cardiopum week 11: respiratory physiology Flashcards

(93 cards)

1
Q

On which side of the bronchial tree does aspiration pneumonia & choking occur more often on & why?

A

R side is more vertical & shorter

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2
Q

Which zone in bronchial tree is where air is pushed through but there’s no respiration (also known as dead space)?

A

Conducting zone

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3
Q

At what level of the bronchial tree does bronchitis occur?

A

Respi bronchioles (17-19)

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4
Q

Describe the order of bronchial tree.

A

Conducting zone: larynx, trachea, primary bronchi, secondary bronchi, tertiary bronchi, small bronchi, bronchioles, terminal bronchioles.

Respiratory zone: resp bronchioles, alveolar sac.

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5
Q

What type of patient can hypercapnia & hypoxemia be seen in?

A

COPD

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6
Q

What 4 muscles promote pressure gradient (lower pressure in thoracic)?

A
  • intercostals
  • diaphragm
  • SCM
  • scalenes
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7
Q

Describe the difference between levels of atmospheric pressure, intrapulmonic pressure, & intrapleural pressure @ rest.

A
  • atmospheric = intrapulmonic
  • intrapleural less than both
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8
Q

What is the significance of intrapleural pressure being lower than atmospheric during inspiration?

A

Keeps lungs expanded

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9
Q

Describe the difference between levels of atmospheric pressure, intrapulmonic pressure, & intrapleural pressure @ inspiration.

A

Both intrapulmonic & intrapleural lower than atmospheric but intrapleural is the lowest out of the 3.

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10
Q

Describe the difference between levels of atmospheric pressure, intrapulmonic pressure, & intrapleural pressure @ expiration.

A
  • intrapulmonic higher than atmospheric
  • intrapleural lower than both
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11
Q

What is minute ventilation & what is needed for there to be an adequate level of it?

A
  • in/out in a min (tidal volume x RR)
  • alveoli need to be ventilated, lungs must expand & collapse to move enough volume, air must flow through airways @ good rate, minimal barrier b/t alveolar air & pulm capillary for O2
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12
Q

Alveoli are better ventilated when there’s an (increase/decrease) in RR & an (increase/decrease) in tidal volume.

A
  • decrease
  • increase
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13
Q

What is the significance of RBCs needing to pass close to the alveolar-capillary wall?

A

Because O2 doesn’t diffuse as well or fast as CO2

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14
Q

How does pulmonary edema or any disease that has fluid/scar tissue cause hypoxemia?

A

Makes space b/t capillaries & alveoli bigger so blood goes through capillaries slower

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15
Q

What are levels of CO2 influenced by mostly? How about O2?

A
  • CO2: changes in vent
  • O2: changes in vent & diffusion
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16
Q

What are the 2 compartments of the trunk & what structure regulates the pressure?

A
  • thorax & abd
  • diaphragm
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17
Q

What seals the trunk @ both ends?

A

Larynx & PF muscles

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18
Q

How does intrathoracic pressure change when pt is holding breath & lifting heavy? How does this affect venous return?

A

Increase intrathoracic pressure –> decrease venous return

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19
Q

What lowers surface tension in the lungs to allow it to expand since it has tendency to collapse?

A

Surfactant

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20
Q

What is functional residual capacity?

A
  • amt of air left in lung after normal exhalation
  • balance point of lung recoil & chest wall forces
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21
Q

Amount of opposing forces b/t thorax & lungs causes ________ intrapleural pressure.

A

Negative

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22
Q

What type of conditions would paralyze surfactant producing cells which would lead to a collapsed lung?

A

Burn, inhalation injury, acute distress

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23
Q

If intra-alveolar pressure is lower than atmospheric pressure, what can occur w/ a deep breath?

A

Air can get all the way to alveoli

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24
Q

What type of pressure is due to interaction of lung & chest wall forces that is usually negative but can be positive w/ effusions, scarring, & inflammation?

A

Intrapleural

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25
Intra-alveolar pressure is negative on __________ & positive on __________.
- inhalation - exhalation
26
Where is pressure most negative during inhalation & positive during exhalation?
Distal airways
27
How do small airways expand & remain open during inhalation?
Neg intrathoracic pressure
28
In which position does diaphragm want to go up? How does this affect FRC?
Supine --> FRC decreases
29
T/F: Exhalation is active @ rest.
F (passive)
30
What does CPAP do to help increase FRC?
Inflate lungs & push diaphragm down
31
In pts w/ restrictive diseases, describe their lung compliance & the resulting pressure during exhalation.
- hypocompliant - higher pos pressure gradient
32
What type of compliant lungs such as in obstructive diseases retain O2?
Hyper
33
What 4 things make up total lung volume?
- IRV - TV - ERV - RV
34
What 2 things make up inspiratory capacity?
- inspiratory reserve volume - tidal volume
35
What 2 things make up FRC?
- expiratory reserve volume - residual volume
36
What is vital capacity?
How much air in/out maximally
37
What is inspiratory reserve volume? How about expiratory reserve volume?
- amt of air inhaled above TV - exhaled below TV
38
How is residual volume affected in COPD overtime & why?
Increases bc hard time exhaling
39
How is total lung volume affected in obstructive vs restrictive?
- obstructive: increases - restrictive: decreases
40
What is the term for amt of air moved in/out each breath?
TV
41
What is the term for air left after max expiration?
Residual volume
42
What is the term for max volume one can inspire during inspiratory effort?
Inspiratory capacity
43
What is the term for max volume one can exchange in 1 cycle?
Vital capacity
44
What is the term for air in lungs @ full inflation?
Total lung capacity
45
What 3 things make up vital capacity?
- IRV - TV - ERV
46
Which 3 static lung volumes/capacities cannot be measured w/ basic spirometry?
- RV - FRC - TLC
47
How are VC, IRV, & IC affected w/ restrictive?
Decrease
48
T/F: Expiratory flow is measured w/ normal exhalation.
F (forced)
49
What is FEV1? What % should it be at?
- forced expiratory volume in 1 sec - > 80% of predicted
50
What is FEV1/FVC? What % should it be at?
- % of vital capacity exhaled in 1 sec of forced exhalation - > 70%
51
What type of pts have below 80% of FEV1 & below 70% of FEV1/FVC?
Obstructive
52
How is FRC & RV affected w/ increased lung compliance (over compliant lungs)?
Also increase
53
How does increased lung compliance affect PaO2 & PaCO2?
- decrease O2 - increase CO2
54
Increased lung compliance --> _________ intrathoracic pressure & _______ airway resistance on exhalation.
- decreased (more neg) - increased
55
What type of pt has increased lung compliance (be specific)?
Emphysema
56
Besides RV, what else is decreased when there's decreased lung compliance?
VC, IRV
57
Airway resistance progressively _________ w/ decreased lung volumes & forced exhalation.
Increases
58
Inhalation & exhalation flow rates are diff, what does exhalation flow depend on?
Lung volume
59
What does alveolar ventilation + dead space ventilation =?
TV
60
T/F: Increasing breathing rate increases both alveolar vent & dead space vent.
T
61
What does increasing tidal volume when breathing increase in terms of ventilation?
Alveolar only
62
What 3 diseases can lead to perfusion w/o ventilation?
- pneumonia - COPD - asthma
63
What can lead to ventilation w/o perfusion?
Pulm embolus
64
In areas w/ high relative vent & high V/Q, does O2 or CO2 have the higher conc?
O2
65
Which region of the lungs contribute the greatest quantity of O2 to the body due to large amt of blood flow?
Bases
66
Why would sidelying w/ affected side up w/ pneumonia/consolidation of right lung help?
Better ventilation/oxygenation bc more upwards
67
Which membrane does O2 diffuse across to enter bloodstream? How about through plasma --> erythrocyte?
- alveolar capillary - pulmonary capillary
68
63 mmHg is the net driving force to move (O2/CO2) out of alveoli & 6 mmHg is net driving force to move (O2/CO2) into alveoli.
- O2 - CO2
69
55 mmHg is the driving force to move oxygen from where to where?
Arterial system to tissues
70
6 mmHg is the driving force to move CO2 into venous system --> lungs.
71
What are some disorders that affect diffusion?
- bronchopulm dysplasia - chronic fibrotic pulm disorders - pulm edema/pneumonia - ARDS/IRDS - pulm HTN - restrictive
72
What is the normal value of pulm arterial pressure?
20 mmHg @ rest, can be 25-30 w/ exercise
73
What determines PaO2 of blood to help regulate respiration?
Dissolved O2 in blood
74
What 3 factors cause Hgb to release O2 & shift curve to the RIGHT?
- lowered pH - increased PCO2 - increased temp
75
How do disorders that reduce alveolar ventilation affect PaCO2?
Increase it
76
What is the most common way CO2 is found in body?
Bicarb (HCO3-)
77
When does bicarb serve as a buffer?
Metabolic acidosis or alkalosis
78
What is the term for deep & rapid breathing due to diabetic ketoacidosis or metabolic acidosis?
Kussmaul's
79
What structures pick up on H+/CO2 conc?
Central chemoreceptors
80
What are peripheral chemoreceptors/carotid bodies sensitive to?
PO2 in arteries
81
Stretch receptors in the lungs trigger (inhalation/exhalation).
Exhalation
82
What level of PaO2 would stimulate breathing?
< 60 mmHg
83
What is the #1 reason for hypoxemia?
V/Q mismatch
84
T/F: Right-to-left shunt cannot be helped by supp O2.
T
85
What is the term for when blood bypasses regions of lung --> L heart to be pumped?
Large intrapulmonary shunt
86
What cause of hypoxemia does CNS depression & morbid obesity cause?
Hypoventilation
87
From which 3 arteries can blood be drawn for ABG studies?
- radial - brachial - femoral
88
What level of PaO2 = hypoxemia usually due to diffusion issue but can also be bc hypovent?
< 80 mmHg
89
Which pts could PaO2 be chronically low in (<50 mmHg)?
COPD
90
T/F: Low PaO2 can be associated w/ decreased SaO2.
T
91
What ABG determines ventilation?
PaCO2
92
What level of PaCO2 is hypercapnia? What about hypo?
- hyper > 45 - hypo < 35
93
Increased excretion of HCO3- (lowers/raises) pH.
Lowers