CD Markers Flashcards Preview

Immunology > CD Markers > Flashcards

Flashcards in CD Markers Deck (16):
0

CD 2 ( LFA-2)

Cellular Expression- T cells, thymocytes, NK cells

Function- Adhesion molecule

1

CD3

Cellular Expression: T cells, thymocytes

Function: Signal transduction by the TCR

2

CD4

Cellular Expression: TH cells, thymocytes, monocytes and macrophages

Function: Coreceptor for MCH II interaction, receptor for HIV

3

CD8

Cellular Expression: CTLs, some thymocytes

Functions: Coreceptors for MHC Class I restricted T cells

4

CD14 (LPS receptor)

Cellular Expression: monocytes, macrophages, granulocytes

Function: Bind LPS

5

CD16 ( FCC Receptor)

Cellular Expression: NK cells, macrophages, Neutrophils

Function: Opsonization, ADCC

6

CD18

Cellular Expression: Leukocytes

Function: Cell adhesion molecule ( missing in leukocyte adhesion deficiency)

7

CD19

Cellular Expression: B cells

Function: Coreceptor for CD21 for B cell activation ( signal transduction)

8

CD20

Cellular Expression: Most or all B cells

Function: Unknown role in B cell activation

9

CD21( CR2, C3d receptor)

Cellular Expression: Mature B cells

Function: Receptor for complement fragment C3d, forms Coreceptor complex with CD19, EBV receptor

10

CD25

Cellular Expression: Activated TH cells and T reg

function: Alpha chain in IL2 receptor

11

CD28

Cellular Expression: T cells

Function: T cell receptor for costume layout molecule B 7

12

CD34

Cellular Expression: Precursors of hematopoietic cells, endothelial cells in HEV

Function: Cell-cell adhesion, bind to L-selection

13

CD40

Cellular Expression: B cell, macrophages, dendritic cells, endothelial cells

Function: binds CD40L, role in T-cell dependent B cell, macrophage, dendritic cell and endothelial cell activation

14

CD56

Cellular Expression: NK cells

Function: not know

15

CD152 (CTLA-4)

Cellular Expression: Activated T cell

Function: Negative regulation: Competes with CD28 for B7 binding