Cartilage Block 1 Flashcards

1
Q

what supports soft tissues and body weight?

A

cartilage and bone

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2
Q

what are the supportive connective tissue

A

cartilage and bone

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3
Q

what is the cartilage matrix made up of

A

proteoglycans
ground substance
chondrocytes

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4
Q

chondrocytes are surrounded by?

A

lacunae

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5
Q

what is a gel-type ground substance and is good for shock absorption and protection

A

cartilage

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6
Q

chondrocytes produce what

A

antiangiogensis factor

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7
Q

that is the outer fibrous layer of cartilage and is good for strength

A

perichondrium

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8
Q

the inner cellular layer that is good for growth and maintenance in cartilage is the

A

perichondrium

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9
Q

what is the skeletal connective tissue that is characterized by firmness and reiliency

A

cartilage

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10
Q

most cartilage is enveloped by dense connective tissue layer called the perichondrim is good for?

A

blood supply

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11
Q

chondrocytes are what shape

A

round, on lightmicroscope

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12
Q

on an EM chondrocytes surface show what

A

projections and infoldings

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13
Q

chondrocyte synthesize and secret what

A

type 2 collagen fibers

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14
Q

where are condrocytes synthesized

A

RER

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15
Q

chondrocyte produce most of their energy by what

A

anaerobic glycolosis ( NEEDS NO O2 TO MAKE ENERGY)

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16
Q

the ground substance of cartilage have what

A
GAG
proteoglycans
proteoglycan aggregates
glycoproteins
tissue fluid
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17
Q

what doe stye firmness of the hyaline cartilage result from

A

the extensive cross linking among its components

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18
Q

what is the potential space occupied by each chondrocyte

A

the lacuna

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19
Q

when is the lacuna visible

A

only after cell death or after shrinkage during tissue processing

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20
Q

what is the matrix that immediately surrounds the chondrocyte

A

territorial matrix (capsular)

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21
Q

all cartilage derives from where

A

embryonic mesenchyme

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22
Q

what happens to mesenchyme cells in development

A

they retract their cytoplasmic extensions and assume a ROUND shape and they become more tightly packed forming MENECHYMAL CONDENSATION

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23
Q

what forms first chondrocyte or chondroblast?

A

chondroblast

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24
Q

what are the two process that cartilage grows by?

A

mitosis and deposition of additional matrix

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25
what is matrix synthesis enhanced by
the growth hormone THYROXINE and testosterone
26
what is thyroxine and testosterone inhibited by
estradiol and cortisol
27
after the age 30 males loose how much testosterone
loose 3% testosterone
28
what is known as the growth hormone
thyroxine
29
what does interstitial growth involve?
the division of existing chondrocytes and it gives rise to ingenious groups
30
what is a side affect of using cortisone
cartilage and tendons
31
what does appositional growth involve
the differentiation into chondrocytes by chondroblasts and stem cells on the perichondrum's inner surface
32
why do we do cartilage transplants from cadavers?
because cartilage is extremely hard to repair
33
what does repair of the cartilage involve?
invasion of the breach of by mesnechymal stem cells from the perichondrium
34
if the gap is really large in cartilage then what
a dense connective tissue scar may form
35
what makes hyaline cartilage an ideal fetal skeletal tissue
because of its ability to grow rapidly while maintaing its ridgitiy
36
what are some examples go hyaline cartilage
costal cartilages, laryngeal cartilages, cartilaginous rings that support the trachea and irregular cartilage plates in the walls of the bronchi
37
which cartilage is yellowish and when fresh is more flexible then hyaline cartilage
elastic cartilage
38
what is the composition of elastic cartilage
it resembles hyaline but contains a dense network of branching elastic fibers
39
where does elastic cartilage develop from
a primitive connective tissue that contain wavy fibril in bundles
40
what secrets elastin
fibroblast
41
what is transformed into elastic fibers
elastin and fibrilin bundles
42
which cartilage provides flexible support
elastic cartilage
43
where is elastic cartilage found
external ear epiglottis larynx
44
what cartilage is intermediate in character between hyaline cartilage and dense CT
fibrocartilage
45
which cartilage is characterized by abundant type 1 collage fibers
fibrocartilage
46
what do we not understand about fibrocartilage
its growth
47
where does fibrocartialge develop
where there is strong mechanical stress
48
fibro cartilage is always associate with what
dense connective tissue
49
the border between fibrocartilage and dense CT
is indistinguishable
50
what allows fibrocartilage to resist deformation under a lot of stress
its combination of cartilaginous ground substance and dense collagen fiber
51
where do you find fibroblast
in the perichondrium
52
where can fibrous cartilage be found in humans
annulus fibrosus intervertible disk symphysis pubis some bone ligaments
53
where do chondrocytes undergo division
in the lacuna
54
in appositional growth what happens to the matrix
it triples in size
55
what produces matrix in appositional growth
the chondrocytes
56
three types of cartilage
hyaline elastic fibrous
57
what cartilage has translucent matrix and no prominent fibers
hyaline cartilage
58
what cartilage reduces friction on joints
hyaline cartilage
59
you can see lacuna in what process
the goring process
60
Herniated disks happens due to
fibrocartilage breaking under pressure
61
what limits movement
fibrocartilage
62
what pads knee joints
fibrocartilage
63
what is found between pubic bones and intervertebral disc
fibrocartilage
64
what prevents bone to bone contact
fibrocartilage