Cytokines Flashcards Preview

Immunology > Cytokines > Flashcards

Flashcards in Cytokines Deck (21):
0

Interleukin 1/ IL1

Secreted by: Monocytes, macrophages, B cells, dendritic cells, endothelial cells, other

Target/Act:
1. TH cells/ Costimulates activation
2.B Cells/ promotes maturation and clinal expression
3. NK Cells/ enhances activity
4. Endothelial Cells/increases expression of ICAMs
5. Macro and Neutrophils/ chemo tactically attracts
6. Hepatocytes/Induces synthesis of Acute Phase Proteins
7. hypothalamus/ induces fever

1

IL2

Secreted by: TH cells

Target/Activity
Antigen Primed TH and CTLs/ Induces proliferation and enhances activity

2

IL3

secreted by: TH cells, NK cells

Target/Activity
Hematopoietic cells/supports growth and differentiation

3

IL4

Secreted by TH2 cells

Target/ activity
1. Antigen primed B cells/ Costimulates activation

2. Activated B cells/ stimulates proliferation and differentiation, induces class switch to IgE

4

IL5

Secreted by: TH cells and mast cells

Target/ Activity
1. Activated B cells/ Stimulates proliferation and differentiation induces class switch to IgA

2. Bone Marrow cells/ induces eosinophil differentiation

5

IL 6

Secreted by: Monocytes, macrophages, TH2 cells, bone marrow strongly cells

Target/Activity
1. Proliferating B cells/promotes terminal differentiation into plasma cells
2. Plasma cells/ stimulates antibody secretion
3. Myeloid stem cell/ helps promote differentiation
4. Hepatocytes/ Induces synthesis of acute phase proteins

6

IL7

Secreted by: Bone marrow, thymocytes stromal cells

Target/Activity
1. Lymphoid Stem cells/ induces differentiation intro progenitor B and T cells

7

IL8

Secreted by: Macrophages, endothelial cells

Target/ Activity

Neutrophils/ chemokine, induces adherence to endothelium and extravasation into tissues

8

IL 10

Secreted by: TH2 cells, T reg cells

Target/ Activity

Macrophages/ suppresses cytokine production by TH1 cells

9

IL11

Secreted y : Bone marrow stroma

Target/ Activity:

Bone Marrow/ Increase platelet count

10

IL12

Secreted by: Macrophages, B cells

Target/ Activity;
1. Activated CD8 cells/ acts synergistically with IL2 to induce differentiation into CTLs
2. NK and LAK cells and activated TH1 cells/ Stimulates proliferation

11

IL 13

Secreted by TH2 cells

Target/ Activity:

B cells/ induces isotope switch to IgE

12

IL17

Secreted by TH17 cells

Target: Activity:

Fibroblasts, endothelial cells, macrophages/ Increases inflammation, and

attracts PMNS, induces IL6,1,
TGFbeta, TNFalpha,IL8

And role in autoimmune disease and allergy

13

Interferon Alpha type one

Secreted by Leukocytes

Target/ Activity:
Uninflected cells/Inhibits viral replication

14

Interferon Beta Type one

Secreted by Fibroblasts

Target/Activity:

Uninflected cells/ inhibits viral replication

15

IL gamma type two

Secreted by TH1, CTLs, NK cells

Target/ Qctivity:
1. Macrophages/ enhances activity
2. many cell types/ increases expression of MHC I and II
3. Proliferating B cells/ induces class switch to IgH2a , blocks IL4 induced class switch to IgE and IgG1
4. TH2 cells/ inhibits proliferation
5. Phagocytize cells/ mediates effects important in DTH, treatment for CGD

16

Transforming Growth Factor Beta

Secreted by platelets, macrophages, lymphocytes, mast cells

Target/ activity

1. Proliferating B cells/ induces class switch to IgA

17

TNF alpha

Secreted by macrophages, NK cells

Target/ Activity
1. Tumor cells/ cytotoxic effect
2. Inflammatory cells/ induces cytokine expression, causes cachexia of chronic inflammation

18

TNF beta

Secreted by: TH1 and C

Target/ Activity
1. Tumor cells/ cytotoxic effect
2. Macrophages and nuetrophils/ enhances phagocytic activity

19

Granulocyte Colony Stimulating Factor ( G-CSF)

Secreted by: Macrophages and TH cells

Target/ Activity
Bone marrow granulocyte precursor/ induce proliferation used clinically to counteract neutropenia following ablative chemotherapy

20

Granulocyte macrophage colony stimulating factor GM-CSF

Secreted by Macrophages and TH cells

Target/ Activity
Bone marrow granulocyte and macrophage precursor/ induces proliferation used clinically to counteract neutropenia following ablative therapy