CBC

Question 1

WBC

Answer 1

(10^9/L)

Male and Female = 4.0 – 11.1

Question 2

RBC

Answer 2

(10^12/L)
Male = 4.7 – 6.0
Female = 4.1 – 5.6

Question 3

HGB

Answer 3

(g/dL)
Male = 14.3 – 18.1
Female = 12.1 – 16.3

Question 4

HCT

Answer 4

% = V of RBC in whole blood
= RBCxMCV = 3 x HGB
Male = 39.2 – 50.2
Female = 35.7 – 46.7

Question 5

MCV

Answer 5

(fL)
MCV =mean RBC size =HCT/RBC
Male and Female = 80.0 – 100.0

Question 6

MCH

Answer 6

(pg) quantity hgb in 1 RBC
Parallels MCV = HGB/RBC
Male and Female = 27.5 – 35.1

Question 7

MCHC

Answer 7

(g/dL) = avg [C] of hgb in 1 RBC
= HGB/HCT = MCH/MCV
Male and Female = 32.0 – 36.0

Question 8

RDW CV

Answer 8

Male and Female = 11.7 – 14.2

Question 9

RDW SD

Answer 9

Male and Female = 37.1 – 48.8

Question 10

PLT

Answer 10

(10^9/L)

Male and Female = 150 – 400

Question 11

MPV

Answer 11

(fL)

Male and Female = 9.6 – 12.8

Question 12

NE%

Answer 12

Male and Female = 39.7 – 72.1

Question 13

NE#

Answer 13

(10^9/L)

Male and Female = 1.8 – 6.6

Question 14

LY%

Answer 14

Male and Female = 20.0 – 50.0

Question 15

LY#

Answer 15

(10^9/L)

Male and Female = 1.0 – 4.8

Question 16

MO%

Answer 16

Male and Female = 2.0 – 11.0

Question 17

MO#

Answer 17

(10^9/L)

Male and Female = 0.2 – 0.9

Question 18

EO%

Answer 18

Male and Female = 0.0 – 6.0

Question 19

EO#

Answer 19

(10^9/L)

Male and Female = 0.0 – 0.4

Question 20

BA%

Answer 20

Male and Female = 0.0 – 2.0

Question 21

BA#

Answer 21

(10^9/L)

Male and Female = 0.0 – 0.2

Question 22

Male and Female have same values

Answer 22

WBC and WBC Differential, MCV, MCH, MCHC, RDW CV and SD, PLT, MPV

Question 23

RBC Morphology and Properties

Answer 23

Circular biconcave disc-shaped
Size: 6.7–7.7µm, mean 7.5µm
Lack of nuclei, Lack of Mitochondria
Anaerobic metabolism
Depends on GSH/phosphogluconate/NADPH for clearance of free radicals 
Eosinophilic cytoplasm
Central area of pallor, <1/3 of diameter

Question 24

Anemia

Answer 24

Decreased RBC, HGB, HCT
and Increased RDW
- due to blood loss, peripheral destruction, or ineffective erythropoiesis in the bone marrow

Question 25

Erythrocytosis/Polycythemia

Answer 25

Increased RBC, HGB, HCT | - due to reactive changes (smoking, renal cell carcinoma), or primary marrow neoplasm (polycythemia vera)

Question 26

HCT abnormal values

Answer 26

Decreased due to anemia or fluid overload | Increased due to erythrocytosis/polycythemia or dehydration

Question 27

MCV abnormal values

Answer 27

Low MCV: Microcytosis, iron deficiency anemia or thalassemia | High MCV: Macrocytosis, megaloblastic anemia

Question 28

MCH abnormal values

Answer 28

Low MCH: Hypochromatic, iron deficiency anemia | High MCH: Hyperchromatic, megaloblastic anemia

Question 29

MCHC abnormal values

Answer 29

Decreased in moderate to severe microcytic anemia Increased in hereditary spherocytosis, HbS, HbC Normal in macrocytic anemias

Question 30

RDW abnormal values

Answer 30

Increased in anemia and disease with RBC destruction (i.e. schistocytosis)

Question 31

Fe Deficiency Anemia

Answer 31

decreased RBC, HGB, HCT< MCV, MCH, MCHC | increased RDW

Question 32

Bite Cells

Answer 32

Bite-like detect due removal of Heinz body (Denatured/oxidized hemoglobin attached to the inner cell membrane) in spleen Associated with G6PD deficiency

Question 33

Target Cells

Answer 33

Central hemoglobin, target shape | Associated with Thalassemia, hemoglobin C, iron deficiency, liver disease

Question 34

Basophilic Stippling

Answer 34

Morphology: evenly dispersed fine blue granules Content: aggregated ribosomes (rRNA) Causes: Lead poisoning, porphyria, pyrimidine 5’ nucleotidase deficiency Hemoglobinopathies, thalassemia Myelodysplasia, sideroblastic anemia Infection

Question 35

Howell-Jolly bodies

Answer 35

``` Morphology: single, dense, blue dot Content: nuclear DNA remnant Causes: Post-splenectomy Functional asplenia Megaloblastic anemia Myelodysplasia ```