Casus 1 Parkinson

Question 1

What is the primary cause of parkinson?

Answer 1

The degeneration of nigrostriatal neurons that results in lower dopamine concentration in the striatum.

Question 2

Wat zijn de symptomen van parkinson?(4)

Answer 2

Tremor –> pill rolling tremor
Rigidity –> cogwheel(upper)led pipe rigidity(lower)
Akinesia –> struggle to move
Postural instability–> hunched over

Question 3

What is used in pet scans for parkingson and where does it bind?

Answer 3

18Fluordopa binds to the dopamine receptors in the striatum.

Question 4

What is the most used drug to help relieve parkinson symptoms?

Answer 4

L-dopa

Question 5

how does deep brain stimulation work?

Answer 5

An electrode is placed in the subthalamic nucleus to stimulate this part of the brain.

Question 6

what happens to the dopaminergic neurons in Parkingson?

Answer 6

The neurons in the substantie nigra pars compactum degenerate and the remaining ones start to malfunction due to lewis bodies.

Question 7

What is the function of the D1 and D2 receptors in the brain and where are they located?

Answer 7

they lay in the substantia nigra pars compactum:
D1: stimulate movement
D2: inhibit movement

Question 8

What causes the degeneration of the substantia nigra pars compactum

Answer 8

Alpha- Synuclein