Carlsson Flashcards
(10 cards)
what is hyperdopaminergia
too much of nt dopamine
what is hypoglutamatergia
too little of nt glutamate
aim of carlsson
review studies that look at relationship between nt & sz
look at effectiveness of drug treatment for sz
method of carlsson
reviewing 32 studies in total, 8 animal, 5 drugs, 12 brain scans, 7 other.
looking at different levels of severity
conducted a review of the studies
results of carlsson
- link between dopamine and sz but varies between patients
- not just dopamine other nt are associated e.g. serotonin, GABA
- low glutamate = high dopamine = sz symptoms
- PCP lowers glutamate which increases psychosis symptoms
- brain areas associated with sz include basal ganglia and cerebral cortex
- clozapine an atypical antipsychotic is very effective and has minimal side effects compared to others
conclusion of carlsson
- clozapine is best so should be used
- dopamine/glutamine are associated with sz but more research needs to be done on other nt
evaluate carlsson in terms of generalisability
:( lots of animal studies not representative of sz in humans
:) uses a variety of studies e.g. animal, brain scans -> more representative of role of nt as looking at lots of settings
evaluate carlsson in terms of reliability
:) secondary data is reliable because it is already published so researcher can go through findings as many times as needed
evaluate carlsson in terms of applications
:) useful as we know which drugs should be prescribed -> clozapine is best which is useful to ensure patient gets best treatment
evaluate carlsson in terms of validity
:( secondary data -> may be biased as researcher may have chosen studies that fit aim
:( temporal validity may be low as published results may use outdated diagnosis manual less valid as wont represent sz today
:( some studies look at parkinsons -> less representative of sz as not directly studying it
