cardiovascular and lymphoid system Flashcards

(443 cards)

1
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2
Q

Where is the base of the fibrous pericardium attached?

A

It is attached to the central tendon of the diaphragm and a small muscular area of the diaphragm on the left side.

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3
Q

What is the function of the fibrous pericardium?

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It retains the heart in position in the thoracic cavity and limits cardiac distention.

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3
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What are the anterior attachments of the fibrous pericardium?

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It is attached to the posterior surface of the sternum by the sternopericardial ligaments.

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4
Q

Which nerves pass through and innervate the fibrous pericardium?

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The phrenic nerves (C3 to C5) pass through and innervate the fibrous pericardium.

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4
Q

How are the parietal and visceral layers connected?

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They are continuous around the roots of the great vessels at two main reflections:

Superiorly → Surrounding the aorta and pulmonary trunk

Posteriorly → Surrounding the superior and inferior vena cava and the pulmonary veins

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5
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What are the two layers of the serous pericardium?

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Parietal layer → Lines the inner surface of the fibrous pericardium

Visceral layer (epicardium) → Covers the heart itself

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6
Q

What vessels supply the fibrous pericardium?

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It is supplied by the pericardiacophrenic vessels.

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7
Q

What is the oblique pericardial sinus?

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A cul-de-sac located posterior to the left atrium, formed by the reflection of the serous pericardium around the veins.

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8
Q

What is the transverse pericardial sinus?

A

A passage between the two main reflections of serous pericardium, situated:

Posterior to the ascending aorta and pulmonary trunk

Anterior to the superior vena cava

Superior to the left atrium

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9
Q

Which arteries supply the pericardium?

A

Internal thoracic artery

Pericardiacophrenic artery

Musculophrenic artery

Inferior phrenic artery

Thoracic aorta

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10
Q

How can the sinuses be located during surgery?

A

A finger placed in the transverse sinus separates arteries from veins.

A hand moved under the heart apex slips into the oblique sinus.

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11
Q

How is venous blood from the pericardium drained?

A

Via the azygos vein system, internal thoracic veins, and superior phrenic veins.

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12
Q

Which nerves supply the pericardium?

A

Vagus nerve (X)

Sympathetic trunks

Phrenic nerves (C3, C4, C5)

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13
Q

Which nerve carries pain sensations from the pericardium?

A

Phrenic nerves carry somatic afferent fibers responsible for pericardial pain.

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14
Q

Where is pericardial pain typically referred to?

A

The supraclavicular region of the shoulder or the lateral neck area, corresponding to dermatomes C3, C4, and C5.

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15
Q

What type of organ is the heart and where is it located?

A

It is a fibromuscular, hollow organ located in the mediastinum.

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15
Q

How many chambers and valves does the heart have?

A

Four chambers (2 atria and 2 ventricles) and four valves (Tricuspid, Pulmonary, Mitral, Aortic).

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15
Q

What is the orientation of the heart’s apex and base?

A

Apex → Directed left, inferiorly, and anteriorly

Base → Directed right, superiorly, and posteriorly

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16
Q

What is the shape of the heart?

A

It is rounded, conical, and 3-dimensional pyramidal in shape.

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17
Q

What factors influence the size of the heart?

A

The size of the heart depends on sex, age, and fitness level of an individual.

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18
Q

What is the main function of the heart?

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To pump blood throughout the body.

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19
Q

What are the three layers of the heart wall?

A

Epicardium → Outer layer

Myocardium → Middle muscular layer

Endocardium → Inner endothelial layer

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19
Q

What is the protective sac around the heart called?

A

The pericardium.

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20
What are the three main surfaces of the heart?
Sternocostal surface (anterior) Mediastinal surface (posterior) Diaphragmatic surface (inferior)
21
What are the five regions of the primitive heart tube and what do they become?
Truncus Arteriosus → Ascending aorta and pulmonary trunk Bulbus Cordis → Right ventricle Primitive Ventricle → Left ventricle Primitive Atrium → Anterior parts of both atria and auricles Sinus Venosus → Posterior right atrium, SA node, and coronary sinus
21
What are the four borders of the heart and what do they contain?
Right border → Right atrium Inferior border → Left and Right ventricles Left border → Left ventricle Superior border → Right and Left atria, along with the great vessels
22
From which embryological tissue does the heart develop, and when?
From mesoderm around 18–19 days after fertilization. → Begins pumping blood around 21–22 days after fertilization.
23
What is the sequence of heart development?
Cardiogenic area forms near the head of the embryo. Cardiogenic cords develop. Endocardial tubes form from the cords. The two tubes fuse to form one primitive heart tube.
24
When does the primitive heart tube begin to fold and form an S shape?
Around 23–28 days after fertilization.
24
How many chambers does the heart have and what are they?
Four chambers: Two Atria (Right and Left) Two Ventricles (Right and Left
25
What important events occur by the end of the 5th week of development?
Septation and valve formation begin. Remodeling of the chambers. Partitioning of atria and ventricles.
26
When do the atrioventricular (Tricuspid) valves and semilunar (Bicuspid) valves form?
Tricuspid valves → 5th to 8th week Semilunar valves → 5th to 9th week
27
How does blood flow through the heart?
Blood enters the Atria, passes through the Atrioventricular valves into the Ventricles, and is then pumped into the arteries. → Left Ventricle → Aorta → Systemic Circulation → Right Ventricle → Pulmonary Artery → Pulmonary Circulation
28
What structure separates the Sinus Venarum and Atrium Proper?
The Cristae Terminalis, a muscular ridge.
28
What separates the atria and ventricles?
Interatrial septum → Separates the right and left atria Interventricular septum → Separates the right and left ventricles
29
What type of blood does the left atrium receive and from where?
Oxygenated blood from the four pulmonary veins
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What type of blood does the right atrium receive and from where?
Deoxygenated blood from the Superior and Inferior Vena Cava and the Coronary sinus.
30
What are the two parts of the right atrium?
Sinus Venarum → Smooth-walled region that receives blood from the vena cavae Atrium Proper → Anterior region with rough pectinate muscles
31
What forms the posterior border of the heart?
The left atrium.
31
What are the main inflow and outflow tracts of the right ventricle?
Inflow tract → Located posteroinferiorly, covered with trabeculae carneae Outflow tract (Conus Arteriosus/Infundibulum) → Funnel-shaped, smooth-walled, located anterosuperiorly
32
What valve remnant is found in the left atrium?
The valve of the Foramen Ovale, visible near the interatrial septum.
33
What are the types of trabeculae carneae in the right ventricle?
Ridges → Attach along their length Bridges → Attached at both ends but free in the middle Pillars (Papillary muscles) → Anchored at the base, connected to chordae tendineae
34
What is the structure of the left ventricle?
Conical-shaped, divided into: Inflow tract → Covered with trabeculae carneae Outflow tract (Aortic Vestibule) → Smooth-walled, leads to the aorta
35
What valve regulates blood flow from the left atrium to the left ventricle?
The Mitral (Bicuspid) valve.
36
How many papillary muscles are in the left ventricle?
Two papillary muscles: Anterior papillary muscle → Arises from the sternocostal surface Posterior papillary muscle → Arises from the diaphragmatic surface
37
What are the two parts of the interventricular septum?
Membranous part → Thin (1 mm thick) Muscular part → Thicker (~1.2 cm)
38
Which valve leaflet arises from the membranous part?
The septal leaflet of the tricuspid valve
39
What are the four cardiac valves?
Atrioventricular Valves Tricuspid valve → Right atrium to right ventricle Mitral (Bicuspid) valve → Left atrium to left ventricle Semilunar Valves Pulmonary valve → Right ventricle to pulmonary artery Aortic valve → Left ventricle to aorta
40
How many cusps does the tricuspid valve have?
Three cusps: Anterior, posterior, and septal.
40
What are the structural features of AV valves?
Made of connective tissue covered by endocardium Chordae tendineae arise from the free margins and inferior surfaces Supported by papillary muscles
41
How many cusps does the mitral valve have?
Two cusps: Anteromedial and posterolateral.
42
What are the three layers of the heart wall?
Epicardium → Outer layer Myocardium → Middle muscular layer Endocardium → Inner endothelial layer
42
What is unique about the structure of semilunar valves?
They have three cusps with nodules in the center and thin crescent-shaped rims called lunules.
42
Where are the semilunar valves located?
At the junction of ventricles and arteries: Pulmonary valve → Between right ventricle and pulmonary trunk Aortic valve → Between left ventricle and ascending aorta
43
What is found near the semilunar cusps in the aorta?
Aortic sinuses, from which the coronary arteries arise.
44
What is the myocardium composed of?
Cardiac muscle → Large involuntary striated muscle fibers supported by a collagen framework.
44
What is the structure and function of the epicardium?
The outer surface of the myocardium Lined with a shiny, smooth surface of simple squamous epithelium Formed by mesothelium, connective tissue, and a subepicardial fat layer The connective tissue secretes lubricating fluid into the pericardial cavity
45
What is the role of the myocardium?
It is responsible for the contraction of the heart, pumping blood throughout the body.
46
How is the atrial myocardium structured?
It consists of two layers: Superficial layer → Extends over both atria, thicker on the anterior side. Deep layer → Contains looped fibers that pass around the atrioventricular orifices and veins.
47
What are the three layers of the ventricular myocardium?
Subepicardial layer → Right atrium: fibers run horizontally. Left atrium: fibers run longitudinally towards the diaphragm. At the apex, forms the vortex of the heart. Middle layer → Present in the left ventricle and interventricular septum. Subendocardial layer → Forms the trabeculae carneae and papillary muscles.
48
What is the structure and function of the endocardium?
The inner lining of the myocardium Consists of endothelial cells (simple squamous epithelium) and loose connective tissue It lines the heart chambers and valves Involved in regulating contraction and cardiac embryological development
49
What is the fibrous skeleton of the heart?
A high-density connective tissue structure that: Forms and anchors the valves Insulates electrical impulses between atria and ventricles Maintains the integrity of the valve openings
50
What are the two main fibrous trigones?
Right Fibrous Trigone → Where the aortic valve, tricuspid valve, and mitral valve meet. Left Fibrous Trigone → Where the aortic valve and mitral valve meet.
51
Is the pulmonary valve anchored by the cardiac muscle?
No, the pulmonary valve is not anchored by any significant extension of cardiac muscle.
52
What vessels supply the heart with blood?
The coronary arteries, which branch off from the aortic sinus of the ascending aorta.
53
How many main coronary arteries are there, and where do they originate?
Two main coronary arteries: Right Coronary Artery (RCA) Left Coronary Artery (LCA) → Both arise from the aortic sinuses of the ascending aorta.
54
When does blood enter the coronary arteries?
During diastole when the heart is relaxed → Blood backflows, filling the valve pockets and entering the coronary arteries.
55
Where does the RCA travel, and what are its main branches?
Initially covered by the right auricle Distributes branches to the right atrium and anterior surface of the right ventricle Gives off the right marginal artery Travels in the coronary sulcus to the posterior interventricular sulcus Terminates as the posterior interventricular artery
56
What does the RCA supply?
Right atrium Conducting system (SA and AV nodes) Right ventricle Posterior part of the interventricular septum Adjacent diaphragmatic surface of the heart
57
Where does the LCA travel, and what are its main branches?
Passes between the pulmonary trunk and left auricle Divides into: Anterior interventricular artery → Travels in the anterior interventricular sulcus Circumflex artery → Runs posteriorly in the coronary sulcus
58
What does the LCA supply?
Left ventricle (most of it) Anterior portion of the interventricular septum Part of the right ventricle Sternocostal surface of the heart Left atrium
59
How is venous blood from the heart drained?
Five main tributaries drain into the coronary sinus, which then empties into the right atrium.
60
What are the five main tributaries of the coronary sinus?
Great Cardiac Vein Originates from the apex of the heart Follows the anterior interventricular groove into the coronary sulcus Small Cardiac Vein Located on the anterior surface Passes around the right side to join the coronary sinus Middle Cardiac Vein Drains the right side Runs along the posterior surface of the heart Left Marginal Vein Drains the left posterior side of the heart Left Posterior Ventricular Vein Located in the center, runs along the posterior interventricular sulcus to join the coronary sinus
61
What is the function of the heart's conducting system?
It consists of specialized cardiac muscle cells that generate and conduct rhythmic impulses to stimulate the beating of the heart.
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What are the four main components of the conducting system?
Sinoatrial (SA) Node Atrioventricular (AV) Node Bundle of His (AV Bundle) Purkinje Fibers
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Where are the main clusters of conducting cells located?
In two nodular structures: Sinoatrial (SA) Node Atrioventricular (AV) Node
64
What is the SA node's function?
It is the cardiac pacemaker that initiates the action potential causing the atria to contract.
65
Where is the SA node located?
Beneath the epicardium on the posterior surface of the right atrium, near the opening of the superior vena cava in the sulcus terminalis cordis
66
What is the size and shape of the SA node?
It is 10 mm long and spindle-shaped.
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What is the AV node's primary role?
It receives impulses from the atria, delays the signal to allow complete atrial contraction, and then transmits the impulse to the ventricles.
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Where is the AV node located?
In the interatrial septum, between the coronary sinus and the septal cusps of the tricuspid valve — also known as the Triangle of Koch.
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What is the size of the AV node?
Approximately 5 mm long.
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What is the role of the Bundle of His?
It is a direct continuation of the AV node that carries impulses to the Purkinje fibers, spreading the electrical signal to the ventricles.
71
How does the Bundle of His divide?
It splits into two branches: Right Bundle Branch → Travels downwards into the septomarginal trabeculae to reach the anterior papillary muscle. Peripheral branches form the subendocardial plexus. Left Bundle Branch → Fans out as a flat bundle along the interventricular septum. Divides into two major branches to supply the papillary muscles and form the subendocardial network.
72
What are Purkinje fibers?
They are modified cardiac muscle fibers that arise from the bundle branches of the Bundle of His.
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What is the role of Purkinje fibers?
They spread the impulse throughout the ventricular myocardium, ensuring coordinated contraction of the ventricles.
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What is a unique characteristic of Purkinje fibers?
They have high glycogen accumulation in the central portion of the cell, making them more resistant to fatigue.
75
What is the main function of arteries?
Arteries carry oxygenated blood away from the heart to the tissues of the body.
76
What are the three layers of the arterial wall?
Tunica Intima → Innermost layer, composed of endothelium and a thin layer of connective tissue. Tunica Media → Middle layer, composed mainly of smooth muscle and elastic fibers. Tunica Adventitia (Externa) → Outer layer, consisting of connective tissue, collagen fibers, and nerve fibers.
77
How are arteries classified?
Elastic Arteries → Large arteries like the aorta and pulmonary arteries, which contain many elastic fibers for stretching and recoiling. Muscular Arteries → Medium-sized arteries with more smooth muscle, controlling blood flow and pressure. Arterioles → Smallest arteries that lead into the capillaries and regulate resistance and pressure
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What is the role of arterioles?
They regulate blood flow into the capillary networks through vasoconstriction and vasodilation.
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What is the main function of veins?
Veins carry deoxygenated blood from tissues back to the heart.
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What are the three layers of the venous wall?
Tunica Intima → Contains endothelium and valves to prevent backflow. Tunica Media → Thinner than in arteries, contains smooth muscle. Tunica Adventitia (Externa) → Thicker than in arteries, composed of connective tissue.
81
How are veins classified?
Large Veins → Include the superior and inferior vena cava. Medium Veins → Found alongside muscular arteries, with valves to prevent backflow. Venules → Small veins that collect blood from capillaries and drain into larger veins.
82
What is the function of venous valves?
They prevent backflow of blood, especially in the lower extremities against gravity.
83
What are the main structural differences between arteries and veins?
Wall Thickness → Arteries have thicker walls than veins. Lumen Size → Veins have a wider lumen. Valves → Veins have valves, arteries do not. Elasticity → Arteries are more elastic to accommodate pressure surges.
84
Which vessel type is under higher pressure, arteries or veins?
Arteries, due to direct pumping from the heart.
85
What role do capillaries play in the vascular system?
They allow exchange of gases, nutrients, and wastes between blood and tissues.
86
How many layers do capillaries have?
Capillaries have one single layer of endothelial cells.
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What are the three types of capillaries?
Continuous Capillaries → Found in muscles and nervous tissue, with uninterrupted lining. Fenestrated Capillaries → Found in kidneys and intestines, with small pores for increased permeability. Sinusoidal Capillaries → Found in the liver and bone marrow, with large gaps to allow passage of large molecules.
88
What are the three layers of the blood vessel wall?
Tunica Interna (Intima) Tunica Media (Media) Tunica Externa (Adventitia)
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What is the structure of the tunica interna?
It is the innermost layer of the blood vessel wall. Composed of simple squamous epithelium (endothelium) arranged longitudinally. Rests on a basement membrane. Contains a subendothelial layer of connective tissue.
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What special structure is found in arteries within the tunica interna?
A fenestrated elastic membrane called the internal elastic membrane.
91
What is the structure of the tunica media?
It is the middle layer of the vessel wall. Composed of smooth muscle cells arranged in concentric spirals. Contains elastic fibers interwoven with the smooth muscle. It is thicker in arteries than in veins.
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What is the main function of the tunica media?
It regulates the luminal diameter of the vessel, allowing it to adjust shape in response to blood pressure changes.
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What is the structure of the tunica externa?
It is the outermost layer of the vessel wall. Consists of connective tissue with collagen fibers and elastic fibers. In veins, it also includes smooth muscle cells arranged longitudinally.
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What is the primary function of the tunica externa?
It provides structural support and protection to the vessel, and anchors it to surrounding tissues.
95
What is the structure of capillaries?
Capillaries have very thin walls, composed of only endothelial cells. They lack tunica media and tunica externa.
96
What is the typical diameter of a capillary?
Approximately 5–7 micrometers in width.
97
What is the primary function of capillaries?
They connect arteries and veins and allow for the exchange of gases, nutrients, and waste products between blood and tissues.
98
What is the main function of the pulmonary circulation?
It carries deoxygenated blood from the heart to the lungs for oxygenation and then returns oxygenated blood back to the heart to be pumped through systemic circulation.
99
What are the main vessels involved in the pulmonary circulation?
Pulmonary Artery → Carries deoxygenated blood from the right ventricle to the lungs. Capillaries → Surround the alveoli in the lungs, allowing for gas exchange. Pulmonary Vein → Carries oxygenated blood from the lungs back to the left atrium.
100
Describe the pathway of deoxygenated blood through the pulmonary circulation.
Superior and Inferior Vena Cava bring deoxygenated blood from the body to the right atrium. Blood flows through the tricuspid valve into the right ventricle. When the right ventricle contracts, blood is pushed through the pulmonary valve into the pulmonary artery. The pulmonary artery carries the blood to the lungs.
101
What happens to the blood in the lungs during pulmonary circulation?
In the lungs, gas exchange occurs in the alveolar capillaries. Carbon dioxide is removed from the blood, and oxygen is absorbed.
102
Describe the pathway of oxygenated blood back to the heart.
Oxygenated blood from the lungs travels through the pulmonary veins. It enters the left atrium. It flows through the mitral (bicuspid) valve into the left ventricle. Finally, it is pumped out through the aortic valve into the aorta for systemic circulation.
103
What is unique about the pressure in the pulmonary circulation compared to systemic circulation?
Pulmonary circulation operates under lower pressure compared to the systemic circulation.
103
What is the main function of the pulmonary circulation?
To carry deoxygenated blood from the heart to the lungs for oxygenation and then return oxygenated blood back to the heart to be pumped through systemic circulation.
104
Why is the pressure lower in pulmonary circulation?
The lungs are closer to the heart, and the capillary network is delicate, requiring less pressure for efficient gas exchange.
105
How does the structure of pulmonary vessels support gas exchange?
Pulmonary capillaries have thin walls for efficient diffusion of gases. The alveolar-capillary membrane is highly permeable to both oxygen and carbon dioxide.
106
What are the main vessels involved in the pulmonary circulation?
Pulmonary Artery → Carries deoxygenated blood from the right ventricle to the lungs. Capillaries → Surround the alveoli in the lungs, allowing for gas exchange. Pulmonary Vein → Carries oxygenated blood from the lungs back to the left atrium.
107
Describe the pathway of deoxygenated blood through the pulmonary circulation.
Superior and Inferior Vena Cava bring deoxygenated blood from the body to the right atrium. Blood flows through the tricuspid valve into the right ventricle. When the right ventricle contracts, blood is pushed through the pulmonary valve into the pulmonary artery. The pulmonary artery carries the blood to the lungs.
108
What happens to the blood in the lungs during pulmonary circulation?
In the lungs, gas exchange occurs in the alveolar capillaries. Carbon dioxide is removed from the blood, and oxygen is absorbed.
109
Describe the pathway of oxygenated blood back to the heart
Oxygenated blood from the lungs travels through the pulmonary veins. It enters the left atrium. It flows through the mitral (bicuspid) valve into the left ventricle. Finally, it is pumped out through the aortic valve into the aorta for systemic circulation.
110
What are the main branches of the pulmonary artery?
The pulmonary trunk leaves the right ventricle and bifurcates into: Right Pulmonary Artery → Supplies the right lung Left Pulmonary Artery → Supplies the left lung
111
How do the pulmonary veins return blood to the heart?
There are typically four pulmonary veins (two from each lung) that directly enter the left atrium.
112
What structural adaptations do pulmonary arteries have?
They have thinner walls and less smooth muscle compared to systemic arteries, allowing for easy expansion during blood flow.
113
What is unique about the pulmonary artery compared to other arteries?
It carries deoxygenated blood instead of oxygenated blood, and its walls are thinner and more elastic.
113
What is the histological structure of pulmonary capillaries?
Composed of a single layer of endothelial cells. Thin walls to facilitate gas exchange. Surrounded by Type I and Type II alveolar cells for oxygen absorption and surfactant production.
114
What is unique about the pulmonary vein compared to other veins?
It carries oxygenated blood instead of deoxygenated blood back to the left atrium.
115
What is hypoxic pulmonary vasoconstriction?
A mechanism where pulmonary arterioles constrict in response to low oxygen levels (hypoxia), diverting blood to better-ventilated areas of the lung.
116
How does pulmonary circulation adapt during exercise?
Pulmonary vessels dilate, and capillary recruitment increases to accommodate the elevated cardiac output.
117
How does the autonomic nervous system influence pulmonary vessels?
Sympathetic stimulation → Mild vasoconstriction Parasympathetic stimulation → Mild vasodilation
118
Where does the aorta originate?
It rises from the left ventricle of the heart.
119
What are the three main sections of the aorta?
Ascending Aorta Aortic Arch Descending Aorta
120
What branches does the ascending aorta give rise to?
Right Coronary Artery Left Coronary Artery
121
What is the main function of the coronary arteries?
They supply oxygenated blood to the heart muscle (myocardium).
122
What are the three main branches of the aortic arch?
Brachiocephalic Trunk → Divides into: Right Subclavian Artery → Supplies the right arm Right Common Carotid Artery → Supplies the right side of the head and neck Left Common Carotid Artery → Supplies the left side of the head and neck Left Subclavian Artery → Supplies the left arm
123
Where is the aortic arch located?
It is located in the superior mediastinum, curving over the left main bronchus and the pulmonary trunk.
124
Into which two sections is the descending aorta divided?
Thoracic Aorta Abdominal Aorta
125
Where does the thoracic aorta extend?
From the aortic arch to the aortic hiatus of the diaphragm.
126
What branches arise from the thoracic aorta?
Parietal Branches → Segmental branches called posterior intercostal arteries (spaces 3–11) Subcostal Artery Superior Phrenic Artery Visceral Branches → Smaller arteries supplying thoracic organs
127
Where does the abdominal aorta begin and end?
It begins at the aortic hiatus of the diaphragm and ends at the L4 vertebral level, where it bifurcates into the common iliac arteries.
128
Where does the external carotid artery arise from?
It arises from the common carotid artery at the level of the fourth cervical vertebra (C4), within the carotid triangle of the neck.
128
What are the visceral branches of the abdominal aorta?
Celiac Trunk → Divides into: Left Gastric Artery Common Hepatic Artery Splenic Artery Superior Mesenteric Artery (SMA) → Supplies midgut structures Inferior Mesenteric Artery (IMA) → Supplies hindgut structures Middle Suprarenal Arteries → Supplies the adrenal glands Renal Arteries → Supplies the kidneys Ovarian/Testicular Arteries → Supplies the gonads
128
What are the parietal branches of the abdominal aorta?
Inferior Phrenic Artery Lumbar Arteries Medial Sacral Artery
129
What is the external carotid artery?
It is a major artery of the head and neck.
129
What is the primary function of the external carotid artery?
To vascularize the external portions of the head and neck.
129
What are the main branches of the external carotid artery?
Superior Thyroid Artery → Supplies the thyroid gland Hyoid, Sternocleidomastoid, Superior Laryngeal, Cricothyroid branches Lingual Artery → Supplies the tongue, specifically the Genioglossus muscle Sublingual and Deep Lingual branches Facial Artery → Supplies the superficial face Ascending Palatine, Tonsillar, Submental, Glandular, Inferior Labial, Superior Labial, Lateral Nasal, and Angular (terminal branch) Ascending Pharyngeal Artery → Supplies the pharynx Occipital Artery → Supplies the scalp and occipital bone Posterior Auricular Artery → Supplies the scalp posterior to the auricle and the auricle itself Maxillary Artery → Supplies deep structures of the face 16 branches including Tympanic, Deep Auricular, Meningeal, Deep Temporal, and Infraorbital Superficial Temporal Artery → Supplies the temple and scalp Transverse Facial, Middle Temporal, Anterior Auricular, Frontal, and Parietal branches
130
What is its anatomical course?
It curves backward behind the posterior belly of the digastric muscle and the stylohyoid muscle, entering the space behind the neck of the mandible, where it begins to branch.
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Where does the external carotid artery begin?
It begins at the upper border of the thyroid cartilage.
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What is the internal carotid artery?
It is a major artery of the head and neck that supplies blood to the brain.
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How many segments is the internal carotid artery divided into?
Four segments: Cervical Segment Petrous Segment Cavernous Segment Cerebral Segment
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Where does the cerebral segment of the internal carotid artery begin?
After it perforates the dura mater on the medial side of the anterior clinoid process, the artery passes between the optic nerve and oculomotor nerve.
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Where does the internal carotid artery originate?
It arises from the common carotid artery, which bifurcates into the external and internal carotid arteries at the level of the fourth cervical vertebra (C4) within the carotid triangle of the neck.
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Where is the petrous segment located?
It enters the carotid canal in the petrous part of the temporal bone, ascends, curves forward and medially, and then enters the cranial cavity.
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Where does the cervical segment of the internal carotid artery begin and end?
It begins at the upper border of the thyroid cartilage at the carotid bifurcation and runs upward in front of the transverse processes until it enters the carotid canal in the skull, anterior to the jugular foramen.
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What branches does the petrous segment give off?
Caroticotympanic Arteries → Enters the tympanic cavity and anastomoses with the anterior tympanic branch of the internal maxillary and the stylomastoid artery branch of the posterior auricular. Artery of the Pterygoid Canal → Passes into the pterygoid canal and anastomoses with a branch of the internal maxillary artery.
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What branches arise from the cavernous segment?
Cavernous Arteries → Supply the hypophysis, semilunar ganglion, and the walls of the cavernous and inferior petrosal sinus. Hypophyseal Arteries → Small vessels supplying the hypophysis. Semilunar Arteries → Small vessels supplying the semilunar ganglion. Anterior Meningeal Arteries → Pass over the wing of the sphenoid to supply the dura mater of the anterior cranial fossa.
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Where is the cavernous segment located?
It lies between the layers of the dura mater within the cavernous sinus. → It is surrounded by sympathetic nerve filaments.
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What branches arise from the cerebral segment?
Ophthalmic Artery → Enters the orbital cavity through the optic foramen. Divides into frontal and dorsal nasal terminal branches. Anterior Cerebral Artery → Passes above the optic nerve, connects to the anterior communicating artery, and anastomoses with the posterior cerebral arteries. Supplies the medial surface of the cerebral hemisphere. Middle Cerebral Artery → The largest branch of the internal carotid. Travels in the lateral cerebral fissure and supplies the lateral surface of the cerebral hemisphere. Posterior Communicating Artery → Runs backward from the internal carotid and anastomoses with the posterior cerebral artery (branch of the basilar artery). Choroidal Artery → Small artery that enters the inferior horn of the lateral ventricle and ends in the choroid plexus.
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What is the ophthalmic artery?
It is a branch of the internal carotid artery that supplies all the structures of the orbit, as well as parts of the nose, face, and meninges.
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Where does the ophthalmic artery originate?
It arises from the internal carotid artery as it emerges from the cavernous sinus.
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What is the maxillary artery?
It is the larger of the two terminal branches of the external carotid artery, arising behind the neck of the mandible.
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What are the main branches of the ophthalmic artery?
Central Artery of the Retina First branch of the ophthalmic artery. Turns superiorly, penetrates the optic nerve, and enters the eye to supply the inner retinal layers. Lacrimal Artery One of the largest branches. Branches as the ophthalmic artery enters the orbit. Supplies the lacrimal gland, eyelids, and conjunctiva. Posterior Ciliary Arteries Typically 1 to 5 arteries that perforate the sclera near the optic nerve. Two types: Long Posterior Ciliary Arteries → Supply the ciliary body and iris. Short Posterior Ciliary Arteries → Supply the choroid and optic disc. Muscular Branches Supply the extraocular muscles of the eye. Supraorbital Artery Passes over the optic nerve, through the supraorbital foramen. Supplies the muscles and skin of the forehead. Ethmoidal Arteries Posterior Ethmoidal Artery → Enters the nose via the posterior ethmoidal canal, supplies the posterior ethmoidal sinuses. Anterior Ethmoidal Artery → Supplies the anterior ethmoidal sinuses and parts of the nasal cavity. Both contribute to the meningeal supply.
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What are the terminal branches of the ophthalmic artery?
Supratrochlear Artery Supplies the forehead and scalp. Dorsal Nasal Artery Supplies the forehead and scalp and anastomoses with the angular artery.
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What are the three main segments of the maxillary artery?
Mandibular Part → Winds around the neck of the mandible. Pterygoid Part → Travels between the two heads of the lateral pterygoid muscle. Pterygopalatine Part → Located in the pterygoid fossa.
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Where does the maxillary artery travel?
Initially imbedded in the parotid gland. Passes between the ramus of the mandible and the sphenomandibular ligament. Travels between the two heads of the pterygoid muscle into the pterygoid fossa, where it gives off its terminal branches.
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What branches arise from the mandibular part of the maxillary artery?
Deep Auricular Artery Supplies the external acoustic meatus. Anterior Tympanic Artery Courses near the tympanic membrane, passes through the petrotympanic fissure to supply the middle ear. Middle Meningeal Artery Passes through the foramen spinosum, supplies the skull and dura mater. Inferior Alveolar Artery Runs with the inferior alveolar nerve; supplies the pulps of teeth and mandible. Mental branch → Supplies the lip and skin in the mental region. Accessory Meningeal Artery Supplies the trigeminal ganglion and dura mater of the middle cranial fossa. Passes through the foramen ovale.
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What branches arise from the pterygopalatine part of the maxillary artery?
Sphenopalatine Artery Supplies the nasal cavity through the sphenopalatine foramen. Descending Palatine Artery Divides into greater and lesser palatine arteries, supplying the hard and soft palate. Travels through the greater palatine canal with branches of the pterygopalatine ganglion. Infraorbital Artery Passes through the inferior orbital fissure and emerges with the infraorbital nerve on the face. Posterior Superior Alveolar Artery Supplies the maxillary teeth and posterior wall of the maxilla. Middle Superior Alveolar Artery Supplies the pharynx and the roof of the nose. Artery of the Pterygoid Canal
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What branches arise from the pterygoid part of the maxillary artery?
Masseteric Artery Runs with the lingual nerve and supplies the masseter muscle. Pterygoid Artery Supplies the lateral and medial pterygoid muscles. Deep Temporal Artery Divides into anterior and posterior branches, supplying the temporalis muscle. Communicates with the lacrimal artery and perforates the zygomatic bone. Buccinator Artery Supplies the buccinator muscle; anastomoses with the infraorbital artery.
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What are the subclavian arteries?
They are paired major arteries of the thorax, located just below the clavicle.
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Where do the subclavian arteries originate?
Right Subclavian Artery → Branches from the brachiocephalic trunk, which is a branch of the aortic arch. Left Subclavian Artery → Comes directly off the aortic arch.
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What are the branches of the thoracic region of the subclavian artery?
Vertebral Artery Ascends to the transverse foramen of C6 Continues through the foramina of C1 to C6 Enters the foramen magnum to supply the brainstem and anastomose with the internal carotid. Internal Thoracic Artery Descends behind the sternum and costal cage. Branches into: Superior Epigastric Artery → Supplies the anterior abdominal wall and part of the diaphragm. Pericardiophrenic Artery → Supplies the pericardium. Musculophrenic Artery → Supplies the diaphragm. Thyrocervical Trunk Ascends and gives off four branches: Suprascapular Artery → Supplies supraspinatus, sternocleidomastoid, and subclavius. Transverse Cervical Artery → Supplies the trapezius and sternocleidomastoid. Inferior Thyroid Artery → Supplies the thyroid gland. Ascending Cervical Artery → Anastomoses with the ascending pharyngeal and occipital arteries.
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What are the three sections of the subclavian artery?
Thoracic Region → Medial to the scalenus anterior muscle Muscular Region → Behind the anterior scalene muscle Cervical Region → Lateral to the scalene muscle but before crossing the first rib
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How does the subclavian artery travel?
It passes between the anterior and middle scalene muscles. → This is different from the subclavian vein, which is anterior to the anterior scalene.
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When does the subclavian artery become the axillary artery?
When it crosses the lateral border of the first rib.
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What are the branches of the muscular region of the subclavian artery?
Costocervical Trunk Divides into: Supreme Intercostal Artery → Supplies the upper two intercostal spaces, deep neck, back skin, and vertebral canal. Deep Cervical Artery → Supplies the deep neck musculature.
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Are there any branches in the cervical region of the subclavian artery?
No, the cervical region does not give off any branches.
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What is the axillary artery?
It is the continuation of the subclavian artery that travels through the axilla and supplies the upper limb, as well as musculocutaneous elements of the scapula and upper thorax.
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Where does the axillary artery begin?
It begins at the outer border of the first rib as a continuation of the subclavian artery.
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What neurovascular structure accompanies the axillary artery?
It sits within a neurovascular bundle formed by the artery and the cords of the brachial plexus, enclosed by the axillary fascia.
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How is the axillary artery divided?
It is divided into three segments by the pectoralis minor muscle: First Segment → 1 branch Second Segment → 2 branches Third Segment → 3 branches
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What does the axillary artery become at the inferior border of teres major?
It becomes the brachial artery.
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What are the six main branches of the axillary artery?
Mnemonic: Some Australian Llamas Support Australian Proletarians Superior Thoracic Artery → Supplies the first two intercostal spaces and upper part of the serratus anterior. Acromiothoracic Artery → Supplies the pectoralis muscles, deltoid, and clavicle region. Lateral Thoracic Artery → Supplies the lateral chest wall and mammary glands. Subscapular Artery → Supplies the subscapularis muscle, teres major, and latissimus dorsi. Anterior Circumflex Humeral Artery → Wraps around the surgical neck of the humerus. Posterior Circumflex Humeral Artery → Larger than the anterior, supplies the deltoid, teres minor, and glenohumeral joint.
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What is the brachial artery?
It is the continuation of the axillary artery after the inferior border of teres major.
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Where does the brachial artery end, and what does it divide into?
It ends at the popliteal fossa at the elbow, where it bifurcates into the radial and ulnar arteries
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Where does the brachial artery travel?
It travels along the brachial region, running with the median nerve and brachial vein.
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What is the main role of the brachial artery?
It supplies blood to the brachial region and maintains a superficial course just beneath the deep fascia.
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What are the branches of the brachial artery?
Profunda Brachii Artery (Deep Brachial Artery) Passes posteriorly to supply the posterior arm. Terminates in radial and middle collateral arteries that anastomose with ulnar collateral arteries. Humeral Nutrient Artery Supplies the humerus. Superior Ulnar Collateral Artery Runs along the ulnar nerve and supplies the elbow joint. Inferior Ulnar Collateral Artery Assists in vascularization of the elbow region. Terminal Branches → Radial Artery and Ulnar Artery Radial → Supplies the lateral forearm and hand. Ulnar → Supplies the medial forearm and hand.
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What is the radial artery?
It is the main artery of the lateral aspect of the forearm, arising from the bifurcation of the brachial artery in the cubital fossa.
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Where does the radial artery travel?
It runs along the anterior portion of the radius, beneath the brachioradialis. At the distal forearm, it lies lateral to the flexor carpi radialis tendon. It winds around the lateral aspect of the radius near the wrist. Crosses the floor of the anatomical snuff box and passes through the heads of the first dorsal interosseous muscle.
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What are the branches of the radial artery?
Radial Recurrent Artery Travels superiorly to anastomose with the radial collateral artery around the elbow joint. Palmar Carpal Branch Near the border of pronator quadratus. Runs across the wrist and anastomoses with the palmar carpal branch of the ulnar artery to supply the carpal bones and joints. Superficial Palmar Branch Passes through the thenar muscles (medial) and anastomoses with the superficial palmar arch. Supplies the thumb and lateral part of the index finger (1½ digits). Deep Palmar Branch Contributes to the deep palmar arch.
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What is the ulnar artery?
It is the main artery of the medial aspect of the forearm, arising from the bifurcation of the brachial artery in the cubital fossa.
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Where does the ulnar artery travel?
It descends along the anteromedial part of the forearm, running deep to the flexor digitorum superficialis, pronator teres, and flexor carpi radialis. It lies on top of brachialis and flexor digitorum profundus. Passes superficially to the transverse carpal ligament, not part of the carpal tunnel. Travels through Guyon's Canal alongside the ulnar vein and ulnar nerve.
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What structures form Guyon's Canal?
Roof → Superficial palmar carpal ligament Medial Border → Pisiform Lateral Border → Hamate Floor → Pisohamate ligament
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What are the proximal branches of the ulnar artery?
Anterior Ulnar Recurrent Artery → Anastomoses with the ulnar collateral branch of the deep brachial artery. Posterior Ulnar Recurrent Artery → Also anastomoses with the ulnar collateral near the elbow joint. Common Interosseous Artery → Divides into: Anterior Interosseous Artery → Descends and anastomoses with the dorsal interosseous artery. Posterior Interosseous Artery → Passes back through the oblique cord and upper border of the interosseous membrane. Anastomoses with the dorsal carpal network.
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What are the distal branches of the ulnar artery?
Palmar Carpal Branch Contributes to the superficial palmar arch. Dorsal Carpal Artery Terminal branch that contributes to the deep palmar arch.
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What does the superficial palmar arch give rise to?
It gives off three common palmar digital arteries, which then branch into proper palmar digital arteries to supply the medial 3½ digits.
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Where is the deep palmar arch located?
It is found at the base of the metacarpals.
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What branches arise from the deep palmar arch?
It gives off 3 or 4 palmar metacarpal arteries that supply the lateral 1½ digits.
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What is the aortic arch?
It is the portion of the main artery that leaves the heart and is located between the ascending and descending aorta.
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Where does the ascending aorta originate?
It leaves the left ventricle of the heart at the level of the third costal cartilage, behind the left half of the sternum.
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What is the path of the aortic arch?
It passes upward, forward, and to the right, then at the second right costal cartilage it enters the mediastinum. The arch travels upward, backward, and to the left, crossing in front of the trachea. It can ascend as high as the midlevel of the manubrium of the sternum
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What is the normal diameter of the aortic arch?
Approximately 30 mm.
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What are the three main branches of the aortic arch?
Brachiocephalic Trunk First and largest branch. Travels to the right and anterior of the other branches. Divides into the Right Common Carotid and Right Subclavian Artery. Left Common Carotid Artery Ascends along the left side of the trachea through the superior mediastinum. Splits into the internal and external carotid arteries. Left Subclavian Artery Ascends through the superior mediastinum along with the left common carotid artery. Moves laterally to supply the left upper limb
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What is the thoracic aorta?
It is the continuation of the descending aorta located within the thorax, contained in the posterior mediastinal cavity.
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Where does the thoracic aorta begin and end?
It begins at the lower border of T4, where the aortic arch ends, and continues until the aortic hiatus of the diaphragm, where it becomes the abdominal aorta.
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What is the approximate diameter of the thoracic aorta?
Approximately 1.1 cm (11 mm) in radius.
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What anatomical structures surround the thoracic aorta?
Posteriorly: Vertebral column and hemiazygos vein To the right: Azygos vein and thoracic duct To the left: Left pleura and lung Anteriorly: Root of the left lung, pericardium, esophagus, and diaphragm
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What are the main branches of the thoracic aorta?
Mnemonic: Ben Made Every Person Suffer Bronchial Arteries → Supply the bronchi. Mediastinal Arteries → Supply the lymph glands and areolar tissue in the posterior mediastinum. Esophageal Arteries → 4–5 branches arise from the front of the aorta to supply the esophagus. Pericardial Arteries → Supply the pericardium. Superior Phrenic Arteries → Supply the diaphragm.
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What additional branches arise along the posterior aspect of the thoracic aorta?
Posterior Intercostal Arteries → These branch off throughout the length of the thoracic aorta and supply the intercostal spaces.
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What is the abdominal aorta?
It is the largest vessel in the abdominal cavity, a continuation of the descending thoracic aorta.
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Where does the abdominal aorta begin and end?
It begins at the aortic hiatus of the diaphragm (T12) and ends at the level of L4, where it bifurcates into the left and right common iliac arteries.
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What is the anatomical path of the abdominal aorta?
It travels down the posterior wall of the abdomen, directly anterior to the vertebral column, following the convex curvature of the lumbar vertebrae.
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What is its relation to the inferior vena cava (IVC)?
The abdominal aorta runs parallel to the IVC, which is positioned to its right.
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What are the two main segments of the abdominal aorta?
Paravisceral Segment → Where the visceral branches arise. Infrarenal Segment → No branches arise from this segment.
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What are the common iliac arteries?
They are the paired terminal branches of the abdominal aorta, arising from the aortic bifurcation at the level of L4.
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What are the paired branches of the abdominal aorta?
Inferior Phrenic Arteries Arise just below the aortic hiatus. Supply the diaphragm and adrenal glands (superior suprarenal arteries). Middle Suprarenal Arteries Arise at the level of L1. Supply the adrenal glands. Renal Arteries Arise at the level of L1-L2. Supply the kidneys. Right renal artery is longer and passes behind the IVC. Gonadal Arteries Arise at the level of L2. In males → Testicular arteries → Supply the testes. In females → Ovarian arteries → Supply the ovaries. Lumbar Arteries Typically four pairs, arise from the posterior surface of the aorta. Supply the lumbar vertebrae, spinal cord, and back muscles.
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What are the unpaired branches of the abdominal aorta?
Celiac Trunk (T12 Level) Left Gastric Artery → Supplies the stomach and esophagus. Splenic Artery → Supplies the spleen, pancreas, and stomach. Common Hepatic Artery → Divides into the proper hepatic artery and gastroduodenal artery, supplying the liver, gallbladder, and parts of the stomach and duodenum. Superior Mesenteric Artery (SMA) (L1 Level) Arises just below the celiac trunk. Supplies the midgut → Small intestine, cecum, ascending colon, and proximal two-thirds of the transverse colon. Major branches include: Inferior Pancreaticoduodenal Artery Jejunal and Ileal Arteries Ileocolic Artery Right Colic Artery Middle Colic Artery Inferior Mesenteric Artery (IMA) (L3 Level) Arises inferior to the SMA. Supplies the hindgut → Distal third of the transverse colon, descending colon, sigmoid colon, and rectum. Major branches include: Left Colic Artery Sigmoid Arteries Superior Rectal Artery
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What clinical conditions are associated with the abdominal aorta?
Abdominal Aortic Aneurysm (AAA) → A dangerous dilation of the abdominal aorta, often occurring below the renal arteries. Atherosclerosis → Can lead to stenosis or occlusion of the branches of the abdominal aorta. Renal Artery Stenosis → Narrowing of the renal arteries, leading to hypertension.
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What is the course of the common iliac arteries?
They run along the medial border of the psoas muscles for about 4 cm, along with the common iliac veins, which are located posteriorly to the right.
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Where do the common iliac arteries terminate?
They end in front of the sacroiliac joint, where they bifurcate into the internal iliac artery and external iliac artery.
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What is the main function of the common iliac arteries?
They supply all blood to the lower limbs and pelvic organs.
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What is the internal iliac artery?
It is a paired artery that supplies the pelvis, buttocks, reproductive organs, and the medial part of the thigh.
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What is the anatomical path of the internal iliac artery?
It is 3–4 cm long. After bifurcation from the common iliac artery, it descends to the upper margin of the greater sciatic foramen. It divides into anterior and posterior trunks. It is located posterior to the ureter, anterior to the internal iliac vein, and runs between the external iliac vein and psoas major muscle.
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What are the main branches of the internal iliac artery?
It is divided into Posterior Division and Anterior Division.
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What branches arise from the posterior division of the internal iliac artery?
Iliolumbar Artery Divides into lumbar and iliac branches. Supplies psoas major, quadratus lumborum, and iliacus. Lateral Sacral Arteries Divided into superior and inferior branches. Pass through the anterior sacral foramina. Supply the dorsum of the sacrum and spinal meninges. Anastomose with gluteal arteries. Superior Gluteal Artery Passes through the greater sciatic foramen. Supplies the gluteal muscles.
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What is the external iliac artery?
It is the continuation of the common iliac artery that travels along the anterior and inferior of the psoas major muscle after the bifurcation of the common iliac artery.
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What branches arise from the anterior division of the internal iliac artery?
Obturator Artery Divides into anterior and posterior branches. Travels through the obturator canal. Supplies the obturator externus, medial thigh, and femur. Inferior Gluteal Artery Supplies the gluteus maximus, piriformis, and quadratus femoris muscles. Umbilical Artery Gives rise to the artery to the vas deferens and the superior vesical artery. In males → Supplies the vas deferens. In females → Forms part of the medial umbilical ligament after birth. Vaginal Artery / Inferior Vesical Artery Vaginal artery → Supplies the vagina. Inferior vesical artery → Supplies the base of the bladder. Middle Rectal Artery Supplies the rectum. Internal Pudendal Artery Exits through the greater sciatic foramen and re-enters through the lesser sciatic foramen. Major branches: Inferior Rectal Artery → Supplies the anal canal. Perineal Artery → Supplies the perineum. Posterior Labial/Scrotal Arteries → Supply the labia/scrotum. Artery to Bulb of Vestibule/Penis → Supplies the bulb of the vestibule or penis. Dorsal Artery of Clitoris/Penis → Supplies the dorsal part of the clitoris or penis. Deep Artery of Clitoris/Penis → Supplies the corpus cavernosum of the clitoris or penis.
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What is the path of the external iliac artery?
It runs posterior and inferior to the inguinal ligament. After it passes the inguinal ligament, it becomes the femoral artery.
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What are the main branches of the external iliac artery?
Inferior Epigastric Artery Anastomoses with the superior epigastric artery and supplies the anterior abdominal wall. Deep Circumflex Iliac Artery Runs along the inguinal ligament to supply the iliac region. Femoral Artery (Terminal Branch) It is the continuation of the external iliac artery after passing beneath the inguinal ligament.
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What is the femoral artery?
It is the main artery of the thigh and the continuation of the external iliac artery after it passes under the inguinal ligament.
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Where does the femoral artery travel?
It enters the thigh from behind the inguinal ligament. It is sheathed in the femoral sheath with the femoral vein. Runs behind the sartorius muscle and medially to the femoral nerve. It supplies the anterior compartment of the thigh.
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What are the main branches of the femoral artery?
Superficial Circumflex Iliac Artery Runs towards the anterior superior iliac spine. Supplies the superficial region of the lower abdominal wall. Superficial Epigastric Artery Travels towards the umbilicus (belly button region). Supplies the superficial fascia and skin of the lower abdomen. Superficial External Pudendal Artery Supplies the skin of the scrotum (males) or labium majus (females). Deep External Pudendal Artery Also supplies the skin of the scrotum (males) or labium majus (females). Travels deeper than the superficial external pudendal. Profunda Femoris (Deep Artery of the Thigh) Arises 4 cm below the inguinal ligament. Enters the medial fascial compartment of the thigh. Supplies the muscle compartments of the thigh. Gives off the following important branches: Lateral Circumflex Femoral Artery → Supplies the lateral thigh muscles. Medial Circumflex Femoral Artery → Supplies the hip joint and adductors of the thigh. Perforating Arteries → Pierce the adductor magnus to supply the posterior compartment of the thigh. Descending Genicular Artery Supplies the knee joint. Participates in the genicular anastomosis around the knee.
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What is the popliteal artery?
It is the continuation of the femoral artery after it passes through the adductor hiatus (a gap in the adductor magnus muscle).
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Where does the popliteal artery travel?
It passes through the popliteal fossa, which is the diamond-shaped space behind the knee joint. It runs close to the joint capsule of the knee. It ends at the lower border of the popliteus muscle, where it branches into the anterior and posterior tibial arteries.
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What are the main branches of the popliteal artery?
Five Genicular Arteries → Form the genicular anastomosis that supplies the knee joint: Superior Lateral Genicular Artery Superior Medial Genicular Artery Middle Genicular Artery Inferior Lateral Genicular Artery Inferior Medial Genicular Artery Sural Arteries Two large branches that supply the gastrocnemius, soleus, and plantaris muscles.
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What are the two main branches of the popliteal artery in the leg?
Anterior Tibial Artery Branches off at the lower border of the popliteus muscle. Travels anteriorly through the interosseous membrane. Runs along the anterior compartment of the leg. Continues as the Dorsalis Pedis Artery on the dorsum of the foot. Posterior Tibial Artery Travels posteriorly through the deep compartment of the leg. Runs alongside the tibial nerve. Passes through the tarsal tunnel into the sole of the foot. Divides into the Medial Plantar Artery and Lateral Plantar Artery.
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What is the Dorsalis Pedis Artery?
It is the continuation of the anterior tibial artery as it enters the foot.
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Where does the Dorsalis Pedis Artery travel?
It passes over the dorsal aspect of the tarsal bones. Moves inferiorly and divides into: First Dorsal Metatarsal Artery → Supplies the first metatarsal region. Deep Plantar Artery → Anastomoses with the lateral plantar artery to form the deep plantar arch.
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What is the role of the posterior tibial artery in the foot?
It supplies the plantar side of the foot. Passes through the tarsal tunnel (behind the medial malleolus). Divides into: Medial Plantar Artery → Supplies the medial plantar region. Lateral Plantar Artery → Supplies the lateral plantar region. Contributes to the deep plantar arch.
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What forms the deep plantar arch?
It is formed by the deep plantar artery (from Dorsalis Pedis) and the lateral plantar artery (from Posterior Tibial).
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What is the significance of the deep plantar arch?
It provides collateral circulation for the metatarsals and toes.
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What is the superior vena cava?
It is the main vein that returns venous blood from the upper half of the body to the right atrium of the heart.
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What is the diameter of the superior vena cava?
Approximately 24 mm.
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What regions of the body drain into the superior vena cava?
The head, neck, and arms.
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Where is the superior vena cava located?
In the anterior right part of the superior mediastinum.
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How is the superior vena cava formed?
By the union of the left and right brachiocephalic veins.
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What forms the brachiocephalic veins?
The jugular vein (from the head) and the subclavian vein (from the arm).
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What veins drain into the brachiocephalic veins?
Internal Thoracic Vein Inferior Thyroid Vein Left Superior Intercostal Vein
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What veins drain the brain and meninges?
The dural venous sinuses.
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What are the dural venous sinuses?
They are spaces between the periosteal and meningeal layers of dura mater that collect venous blood from the brain and skull.
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Where do the dural venous sinuses drain?
They ultimately drain into the internal jugular vein.
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How is venous blood drained from the scalp and face?
By veins that are synonymous with the arteries in those regions. These veins then drain into the jugular veins.
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What are the three main jugular veins?
External Jugular Vein Internal Jugular Vein Anterior Jugular Vein
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How is the external jugular vein formed?
By the union of the posterior auricular vein (drains the scalp) and the retromandibular vein (drains the face) at the angle of the mandible.
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Where does the external jugular vein drain?
It passes underneath the clavicle and drains into the subclavian vein.
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Where does the internal jugular vein begin?
It begins in the cranial cavity as a continuation of the sigmoid sinus, known as the superior bulb.
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Through which foramen does the internal jugular vein exit the skull?
It exits via the jugular foramen.
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How does the internal jugular vein descend?
It descends through the carotid sheath, forming the inferior bulb before joining the subclavian vein.
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What do the anterior jugular veins drain?
They drain the anterior part of the neck.
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Which veins drain into the internal jugular vein?
Facial Vein Lingual Vein Occipital Vein Superior Thyroid Vein Middle Thyroid Vein
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How do the anterior jugular veins connect?
They communicate via the venous arch.
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Where do the anterior jugular veins empty?
They empty into the subclavian vein.
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How is the anterior aspect of the thorax drained?
By the internal thoracic vein, which drains into the brachiocephalic vein.
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How is the posterior aspect of the thorax drained?
By the azygos system, which drains into the Superior Vena Cava (SVC).
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How are the intercostal spaces drained?
The 1st intercostal space → Drained by the highest intercostal vein into the brachiocephalic vein. Right side (2nd–12th) → Drained by the azygos vein into the SVC. Left side (lower thorax) → Drained by the hemiazygos vein. Left side (upper thorax) → Drained by the accessory hemiazygos vein.
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What is the azygos vein?
A large vein running up the right side of the thoracic vertebral column.
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What does the azygos vein drain?
It drains the posterior walls of the thorax and abdomen into the SVC.
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How is the azygos vein formed?
By the union of the ascending lumbar veins and the right subcostal vein.
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What is the hemiazygos vein?
It is the left-sided counterpart to the azygos vein, draining the lower thorax.
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Where does the hemiazygos vein drain?
It drains into the azygos vein at the level of T9.
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What is the accessory hemiazygos vein?
It is a vein on the left side that drains the 5th to 8th intercostal spaces.
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Where does the accessory hemiazygos vein drain?
It drains into the azygos vein or directly into the superior intercostal vein.
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What is the role of the internal thoracic vein?
It collects blood from the superior epigastric vein and drains into the brachiocephalic vein.
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How is the vertebral column drained?
By venous plexuses that run along the column both inside and outside the canal. These are known as the internal vertebral plexus and the external vertebral plexus.
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Where are the spinal veins located?
They are found in the pia mater of the spinal cord.
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What are the two main types of spinal veins?
Two Median Longitudinal Veins → Anterior and Posterior. Two Pairs of Lateral Veins → These enter the vertebral column with the nerve roots.
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How do the longitudinal channels drain?
They drain into the internal vertebral plexus in the epidural space, which then empties into the azygos system in the thorax.
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What are the basivertebral veins?
They are veins that perforate into the body of the vertebrae itself, draining into the internal vertebral plexus.
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What is the inferior vena cava?
It is the largest vein in the body, carrying venous blood from the lower part of the body into the right atrium of the heart.
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How is the inferior vena cava formed?
It is formed by the joining of the left and right common iliac veins at the 5th lumbar vertebra (L5).
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What is the anatomical path of the inferior vena cava?
It is located retroperitoneally in the abdominal cavity, running alongside the right side of the vertebral column. It passes through the diaphragm at the caval opening (T8 level).
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What are the main tributaries of the inferior vena cava?
L5 Level: Common Iliac Veins → Drain the pelvis and lower limbs. L1 to L5 Levels: Lumbar Veins → Drain the posterior abdominal wall. L2 Level: Right Gonadal Vein → Drains the right testicle (testicular vein) or right ovary (ovarian vein). L1 Level: Right Suprarenal Vein → Drains the right adrenal gland. Renal Veins → Drain the kidneys. The left renal vein receives the left gonadal vein and left suprarenal vein before joining the IVC. T8 Level: Hepatic Veins → Drain the liver. Inferior Phrenic Veins → Drain the diaphragm.
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What are the three main veins of the pelvis?
External Iliac Vein Continuation of the femoral vein. Begins at the crossing of the inguinal ligament. Receives: Inferior Epigastric Vein Deep Circumflex Vein Internal Iliac Vein Responsible for the majority of pelvic drainage. Formed near the greater sciatic foramen. Tributaries correspond with the branches of the internal iliac artery, draining: Superior and Inferior Gluteal Veins Internal Pudendal Vein Obturator Vein Lateral Sacral Veins Middle Rectal Vein Vesical Veins Uterine and Vaginal Veins Common Iliac Vein Formed at the upper margin of the pubic symphysis by the union of the internal and external iliac veins. Additionally receives: Iliolumbar Vein Middle Sacral Vein
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How is the posterior abdominal wall drained?
By the lumbar veins, which drain into the IVC.
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How is the anterior abdominal wall drained?
Through a network of veins, including: Superior Epigastric Vein Inferior Epigastric Vein Superficial Epigastric Vein Deep Circumflex Iliac Veins
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Where do these veins drain?
They all feed into the IVC directly or through the external iliac vein.
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What are cava-caval anastomoses?
They are venous connections between the Superior Vena Cava (SVC) and the Inferior Vena Cava (IVC), allowing for collateral circulation if there is an obstruction in either system.
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What is the thoracoepigastric vein?
It is a superficial vein that runs along the lateral aspect of the trunk, connecting the superficial epigastric vein and the lateral thoracic vein.
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What major venous pathways does the thoracoepigastric vein connect?
Axillary Vein → Drains into the SVC (Superior Vena Cava). Femoral Vein → Drains into the IVC (Inferior Vena Cava).
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What is the functional significance of the thoracoepigastric vein?
It establishes a connection between the femoral vein (which drains into the IVC) and the axillary vein (which drains into the SVC), thus creating a cava-caval anastomosis.
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How does the thoracoepigastric vein serve as a portocaval anastomosis?
It is linked to the portal system through the paraumbilical vein, enabling communication between the caval system and the portal venous system.
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Why are these connections important clinically?
They allow venous return if there is a blockage or compression in either the SVC or IVC, providing an alternate route for blood flow.
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What is a portocaval anastomosis?
It is a connection between the portal venous system and the systemic venous system (caval veins).
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How does the thoracoepigastric vein function as a portocaval anastomosis?
It connects with the paraumbilical veins, which are part of the portal system, allowing blood shunting if there is portal hypertension.
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What are the main superficial veins of the upper limb?
Cephalic Vein Runs down the lateral side of the arm and forearm. Drains into the axillary vein. Originates from the dorsal venous network of the hand. Basilic Vein Runs down the medial side of the arm and forearm. Drains into the brachial vein or becomes part of the axillary vein. Originates from the dorsal venous network of the hand. Median Cubital Vein Courses across the crease of the elbow. Connects the cephalic vein and the basilic vein. Common site for venipuncture.
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What superficial venous arches drain the hand?
The dorsal venous arch and palmar venous arch. Both are drained by the cephalic and basilic veins
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How are the superficial veins of the upper limb interlinked?
They are connected by perforating veins along the forearm.
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What are the main deep veins of the upper limb?
Axillary Vein Formed by the basilic vein and brachial veins. Continues as the subclavian vein. Brachial Vein Paired veins that run with the brachial artery. Unite with the basilic vein to form the axillary vein. Radial and Ulnar Veins Run alongside their respective arteries in the forearm. Merge to form the brachial vein.
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What are the main deep veins of the lower limb?
External Iliac Vein Continuation of the femoral vein. Deep Vein of the Thigh (Profunda Femoris Vein) Drains the deep structures of the thigh. Femoral Vein Main deep vein of the thigh, draining into the external iliac vein. Popliteal Vein Formed by the anterior and posterior tibial veins. Located in the popliteal fossa. Fibular (Peroneal) Vein Drains the lateral compartment of the leg. Posterior Tibial Vein Drains the posterior compartment of the leg. Anterior Tibial Vein Drains the anterior compartment of the leg.
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What are the main superficial veins of the lower limb?
Great Saphenous Vein Formed by the dorsal venous arch of the foot and the dorsal vein of the big toe. Runs up the medial side of the leg. Passes anteriorly to the medial malleolus and posterior to the medial condyle of the knee. Drains into the femoral vein just before the inguinal ligament. Small Saphenous Vein Formed by the dorsal venous arch of the foot and the dorsal vein of the little toe. Runs up the posterior aspect of the leg. Drains into the popliteal vein in the popliteal fossa.
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What are the dorsal and plantar venous arches?
They are networks of veins in the foot that drain into the anterior and posterior tibial veins.
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What is the hepatic portal vein?
It is the main vein of the portal system, responsible for transporting venous blood from the digestive tract to the liver for filtering and processing.
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Where does the hepatic portal vein carry blood?
It carries blood from the digestive organs, spleen, pancreas, and gallbladder to the liver.
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What is the purpose of blood passing through the liver?
The liver filters toxins, metabolizes nutrients, and stores vitamins before the blood enters the systemic circulation.
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What veins contribute to the hepatic portal vein?
Splenic Vein → Drains the spleen and receives pancreatic veins. Gastric Vein → Drains the fundus of the stomach. Left Gastro-omental Vein → Drains the curvature of the stomach. Pancreatic Veins → Drain the pancreas. Inferior Mesenteric Vein → Drains the large intestine. Superior Mesenteric Vein → Drains the small intestine and part of the large intestine. Right Gastro-omental Vein → Drains the curvature of the stomach. Anterior and Posterior Inferior Pancreaticoduodenal Veins → Drain the pancreas and duodenum. Jejunal Vein → Drains the jejunum. Ileal Vein → Drains the ileum. Ileocolic Vein → Drains the ileum, colon, and cecum. Right Colic Vein → Drains the ascending colon. Middle Colic Vein → Drains the transverse colon.
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What is a porto-caval anastomosis?
It is a connection between the systemic venous system (caval system) and the portal venous system.
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Why are porto-caval anastomoses important?
They provide collateral circulation if there is an obstruction or portal hypertension in the liver.
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What are the main sites of porto-caval anastomosis?
Esophageal Anastomosis Connection between the esophageal branch of the left gastric vein (portal) and the esophageal branch of the azygos vein (systemic). Rectal Anastomosis Connection between the superior rectal vein (portal) and the middle and inferior rectal veins (systemic). Paraumbilical Anastomosis Connection between the paraumbilical vein (portal) and the superficial epigastric vein (systemic). Often seen as caput medusae during portal hypertension. Retroperitoneal Anastomosis Connection between the splenic vein (portal) and the renal vein (systemic). Intrahepatic Anastomosis Connection between the left branch of the portal vein (portal) and the inferior vena cava (systemic).
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What condition often leads to problems with porto-caval anastomoses?
Liver cirrhosis, which can cause portal hypertension. This leads to enlargement and rupture of the veins at these anastomotic sites, causing varices and potential hemorrhage.
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How can porto-caval anastomoses indicate liver cirrhosis?
They become engorged and visible when the portal pressure increases. Examples include: Esophageal varices → Risk of bleeding. Caput medusae → Distended veins around the umbilicus. Hemorrhoids → Dilated veins in the rectum.
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What is the role of the umbilical cord in fetal circulation?
It receives deoxygenated blood from the iliac arteries of the fetus and returns oxygenated blood from the placenta to the fetus' liver via the inferior vena cava.
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How does oxygenated blood arrive in the fetus?
Through the umbilical vein, carrying oxygen and nutrients from the placenta.
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What happens to the oxygenated blood when it enters the fetus?
One-third of the blood enters the inferior vena cava directly via the ductus venosus. The remaining two-thirds are mixed with deoxygenated blood in the liver before entering the IVC.
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What is the ductus venosus?
A vessel that shunts oxygenated blood from the umbilical vein directly into the inferior vena cava, bypassing the liver.
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How does blood travel through the fetal heart?
Blood from the inferior vena cava enters the right atrium. Blood is shunted directly to the left atrium through the foramen ovale. Blood then enters the left ventricle and is pumped into the aorta for systemic circulation.
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What is the ductus arteriosus?
It is a vessel that connects the pulmonary artery to the aorta, diverting blood away from the non-functioning fetal lungs and into systemic circulation.
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What is the foramen ovale?
It is an opening between the right and left atria in the fetal heart, allowing blood to bypass the lungs.
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Why is the ductus arteriosus important in fetal circulation?
It allows most of the blood from the right ventricle to bypass the lungs and enter the aorta, since the lungs are not used for oxygen exchange in the fetus.
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What triggers the changes in fetal circulation at birth?
The initiation of breathing expands the lungs and reduces capillary resistance, allowing blood flow through the pulmonary capillaries.
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What happens to blood in the descending aorta?
It enters the umbilical arteries, which return deoxygenated blood back to the placenta for re-oxygenation.
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What happens to the foramen ovale at birth?
The pressure in the right atrium drops due to lung expansion, causing the foramen ovale to close, eventually forming the fossa ovalis.
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What change occurs to the ductus arteriosus after birth?
Increased aortic pressure reverses blood flow, leading to its closure. It gradually becomes the ligamentum arteriosum after a few months.
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What happens to the umbilical vein after birth?
When the umbilical cord is cut, the umbilical vein closes and becomes the ligamentum teres hepatis in the liver.
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Summary of Fetal Structures and Adult Remnants
Fetal Structure Function Adult Remnant Ductus Venosus Shunts blood from the umbilical vein to IVC Ligamentum Venosum Foramen Ovale Shunts blood from right to left atrium Fossa Ovalis Ductus Arteriosus Shunts blood from pulmonary artery to aorta Ligamentum Arteriosum Umbilical Vein Carries oxygenated blood from placenta Ligamentum Teres Hepatis Umbilical Arteries Carry deoxygenated blood to placenta Medial Umbilical Ligaments
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What is the lymphatic system?
It is a network of tissues and organs that helps the body remove toxins and unwanted materials. It plays a major role in immune defense and fluid balance.
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What is the primary function of the lymphatic system?
To transport lymph, a fluid rich in white blood cells (lymphocytes), throughout the body.
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What are the main components of the lymphatic system?
Lymph Vessels → Transport lymph fluid. Lymph Nodes → Filter lymph and monitor for pathogens. Lymphoid Organs → Include the tonsils, thymus, and spleen.
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What is the role of lymph nodes?
They filter lymph, trap pathogens, and facilitate immune responses.
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What are the main lymphoid organs?
Tonsils → Trap pathogens entering through the mouth and nose. Thymus → Site of T-cell maturation. Spleen → Filters blood, removes old red blood cells, and responds to infections.
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How do lymphatic vessels collect fluid?
They collect interstitial fluid from tissues and transport it as lymph. Approximately 3 liters of interstitial fluid is collected each day.
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What is the structure of lymphatic capillaries?
Made of loosely overlapping endothelial cells. Allow fluid to move in but not out. Work similarly to veins, with a thin layer of smooth muscle and valves to prevent backflow.
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How does lymph move through the vessels?
Lymph is propelled through: Skeletal muscle contraction Smooth muscle action in the vessel walls Respiratory movements
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What are the two main lymphatic ducts?
Right Lymphatic Duct Collects lymph from the right arm, right side of the head, and right thorax. Drains into the right subclavian vein. Thoracic Duct Collects lymph from the left side of the head, left arm, left thorax, and entire lower body. Drains into the left subclavian vein.
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What is the cisterna chyli?
It is a large lymphatic sac located at the L1-L2 vertebral level that collects lymph from the intestinal and lumbar trunks before it enters the thoracic duct.
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Pathway of Lymph Flow
1️⃣ Interstitial Fluid → Collected by Lymph Capillaries 2️⃣ Lymph Capillaries → Drain into Lymph Vessels 3️⃣ Lymph Vessels → Transport fluid to Lymph Nodes for filtration 4️⃣ Lymph Nodes → Clean lymph and send it forward 5️⃣ Lymphatic Ducts → Right Lymphatic Duct or Thoracic Duct 6️⃣ Subclavian Veins → Lymph re-enters the bloodstream
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What are lymph nodes?
They are small, ovoid structures found throughout the body, functioning as filters for lymphatic fluid and immune response centers.
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How many types of tonsils are there?
Five main types: Adenoid Tonsil (Pharyngeal Tonsil) Tubal Tonsils (2 - one on each side) Palatine Tonsils (2 - one on each side of the throat) Lingual Tonsil
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How many lymph nodes are present in the human body?
Approximately 600 lymph nodes.
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What types of cells are predominantly found in lymph nodes?
T lymphocytes (T cells), B lymphocytes (B cells), macrophages, and plasma cells.
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Where are the main clusters of lymph nodes located?
Underarms (axillary) Groin (inguinal) Neck (cervical) Chest (thoracic) Abdomen
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What are the two main regions of the lymph node?
Outer Cortex Inner Medulla
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What is the size and structure of a lymph node?
Up to 1 cm long. Surrounded by a fibrous capsule. Contains trabeculae (indentations) that extend inward.
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What is the role of T cells in the cortex?
T cells are found in the inner layer of the cortex, responsible for cell-mediated immune response.
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What does the outer cortex of a lymph node contain?
It contains B cells arranged in follicles.
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What is found in the germinal centers of the cortex?
The germinal centers are sites of B cell proliferation and maturation.
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What cells are predominantly found in the medulla of the lymph node?
Macrophages → Involved in phagocytosis of pathogens. Plasma Cells → Produce antibodies. B Cells → Present in smaller numbers than in the cortex.
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What structures are present in the medulla for lymph flow?
Medullary sinuses, which are spaces for lymph to flow and filter through.
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What is the hilum of a lymph node?
It is the depression where the efferent lymphatic vessel exits the lymph node.
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What is the function of the efferent lymphatic vessel?
It carries filtered lymph away from the lymph node toward venous circulation or another lymph node.
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What are tonsils?
They are masses of lymphoid tissue located around the aerodigestive tract, acting as one of the first lines of defense in the immune response.
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What type of lymphatic tissue are tonsils classified as?
They are part of Mucosa-Associated Lymphatic Tissue (MALTs).
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Where is the adenoid tonsil located?
At the roof of the pharynx.
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What type of epithelium does the adenoid tonsil have?
Respiratory epithelium with small folds.
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Where are the tubal tonsils located?
In the roof of the pharynx, near the opening of the Eustachian tube.
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What type of epithelium do the tubal tonsils have?
Respiratory epithelium.
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Where are the palatine tonsils located?
On either side of the oropharynx, visible at the back of the throat.
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What type of epithelium do the palatine tonsils have?
Non-keratinized stratified squamous epithelium.
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What special feature do the palatine tonsils have?
A network of pits (crypts) that store B cells and trap pathogens.
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Where is the lingual tonsil located?
At the base of the tongue, behind the terminal sulcus.
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What type of epithelium does the lingual tonsil have?
Non-keratinized stratified squamous epithelium.
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What special feature does the lingual tonsil have?
A network of pits (crypts) for capturing antigens and activating B cells.
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What are M cells and what is their role in tonsils?
M cells are specialized epithelial cells that capture antigens and present them to B cells and T cells in the tonsils.
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Where do B cells proliferate in the tonsils?
In the germinal centers of the tonsils.
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What is produced in the germinal centers?
B memory cells → Long-term immunity. Secretory antibodies (mainly IgA) → Local immune defense.
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What is the thymus?
It is both an endocrine gland and a primary lymphoid organ. Plays a crucial role in the development and maturation of T-lymphocytes (T cells).
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What happens to the thymus over a person's lifetime?
It is large and active in children, reaching its maximum size at puberty. After puberty, it atrophies and becomes barely distinguishable in old age.
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What is the size and location of the thymus?
It measures approximately 5 cm x 4 cm x 6 cm. Located in the anterior mediastinum, extending from the fourth costal cartilage to the lower border of the thyroid gland. It overlies the sternum and is positioned above the pericardium.
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What do the lobules consist of?
They are made up of nodules (follicles), each containing a cortex and a medulla.
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What are the main structural components of the thymus?
Two Lateral Lobes → Positioned near the midline. Fibrous Capsule → Each lobe is surrounded by a fibrous capsule. Lobules → Each lobe is divided into lobules by areolar tissue.
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What is the function of the cortex in the thymus?
The cortex is densely packed with immature T cells (thymocytes). These T cells are educated to recognize antigens presented by epithelial cells. Those that respond correctly survive; those that do not are eliminated.
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What is the role of the medulla in the thymus?
T cells migrate from the cortex to the medulla for further testing. In the medulla, they are exposed to self-antigens to test for autoimmunity. Only T cells that do not react to self-antigens are allowed to mature.
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What are Hassall's Corpuscles?
They are eosinophilic structures found in the medulla of the thymus. Composed of type VI epithelial reticular cells. Their exact function is unknown, but they are thought to be involved in T cell maturation or regulation.
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What arteries supply blood to the thymus?
Internal Thoracic Artery Superior Thyroid Artery Inferior Thyroid Artery
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What is the primary function of the thymus?
It trains and develops T-lymphocytes (T cells) to ensure they can: Recognize foreign antigens. Ignore the body's own cells (prevent autoimmunity).
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What is the significance of self-tolerance in T cells?
It prevents the immune system from attacking the body's own tissues, avoiding autoimmune diseases.
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What is the spleen?
It is a lymphatic organ that functions to filter blood, store blood, and protect the body from infections.
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Where is the spleen located?
It is situated in the left hypochondriac region of the abdominal cavity, between the stomach and the diaphragm.
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What is the average size of the spleen?
Approximately 4 inches long.
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How is the spleen vascularized?
It is well-vascularized by the splenic artery, which is a branch of the celiac trunk.
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What are the two main surfaces of the spleen?
Diaphragmatic Surface → Faces the diaphragm. Visceral Surface → Faces the abdominal organs (stomach, left kidney, pancreas).
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What is the hilum of the spleen?
It is the entry and exit site for the splenic artery, splenic vein, and lymphatic vessels.
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What are the borders and poles of the spleen?
Superior Border → Notched and sharp. Inferior Border → Rounded and smooth. Intermediate Border → Separates the diaphragmatic and visceral surfaces. Anterior Pole → Faces the stomach. Posterior Pole → Faces the diaphragm.
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What ligaments attach the spleen to surrounding structures?
Gastrosplenic Ligament → Connects the spleen to the stomach. Splenorenal Ligament → Connects the spleen to the left kidney. Phrenicocolic Ligament → Supports the spleen superiorly, attaching to the diaphragm and colon.
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What is bone marrow?
It is a soft, spongy tissue found in the medullary cavities of bones, responsible for blood cell production (hematopoiesis).
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What are the two main tissue components of the spleen?
White Pulp Contains lymph nodules arranged around a central arteriole called the Malpighian capsule. Composed of B-lymphocytes and T-lymphocytes. Functions in immune response activation (humoral and cell-mediated immunity). Red Pulp Composed of sinuses filled with blood cells, lymphocytes, and macrophages. Functions in phagocytosis of old red blood cells and pathogens.
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How many types of bone marrow are there?
Two types: Red Bone Marrow → Hematopoietic, rich in blood cells. Yellow Bone Marrow → Adipocyte-rich, mostly fat storage, with minimal hematopoiesis.
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What makes red bone marrow red?
The abundance of blood and hemopoietic cells.
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What are the primary functions of the spleen?
Filtration of Blood → Removes old and damaged red blood cells. Immune Response → Activates B and T cells in response to pathogens. Phagocytosis → Carried out by macrophages in the red pulp. Storage of Red Blood Cells (RBCs) → Acts as a reservoir for RBCs. Hematopoiesis during Fetal Development → Produces blood cells during gestation.
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Where is red bone marrow primarily found?
Flat bones → Pelvis, sternum, cranium, ribs, vertebrae, and scapulae. Spongy material at the epiphyseal ends of long bones (like the femur and humerus).
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What cells are found in red bone marrow?
Myelopoietic cells → Develop into granulocytes and monocytes. Erythropoietic cells → Develop into red blood cells (erythrocytes). Other cells → Include plasma cells, reticular cells, lymphocytes, monocytes, and megakaryocytes.
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What are hematopoietic stem cells?
They are multipotent stem cells that give rise to: Leukocytes (white blood cells) Erythrocytes (red blood cells) Platelets
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What makes yellow bone marrow yellow?
The presence of adipocytes (fat cells).
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How does bone marrow change with age?
Red bone marrow is gradually replaced by yellow bone marrow as a person ages.
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Where is yellow bone marrow primarily found?
In the diaphysis (shaft) of long bones.
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What is the stroma of bone marrow?
It is the supportive tissue within the bone marrow that is not directly involved in hematopoiesis.
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What is the structure of the stroma?
It is a meshwork of specialized fibroblastic cells, collagen fibers, and a supportive matrix.
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What makes up the bone marrow matrix?
Similar to bone matrix: Collagen Type I Proteoglycans Fibronectin Laminin
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What is the primary function of bone marrow?
Hematopoiesis → Production of all blood cells (red and white blood cells, and platelets).
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What blood cells are produced directly in the bone marrow?
Granulocytes (Neutrophils, Eosinophils, Basophils) Monocytes Red Blood Cells (Erythrocytes) Platelets (from Megakaryocytes)
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Where are B cells produced and matured?
They are produced in their immature state in the bone marrow and then travel to lymphoid tissues for maturation.
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What are the two main groups of lymph nodes in the head and neck?
Superficial Lymph Nodes → Associated with the external jugular vein. Deep Lymph Nodes → Form a chain along the internal jugular vein.
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What are the main superficial lymph nodes of the head and neck?
Occipital Nodes → Drain the posterior scalp and upper neck. Mastoid Nodes → Also known as retroauricular nodes, drain the posterior auricle and scalp. Both occipital and mastoid nodes drain into superficial nodes along the external jugular vein. Parotid Nodes → Drain the lateral face, eyelids, and parotid gland. Submandibular Nodes → Drain the medial face, upper lip, floor of the mouth, and anterior tongue. Submental Nodes → Drain the lower lip, chin, and tip of the tongue. The parotid, submandibular, and submental nodes drain into the deep jugular nodes along the internal jugular vein.
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Where are the superficial lymph nodes located?
They are positioned along the external jugular vein.
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Where are the deep cervical lymph nodes located?
They form a chain along the internal jugular vein, deep to the sternocleidomastoid muscle.
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What are the two major nodes of the deep cervical chain?
Jugulodigastric Node Located near the posterior belly of the digastric muscle. Drains the tonsils, pharynx, and posterior tongue. Often the first node to swell in tonsillitis. Jugulo-omohyoid Node Located near the intermediate tendon of the omohyoid muscle. Drains the tongue and oral cavity.
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Flow of Lymphatic Drainage in the Head and Neck
1️⃣ Superficial Nodes → Drain into superficial lymphatic vessels along the external jugular vein. 2️⃣ Deep Nodes → Drain into the deep cervical chain along the internal jugular vein. 3️⃣ Deep Cervical Chain → Converges into the jugular lymphatic trunks. 4️⃣ Jugular Lymphatic Trunks → Empty into the thoracic duct (left) and right lymphatic duct (right). 5️⃣ Subclavian Veins → Lymph returns to systemic circulation.
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Where do all lymphatics from the upper limb drain?
They drain into the lymph nodes in the axilla (axillary lymph nodes).
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What other regions drain into the axillary lymph nodes?
Upper back Shoulder Lower neck Chest Upper abdominal wall
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How many lymph nodes are typically found in the axillary region?
Around 20–30 lymph nodes.
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How are the axillary lymph nodes grouped?
🔹 They are divided based on their location and drainage: 1️⃣ Humeral (Lateral) Nodes Located posteromedial to the axillary vein. Receive most of the drainage from the upper limb. 2️⃣ Pectoral (Anterior) Nodes Located along the inferior margin of pectoralis minor. Drain the abdominal wall, chest, and mammary gland. 3️⃣ Subscapular (Posterior) Nodes Found on the posterior axillary wall with subscapular vessels. Drain the back, shoulder, and neck. 4️⃣ Central Nodes Embedded in axillary fat. Receive lymph from the humeral, subscapular, and pectoral nodes. 5️⃣ Apical Nodes The most superior group in the axilla. Drain all other axillary nodes as well as lymph from the cephalic vein and superior region of the mammary gland.
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Where do superficial lymphatic vessels arise?
From the lymphatic plexus on the skin of the hand.
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What veins do the superficial lymphatic vessels follow?
They ascend along with the basilic vein (medial side) and the cephalic vein (lateral side).
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Where do these superficial vessels terminate?
They drain into the apical nodes in the axilla.
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What veins do the deep lymphatic vessels follow?
They follow the deep veins of the upper limb: Radial Vein Ulnar Vein Brachial Vein
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Where do the deep lymphatic vessels terminate?
They drain into the humeral (lateral) axillary lymph nodes.
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How are lymph nodes of the thorax categorized?
They are divided into Parietal Lymph Nodes and Visceral Lymph Nodes.
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What are the main parietal lymph nodes in the thorax?
Parasternal Lymph Nodes Located at the ends of the intercostal spaces, near the internal thoracic artery. Drain into the bronchomediastinal trunk. Intercostal Lymph Nodes Found in the intercostal spaces. Receive deep lymphatics from the postero-lateral chest wall. Drain into the right lymphatic duct (right side) or the thoracic duct (left side). Superior Diaphragmatic Lymph Nodes Receive lymph from the diaphragm, surface of the liver, and connect to lumbar lymph nodes. Divided into anterior, middle, and posterior groups. These typically drain into the thoracic duct.
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What are the main visceral lymph nodes in the thorax?
Tracheobronchial Lymph Nodes Collect lymph from the lungs, bronchi, heart, and trachea. Drain into the bronchomediastinal trunk. Bronchopulmonary (Hilar) Nodes Located at the hilum of the lungs. Drain lymph from the lung parenchyma and bronchi. Paratracheal Nodes Located along the trachea. Collect lymph from the trachea and bronchi. Intrapulmonary Nodes Found within the lung tissue. Drain the alveolar spaces and small bronchioles. Superior and Inferior Tracheobronchial Nodes Positioned at the bifurcation of the trachea. Drain the main bronchi and superior portions of the lung.
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What are the main lymphatic vessels in the thoracic region?
Thoracic Duct The largest lymph vessel in the body. Begins at T12 (cisterna chyli) and extends to the root of the neck. Drains into the left subclavian vein and the left internal jugular vein at the start of the brachiocephalic vein. Collects lymph from both lower limbs, abdomen, left thorax, left arm, left head, and left neck. Right Lymphatic Duct 1.25 cm in length. Runs along the medial border of scalenus anterior at the root of the neck. Drains into the right subclavian vein and right internal jugular vein at the brachiocephalic vein. Collects lymph from the right thorax, right arm, right head, and right neck. Bronchomediastinal Lymph Trunk Formed by the combination of: Tracheobronchial vessels Internal mammary vessels Anterior mediastinal lymph vessels Functions as the collector of lymph from the chest and thoracic wall. Drains into either the right lymphatic duct (right side) or the thoracic duct (left side).
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Flow of Lymph in the Thorax
1️⃣ Visceral and Parietal Nodes → Collect lymph from the lungs, bronchi, heart, diaphragm, and thoracic wall. 2️⃣ Bronchomediastinal Trunk → Collects lymph from thoracic nodes. 3️⃣ Thoracic Duct (left) or Right Lymphatic Duct (right) → Lymph is directed to the venous system. 4️⃣ Subclavian Veins → Lymph enters the circulatory system.
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What are the pelvic lymphatic vessels and lymph nodes?
They are a network of lymph vessels and nodes that drain lymph from the pelvic organs, lower abdominal wall, gluteal region, and lower limbs.
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How are the pelvic lymph nodes classified?
They are classified into: Parietal Lymph Nodes → Drain the pelvic walls. Visceral Lymph Nodes → Drain the pelvic organs.
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What are the main parietal lymph nodes in the pelvis?
External Iliac Lymph Nodes Located along the external iliac vessels. Drain lymph from the lower limbs, lower abdominal wall, and pelvic viscera. Internal Iliac Lymph Nodes Located along the internal iliac vessels. Drain lymph from the pelvic organs, including the bladder, prostate (in males), cervix, and vagina (in females). Common Iliac Lymph Nodes Located along the common iliac vessels. Receive lymph from both external and internal iliac nodes. Transport lymph to the lumbar lymph nodes.
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What are the main visceral lymph nodes in the pelvis?
Perivesical Lymph Nodes Located around the urinary bladder. Drain the bladder wall. Pararectal Lymph Nodes Located near the rectum. Drain the rectal walls and anal canal. Sacral Lymph Nodes Found in the sacral region of the pelvis. Drain the lower rectum, cervix, and sacral soft tissues. Parametrial Lymph Nodes Located in the broad ligament of the uterus (in females). Drain the uterus and cervix.
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What is the pathway of lymphatic drainage in the pelvis?
1️⃣ Visceral and Parietal Lymph Nodes collect lymph from organs and walls. 2️⃣ Lymph is then transported to the internal and external iliac nodes. 3️⃣ These drain into the common iliac nodes. 4️⃣ From the common iliac nodes, lymph is carried to the lumbar (aortic) lymph nodes. 5️⃣ Finally, lymph enters the thoracic duct and returns to venous circulation.
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