asymmetrical septal hypertrophy, Systolic anetior motion of anterior mitral valve leaflet (Mnemonic MR ASH SAM)
26
What are the markers of poor prognosis in HOCM?
- History of syncope - FHx of sudden cardiac death - Presence of ventricular arrhythmias - Septal thickness >18 mm on TTE - Outflow tract gradient >40mmHg at rest - Poor BP response to exercise
27
What is the treatment of HOCM? What drugs are contraindicated in HOCM?
>Treatment of HOCM: - Beta-blockers, Verapamil, Amiodarone, Diuretics may improve ventricular function - ICD to prevent sudden cardiac death - Septal ablation or myomectomy for symptom relief >Drugs Contraindicated in HOCM: -Digoxin & Vasodilators may worsen outflow tract obstruction
28
How are Congenital Heart Defects Classified?
``` >Acyanotic -VSD -ASD -PDA -Coarctation of Aorta -Ebstein's Anomaly >Cyanotic -Eisenmenger's SYndrome -Tetralogy of Fallot -Transposition of Great Vessels -Truncus Arteriosus ```
29
Atrial septal Defect What is the mechanism of ASD? What re the clinical findings? What are the indications for surgical closure?
``` >Mechanism of ASD: -Blood flows from LA to RA through PFO >Clinical Findings of ASD: -RVH/RVF -ESM in pulmonary area -Fixed splitting of S2 (Mnemonic AF) -Pulmonary HTN >Indications for Surgical Closure -Almost all cases of ASD need surgical closure -Right Ventricular Overload -Qp:Qs >1.5 (pulmonary flow: systemic flow) ```
30
Ventricular Septal Defect What is the mechanism of VSD? What are the clinical findings? What are the indications for surgical closure?
``` >Mechanism of VSD: -Blood flows from LV to RV through Ventricular septum >Clinical Findings of VSD: -Pansystolic (holosystolic) murmur along LSE louder on expiration -LVH/LVF >Indications for Surgical Closure: -CCF not responding to medical therapy -VSD with PS or AR -VSD with pulmonary hypertension -Qp: Qs >1.5 ```
31
Patent Ductus Arteriosus What is the mechanism of PDA? What are the clinical findings?
``` >Mechanism of PDA: -Blood flows from Aorta to PA -LV receives a backflow of blood from the aorta, which causes it to become volume-overloaded >Clinical Findings of PDA -Continuous machinery murmur along LSE -Reversed splitting of S2 (Mnemonic PR) ```
32
What is reversed splitting of S2? | What are the causes of reversed splitting?
>What is reversed splitting of S2? -P2 occurs before A2, rather than the usual A2-P2 >What are the causes of reversed splitting? -LBBB - due to delayed conduction -AS - due to LV delay/overload -Large PDA - due to LV overload
33
Eisenmenger's Syndrome What is Eisenmenger's Syndrome? What are the clinical findings? What is the treatment?
>Definition -Cyanotic congenital heart disease -Occurs when a left to right shunt reverses into a right to left shunt due to pulmonary pressure exceeding systemic pressure >Clinical Findings: -Youthful patient with Median sternotomy scar, Clubbing, Cyanosis, Pulmonary hypertension (loud P2, PR +/- TR) >Treatment: -Heart-Lung transplant is only curative option
34
Tetralogy of Fallot What are the four features? What are the clinical findings? What is the treatment?
``` >Features: Mnemonic PROVe -PS -RVH -Overriding Aorta -VSD >Clinical Findings: -PS (ESM in pulmonary area) -VSD (PSM in LSE) -Thoracotomy scar, Central cyanosis, Clubbing >Treatment: -Blalock-Taussig Shunt connects left subclavian artery to left pulmonary artery ```
35
Constrictive Pericarditis What are the causes? What are the clinical findings? What is the treatment?
``` >Causes -Tuberculosis -Chronic pericarditis -Incomplete drainage of purulent pericarditis -Post-MI infarction >Clinical Findings: -Cachectic, Ascites, Riased JVP with prominent x & y descents, Hepatosplenomegaly, Oedema, Pulsus Paradoxus >Treatment: -Pericardial stripping ```
36
Prostehtic Valves What are the signs? What are the complications? What are the advantages of porcine valve?
``` >Signs: -Metallic S1 - mitral valve replacement. -Metallic S2 - aortic valve replacement >Complications: -Thromboembolism, Valve dysfunction (leak, dehiscence, obstruction), Haemolysis, IE, Bleeding >advantages of Porcine Valve: -Does not require anticoagulation -However, porcine valve degenerates & undergoes calcification ```
37
Electrocardiogram What are the features of: i) RAE ii) LAE iii) RVH iv) LVH =========================
i) RAE: - P-pulmonale (tall P wave) ii) LAE: - P-mitrale (notched P wave) iii) RVH: - RAD (QRS Lead I negative, aVF positive) - Tall R wave in V1, V2 iv) LVH: - LAD (QRS Lead I positive, aVF negative) - S in V1/V2 + R in V5/V6 >35 mm - Tall R waves in V5/V6
38
Clinical and ECG findings of ASD?
>Mnemonic "QRS" - Quiet systolic murmur - Right - axis, RBBB, RVH - Secundum; Second heart sound fixed-splitting (normal A2 P2 but no variation with breathing) >Primum (associated with down Trisomy 21) - Ostium primum = LEFT ax dev (only difference) - labelled from ventricle UPwards, so primum is LOW atrium and secundum is high atrium > Common, 15% unfused foramen ovale - can right to left. including paradoxical strokes
39
What is the significance of the apex beat? | Can the apex beat be usually felt and where?
>Mnemonic: "VT, pH" -Volume loaded=>thrusting; Pressure=>Heaving -Volume => displaced; pressure=> not -Volume: AR, MR, volume overload -Pressure: AS, coarctation, HOCM >Apex, the most lateral/inferior point of clear pulsation, is usually felt at 5th intercostal space, mid-clavicular > However may NOT be felt at all! -in many not easily palpable: overweight, hyperinflated from COPD; or other distances- pleural effusion, pericardial effusion, cardiomyopathy -if impalpable, you must check for dextrocardia -if impalpable say so: this is a valid finding
40
What are the causes of a collapsing pulse?
``` >Independent and hyperdynamic >Mnemonic "A Collapsing Pulse" (independent and more pronounced) -AR (look for early diastolic murmurs) -Cirrhosis -Patent ductus arteriosus >Mnemonig "Think Exercise And Preg" (hyperdynamic) -Thyrotoxicosis (look for eye disease) -Exercise, Emotion -Anaemia/AV fistula -Pregnancy/Pyrexia ```
41
What are the congenital heart conditions?
``` >Mnemonic: "3 holes, 3 blocked tubes, 3 blue babies" >3 holes (ASD, VSD are the most common two) -ASD -VSD- may close spontaneously; small ones may req no further intervention but prophylaxis SBE; mod-large symptomatic are at risk of eisenmenger, Rt to Lt (cyanosis and clubbing); and get surgery -PDA >3 blocked tubes -AS -PS -Coarctation of aorta >3 blue babies -Tetralogy of fallot -Truncus arteriosus -Transposition of the great vessels ```
42
What does digoxin do to the QT interval? Where should it be used cautiously? What does toxicity look like?
>QT mnemonic "Digoxin is a little QT" - Shortens QT (unlike amiodarone, phenothiazine largactil, quinidine, tetracycline) - also reverse tick (though this not necessarily toxic) >Caution: -contraindicated in WPW (accessory pathway used after AV node blocked) -CKD/AKI - cleared through kidneys >Toxicity -Arrhythmias, particularly AV block, GI symptoms (n/v/d) -yellow vision (xanthopsia)
43
What are the causes of Eisenmenger? What are the 3 clinical findigns? Expected ECG findings?
>Mnemonic "Holes+Hypertension" -Holes: ASD, VSD, PDA -Pulmonary HTN (Left to Right shunt reverses) >3 Clinical Findings -Findings: Cyanosis, Clubbing, Pulm HTN >ECG findings: - RVH, (R in V1, S in V5, >12 small squares-- whereas LVH is 7 small squares) >CXR: pulm HTN - prominent vascular markings, peripheral pruning
44
Endocarditis findings?
>mnemonic: "Infected Valves Mean Endocarditis" -Infective: malaise, fever, wt loss -Vasculitis: Splinter haemorrhages, small infarcts seen in the nail, Janeway lesions are palmar macules; Oslers nodes are painful finger pulp lesions, Roth's spots are black spots on the fundus -Murmus -Emboli >Common cause: strep viridans, staph aureus; -(strep bovis is assoc with CRC requires scope f/up)
45
Empiric Ix/treatment for endocarditis?
>mnemonic "3 cultures, 3 drugs, 2/4/6-weeks" - 3 blood cultures - Benpen 1.8g q4h, Fluclox 2g q4h, Gent - If prosthetic: Fluclox, Vanc, Gent - Antibiotics for 2 weeks inpatient, at least 4-6 weeks
46
Most common valves in endocarditis? | Most common in IVDU?
Although mostly left sided valves; exception in IVDU in whom tricuspid is most common (particle damages the surface)
47
What findings make up Fallots Tetralogy?
>Mnemonic: "PROVe" -Pulmonary stenosis (pressure drop >10mmHg) -Right ventricular hypertrophy -Overriding aorta (this and VSD can be investigated by catheter comparing sats at aorta being lower than LV) -VSD >Facts -most common cause cyanosis in young patient -most will have had correction >Findings -clubbing, central cyanosis -unilaterally weak radial pulse (Blalock-Taussig shunt) -midline thoracotomy scar -left parasternal heave (of right ventricular hypertrophy or RVH) -loud ejection systolic murmur (PS murmur; accentuate right sided murmurs by asking to inspire maximally)