Cardiovascular Drugs Flashcards Preview

PATH3190 References > Cardiovascular Drugs > Flashcards

Flashcards in Cardiovascular Drugs Deck (11)
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1
Q

Fyhrquist, 2008

A

There are several more Ang peptides synthesised from I and II: III to VII. III and IV especially have opposing effects to Ang II so act as modulators of the RAAS system

2
Q

Santos, 2003

A

MAS1 is the gene that codes for AT3R which is a GPCR that binds Ang I to VII. This receptor opposes many of the effects of AT1R so agonists of this receptor could be used as a therapeutic for hypertension

3
Q

SOLVD-TREATMENT Trial

A

ACE inhibitors in heart failure

4
Q

CHARM trial

A

ARBs in heart failure

5
Q

RALES trial, 1996

A

Spironolactone in Heart Failure

6
Q

Catterall, 2005

A

Types of voltage gated calcium channel

7
Q

Elliott, 2011

A

Uses of Calcium Channel Blockers

8
Q

Zuccotti, 2011

A

T-type Voltage Gated Calcium Channels-Generate a ‘background current’ -Milbefredil-used as a T-type antagonist for Hypertension and Angina but generated pro-arrhythmic effects

9
Q

PARADIGM Trial, 2013

A

Showed Efficacy of Entresto

10
Q

Nakae, 2000

A

Showed that K+ channel activators were successful in patients resistant to organic nitrates

11
Q

Ortlepp, 2002

A

RAAS Polymorphisms that contribute to cardiovascular Disease:
Angiotensinogen M235T-missense in exon 2
ACE deletion of 287bp at intron 16
AT1R A1166C missense mutation