CBG Lecture 38: Extracellular Matrix Flashcards Preview

HELENP CBG: Cell Architecture, Communication and Regulation > CBG Lecture 38: Extracellular Matrix > Flashcards

Flashcards in CBG Lecture 38: Extracellular Matrix Deck (58)
Loading flashcards...
1

define ECM - extracellular matrix


complex network of polysacchs and proteins secreted by cells for strengthening tissues

2

what is a cell junction

directly links cells together in flexible tissues

3

what are the two types of animal tissue

connective
epithelial

4

what are the two main types of extracellular molecules that make up the matrix

GAGs - gycosaminoglycans
Fibrous proteins - collagen,lamins,elastin,fibronectin

5

what are GAGs

glycosaminoglycans
extracellular molecules that make up the matrix - usually found covalently linked to protein in the form of proteogylcans

6

what are proteoglans

GAGs - glycosaminoglycan polysaccharide chains usually found covalently linked to protein

7

name some fibrous proteins

collagen
laminin
elastin
fibronectin

8

what are epithelial sheets

sheet of cells covering surface of tissue which creates a barrier for multicellular orgs

9

what are the four main structures of cell

1.epithelial tissue
2.basal lamina
3.connective tissue
4.collagen fibres

10

what are the different epithelial tissues

simple
stratified
columnar
cuboidal
squamous

11

how are epithelial sheets polarised

have two faces: apical (exposed) and basal (rests on connective tissue)

12

what is basal end of epithelial sheet supported by

basal lamina - thin sheet of ECM

13

what is basal lamina composed of

type 4 collagen and laminin

14

what is laminin

links integrin - in the plasma membrane of epithelial cells - to CT (like fibronectin)

15

what links integrin to connective tissue

laminin

16

what is a cell-cell junction

connection between 2 cells or between cell and ECM
separates apical/basal surface and helps in cell-cell communication

17

give the names of cell-cell junctions

tight junction
adherens junction
desmosome
gap junction
hemidesmosome

18

what is the function of a tight junction

seals neighbouring cells together in an epithelial sheet to prevent leakage of molecules between them

19

what is an adherens junction

joins an actin bundle in one cell to a similar bundle in a neightbouring cells

20

what junction seals neighbouring cells together in an epithelial sheet to prevent leakage of molecules between them

tight junction

21

what junction connects actin bundle in one cell to a similar bundle in neighbouring cells

adherens junction

22

what is a desmosome

joins the intermediate filaments in one cell to those in a neighbour

23

what joins the intermediate filaments in one cell to the intermediate filaments of a neighbour

desmosome

24

what is a gap junction

forms channels that allow small water soluble molecules including ions to pass from cell to cells

25

what junction provides channels that allows small water soluble molecules including ions to pass from one cell to another

gap junction

26

what is a hemidesmosome

anchors intermediate filaments in a cell to the basal lamina

27

what anchors intermediate filaments in a cell to the basal lamina

hemidesomosome

28

what are CAMs

cell adhesion molecules

29

how to cells adhere to other cells

via transmembrane cadherin molecules that are connected to the cytoskeleton via linker proteins

30

what are the major families of cell adhesion molecules

1.cadherins
2.Ig-superfamily
3.integrins
4.selectins