CAUSAL INFERENCE Flashcards

(53 cards)

1
Q

statistical dependence between two variables

A

Statistical Association

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2
Q

either positive or negative

A

Statistical Association

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3
Q

process of using statistical methods to characterize the association between variables.

A

Statistical Association

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4
Q

process of ascribing causal relationships to associations between variables

A

Causal Inference

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5
Q

Types of Association

A
  • Causal
  • Noncausal
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6
Q

types of causal

A
  • Direct
  • Indirect
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7
Q

Alteration in the frequency or quality of one event is followed by a change in the other

A

causal

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8
Q

Association is a result of the relationship of both factor and disease with a third variable

A

non-causal

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9
Q

Factor that plays an essential role in producing an outcome

A

cause

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10
Q

alteration if factor A is directly related to change in factor B

A

direct causal

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11
Q

there is another factor that is associated with the chnage of outcome

A

indirect causal

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12
Q

presence of mechanism that leads from exposure to disease

A

cause

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13
Q

Identifiable relationship
between exposure and
disease

A

association

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14
Q

Process of Causal Inference:

A
  1. Determine the validity of the association
  2. Determine if observed association is causal
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15
Q

rule out chance, bias, confounding as explanation of the observed association

A

Determine the validity of the association

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16
Q

consider totality of evidence taken from a number of
sources

A

Determine if observed association is causal

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17
Q

2 types of validity:

A
  1. internal
  2. external
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18
Q
  • Validity within the study
  • Estimate of effect measure is accurate
  • Not due to systematic error
A

internal validity

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19
Q
  • Validity beyond the study
  • Estimate generalizable to bigger population
  • Not due to random error
A

external validity

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20
Q

Goal of Epidemiologic Studies

A

to estimate the value of the parameter with little error

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21
Q

Sources of errors:

A
  1. random errors
  2. systematic errors
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22
Q

because of sampling errors, chance

A

random errors

23
Q

because of biases and confounding

A

systematic errors

24
Q

difference between population value of parameter being investigated and the estimate value based on the different samples

A

random errors

25
distortion in the estimation of the magnitude of association between E and D (over or under estimation)
systematic errors
26
- deviation from the truth - due to bias
systematic errors
27
3 types of systematic errors due to biases:
1. selection 2. information 3. confounding
28
biases from non-representative sample
selection
29
biases from inaccurate info collected from sample
information
30
information bias types:
misclassification
31
2 kinds of misclassification:
non-differential differential
32
occurs when errors in similar proportion in grps being compared
non differential
33
- occurs when rate of errors differ in grps being compared - under and over estimation
differential
34
mixing the effect of exposure on the disease with that of 3rd factor
confounding
35
similar to non-causal
confounding
36
variable in confounding
confounder
37
* associate with exposure and outcome * risk factor in development of disease
confounder
38
should be ruled out when determiniing the validity if causal relationship
confounder
39
can lead to over and under estimation
confounding
40
sources of misclassification in information bias
1. instrument 2. subjects 3. observers
41
Methods to Control Confounding:
1. DESIGN STAGE 2. ANALYSIS STAGE
42
aim is random distribution of confounders between study groups
Randomization
43
restrict entry to study of individuals with confounding factor
Restriction
44
aim for equal distribution of confounders
Matching
45
confounders are distributed evenly within each stratum
Stratified analysis
46
a lot of ststistical tests applied to come up good analysis
multivariate analysis
47
Bradford Hill’s criteria for Causal Inference:
* Strength of association * Temporality * Consistency * Theoretical Plausibility * Coherence * Specificity in the Causes * Dose-Response Relationship * Experimental Evidence * Analogy
48
higher risk ratio, higher it will be causal
strength of association
49
* temporal relationship * exposure precedes disease
temporality
50
consistent finding across different designs/pop/investigators
consistency
51
not contradict the natural history of disease
theoretical plausibility
52
exposure leads to single effect
coherence
53
higher dose, higher outcome
dose exposure relationship